Gene: TTC12

54970
TPARM
tetratricopeptide repeat domain 12
protein-coding
11q23.2
Ensembl:ENSG00000149292 MIM:610732 Vega:OTTHUMG00000142832 UniprotKB:Q9H892
NC_000011.10
PubMed|SNP Mapped
2   ANCO-SNPs
OD|ND|AD
10   
3.937e-2 (AD)  8.504e-1 (ND)   (Frontal_Cortex)
2.197e-2 (AD)  9.224e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10891537chr11:113340648 (GRCh38.p7)T>A / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10502172chr11:113328424 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05127217chr11:113185802TTC12Promoter4.230e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DHTKD10.62
MCCC20.62
PLEKHG40.61
FAM227B0.597
LYPLAL10.594
ERMARD0.593
CPT20.593
ZMAT10.59
FPGS0.59
NEK80.589

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPPIN-0.3
MIP-0.297
RAX2-0.27
KLRG1-0.262
OR4F5-0.254
OR4F29-0.234
GAS2L3-0.219
CDX2-0.218
C9orf152-0.216
NPC1L1-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TTC12 mRNA23630614
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TTC12 mRNA24449571
D001151ArsenicArsenic affects the methylation of TTC12 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of TTC12 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of TTC12 mRNA"25351596
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTC12 mRNA21632981
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TTC12 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of TTC12 mRNA19619570
C006780bisphenol Abisphenol A affects the expression of TTC12 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of TTC12 mRNA29097150
C006780bisphenol Abisphenol A results in increased expression of TTC12 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TTC12 mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of TTC12 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of TTC12 mRNA26577399|2752363
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TTC12 mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TTC12 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TTC12 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TTC12 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of TTC12 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TTC12 mRNA20170705
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TTC12 mRNA20938992
C039281furanfuran results in increased expression of TTC12 mRNA25539665
D007213IndomethacinIndomethacin results in increased expression of TTC12 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TTC12 mRNA27392435
C544151jinfukangjinfukang results in increased expression of TTC12 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TTC12 mRNA24796395
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TTC12 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TTC12 mRNA28001369
C523799MRK 003TTC12 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TTC12 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TTC12 mRNA"25554681
D009532NickelNickel results in decreased expression of TTC12 mRNA24768652|2558310
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of TTC12 mRNA17616710
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TTC12 mRNA23608068
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TTC12 mRNA25351596
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TTC12 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TTC12 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTC12 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of TTC12 mRNA23411599
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TTC12 mRNA"26743178
D014638VanadatesVanadates results in decreased expression of TTC12 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TTC12 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IDA23300604  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18828801Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. (2008 Dec)Yang BZAlcohol Clin Exp Res
21663922Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium. (2011 Aug 15)McGuire VJ Neurol Sci
26410615An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans. (2015 Nov)Bidwell LCPharmacol Biochem Behav
25273375NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. (2015 Apr)Bidwell LCPsychopharmacology (Berl)
23303482ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. (2013 Mar)Nelson ECJAMA Psychiatry
19796663Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. (2010 Feb 1)Lucht MProg Neuropsychopharmacol Biol Psychiatry
17085484Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. (2006 Dec 15)Gelernter JHum Mol Genet
21168125TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. (2011 Apr 1)Ducci FBiol Psychiatry
17761687Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (2007 Dec 1)Yang BZHum Mol Genet
20133381Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans. (2010 Mar)David SPNicotine Tob Res