Gene: PPM1B

5495
PP2C-beta|PP2C-beta-X|PP2CB|PP2CBETA|PPC2BETAX
protein phosphatase, Mg2+/Mn2+ dependent 1B
protein-coding
2p21
Ensembl:ENSG00000138032 MIM:603770 Vega:OTTHUMG00000128757 UniprotKB:O75688
NG_011678.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.579e-1 (AD)  5.520e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2053458chr2:44215940 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAD210.903
RNF1030.89
LMBRD10.876
UBL30.873
SEC620.872
SETD30.871
TMEM590.867
SGCB0.866
NAP1L40.866
ZMYND110.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.776
OR4F29-0.774
MTRNR2L3-0.292
C2orf83-0.292
SIX1-0.278
FER1L6-0.271
FCER2-0.261
TRIM10-0.261
CLEC12A-0.256
PZP-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PPM1B mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PPM1B mRNA"19114083
D000082AcetaminophenAcetaminophen results in increased expression of PPM1B mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PPM1B mRNA17562736
D000086AcetazolamideAcetazolamide results in increased expression of PPM1B mRNA19274763
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PPM1B mRNA22100608
D000638AmiodaroneAmiodarone results in increased expression of PPM1B mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PPM1B mRNA16483693
D001280AtrazineAtrazine results in decreased expression of PPM1B mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPM1B mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPM1B mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPM1B mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of PPM1B mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of PPM1B mRNA25047013
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPM1B mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PPM1B mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PPM1B promoter22457795
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPM1B mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA]"20230807
D002220CarbamazepineCarbamazepine affects the expression of PPM1B mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PPM1B mRNA23650126
D002994ClofibrateClofibrate results in decreased expression of PPM1B mRNA17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PPM1B mRNA17602206
D003024ClozapineClozapine results in decreased expression of PPM1B mRNA15860345
C018021cobaltous chloridecobaltous chloride results in increased expression of PPM1B mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of PPM1B mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of PPM1B mRNA19549813
D003907DexamethasoneDexamethasone results in increased expression of PPM1B mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPM1B mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PPM1B mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PPM1B mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PPM1B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PPM1B mRNA27392435
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of PPM1B mRNA21858171
D004041Dietary FatsDietary Fats results in increased expression of PPM1B mRNA19030233
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PPM1B mRNA17602206
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of PPM1B mRNA12655031
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PPM1B mRNA17555576
D005485FlutamideFlutamide results in increased expression of PPM1B mRNA24136188
D005897GlafenineGlafenine results in decreased expression of PPM1B mRNA24136188
D006220HaloperidolHaloperidol results in decreased expression of PPM1B mRNA15860345
D002112CalcifediolCalcifediol deficiency results in decreased expression of PPM1B mRNA17293106
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPM1B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPM1B mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PPM1B mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PPM1B mRNA27392435
C410337K 7174K 7174 results in increased expression of PPM1B mRNA24086573
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PPM1B mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PPM1B mRNA"26251327
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPM1B mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PPM1B mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA]"20230807
C008493methylselenic acidmethylselenic acid results in increased expression of PPM1B mRNA12517777
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PPM1B mRNA"25554681
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PPM1B mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA]"20230807
D010100OxygenOxygen deficiency results in increased expression of PPM1B mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of PPM1B mRNA]22629407
C006253pirinixic acidpirinixic acid results in decreased expression of PPM1B mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of PPM1B mRNA17426115
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of PPM1B mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of PPM1B mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of PPM1B mRNA21278054
D015474IsotretinoinIsotretinoin results in decreased expression of PPM1B mRNA20436886
D012645SelenomethionineSelenomethionine affects the expression of PPM1B mRNA17222674
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PPM1B mRNA23221170
C017947sodium arsenitesodium arsenite results in increased expression of PPM1B mRNA18812580
D012969Sodium FluorideSodium Fluoride results in increased expression of PPM1B protein28918527
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of PPM1B mRNA16214533
D013629TamoxifenTamoxifen affects the expression of PPM1B mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPM1B mRNA21215274
D014212TretinoinTretinoin results in decreased expression of PPM1B mRNA21934132
C012589trichostatin Atrichostatin A affects the expression of PPM1B mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PPM1B mRNA"26179874
D014520UrethaneUrethane results in increased expression of PPM1B mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PPM1B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of PPM1B gene29154799
D014635Valproic AcidValproic Acid affects the expression of PPM1B mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PPM1B gene25560391
D015032ZincZinc results in decreased expression of PPM1B mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of PPM1B mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004722protein serine/threonine phosphatase activity-IDA20801214  
GO:0005515protein binding-IPI16872604  17620599  18930133  25241761  
GO:0030145manganese ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IMP18930133  22750291  
GO:0006499N-terminal protein myristoylation-ISS-  
GO:0032688negative regulation of interferon-beta production-IMP22750291  
GO:0035970peptidyl-threonine dephosphorylation-IDA20801214  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IMP18930133  
GO:0050687negative regulation of defense response to virus-IMP22750291  
GO:1901223negative regulation of NIK/NF-kappaB signaling-IMP18930133  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-ISS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal