Gene info: ID 54962

Gene: TIPIN

GENE ID: 54962

Synonyms: -

Description: TIMELESS interacting protein

Gene type: protein-coding

Location: 15q22.31

dbXrefs: Ensembl:ENSG00000075131 MIM:610716 Vega:OTTHUMG00000133188 UniprotKB:Q9BVW5

RefSeq: NC_000015.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : 2.094e-2 (AD) 8.185e-1 (ND) (Frontal_Cortex)

Pascal p-value : 7.538e-2 (AD) 5.775e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZFAND6	0.664
NMD3	0.644
HAT1	0.638
CRLS1	0.635
ARFIP1	0.632
MRPL13	0.629
MARCH7	0.628
MLF1	0.627
SSR3	0.626
NCBP2	0.625

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.439
OR4F29	-0.394
C14orf180	-0.219
HMHB1	-0.218
NOTUM	-0.194
COL22A1	-0.188
DYNAP	-0.187
HCRTR1	-0.185
SERPINA11	-0.181
SSX5	-0.171

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of TIPIN mRNA"	26377693
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in decreased expression of TIPIN mRNA"	22101062
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TIPIN mRNA"	19167446
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in increased expression of TIPIN mRNA"	20406850
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIPIN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIPIN mRNA"	27188386
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of TIPIN mRNA"	19936915
D000082	Acetaminophen	Acetaminophen affects the expression of TIPIN mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of TIPIN mRNA	28959563
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in increased expression of TIPIN mRNA]	21233418
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TIPIN mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TIPIN mRNA	19770486
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of TIPIN mRNA	21298039
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of TIPIN mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TIPIN mRNA	20504355
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TIPIN mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TIPIN mRNA"	20382639
C006780	bisphenol A	bisphenol A affects the expression of TIPIN mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of TIPIN mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of TIPIN mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of TIPIN mRNA	26079696
C584509	C646 compound	C646 compound results in decreased expression of TIPIN mRNA	26191083
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TIPIN gene	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of TIPIN mRNA	28472532
D003078	Colchicine	Colchicine results in decreased expression of TIPIN mRNA	24211769
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of TIPIN mRNA	20971185
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TIPIN mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of TIPIN mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of TIPIN mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in increased expression of TIPIN mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of TIPIN mRNA	19770486
D000069439	Dasatinib	Dasatinib results in decreased expression of TIPIN mRNA	20579391
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TIPIN mRNA	17361019\|2126653
D002945	Cisplatin	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of TIPIN mRNA]	21858171
D002945	Cisplatin	Cisplatin results in decreased expression of TIPIN mRNA	24211769
C000944	dicrotophos	dicrotophos results in decreased expression of TIPIN mRNA	28302478
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TIPIN mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TIPIN mRNA]	17854601
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in increased expression of TIPIN mRNA]	21233418
D004967	Estrogens	Estrogens results in increased expression of TIPIN mRNA	21233418
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of TIPIN mRNA	28189721
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of TIPIN mRNA	24211769
D005047	Etoposide	Etoposide results in decreased expression of TIPIN mRNA	24211769
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TIPIN gene	20938992
D017313	Fenretinide	Fenretinide results in increased expression of TIPIN mRNA	28973697
D006918	Hydroxyurea	Hydroxyurea results in decreased expression of TIPIN mRNA	24211769
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TIPIN mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TIPIN mRNA	24796395
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TIPIN gene	20938992
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of TIPIN mRNA	20713471
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TIPIN mRNA	24211769
D016685	Mitomycin	Mitomycin results in decreased expression of TIPIN mRNA	24211769
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TIPIN mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TIPIN mRNA"	25554681
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of TIPIN mRNA	20971185
D010100	Oxygen	Oxygen deficiency results in decreased expression of TIPIN mRNA	26516004
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of TIPIN mRNA	23892564
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of TIPIN mRNA	24667235
D010634	Phenobarbital	Phenobarbital affects the expression of TIPIN mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in increased expression of TIPIN mRNA	18301758\|2381119
D010894	Piroxicam	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of TIPIN mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of TIPIN mRNA	21858171
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TIPIN mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of TIPIN mRNA	21632981
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of TIPIN mRNA	19167446
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of TIPIN mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in increased expression of TIPIN mRNA	28595984
C004648	testosterone enanthate	testosterone enanthate affects the expression of TIPIN mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TIPIN mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TIPIN mRNA	26290441
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TIPIN mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of TIPIN mRNA	23557971
D014212	Tretinoin	Tretinoin results in decreased expression of TIPIN mRNA	21934132
C012589	trichostatin A	trichostatin A results in increased expression of TIPIN mRNA	15901671
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of TIPIN mRNA	19042947
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of TIPIN mRNA	29024780
D014520	Urethane	Urethane results in decreased expression of TIPIN mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIPIN mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of TIPIN mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of TIPIN mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in increased expression of TIPIN mRNA	15901671
D000225	Adenine	Adenine results in decreased expression of TIPIN mRNA	24211769

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	17102137 24126761 24910198 25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000076	DNA replication checkpoint	-	IBA	21873635
GO:0000076	DNA replication checkpoint	-	IMP	17102137
GO:0008284	positive regulation of cell proliferation	-	IMP	17102137
GO:0009411	response to UV	-	IEA	-
GO:0031573	intra-S DNA damage checkpoint	-	IMP	17102137
GO:0033262	regulation of nuclear cell cycle DNA replication	-	TAS	17102137
GO:0043111	replication fork arrest	-	IBA	21873635
GO:0044770	cell cycle phase transition	-	IMP	17102137
GO:0048478	replication fork protection	-	IBA	21873635
GO:0051301	cell division	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	-	IDA	17102137
GO:0005634	nucleus	-	IDA	17102137
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IEA	-
GO:0031298	replication fork protection complex	-	IBA	21873635
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693538	Homology Directed Repair	TAS
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	TAS
R-HSA-5693607	Processing of DNA double-strand break ends	TAS
R-HSA-73894	DNA Repair	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28296937	Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)	Lin E	PLoS One