Gene: NMRK1

54981
C9orf95|NRK1|bA235O14.2
nicotinamide riboside kinase 1
protein-coding
9q21.13
Ensembl:ENSG00000106733 MIM:608704 Vega:OTTHUMG00000020034 UniprotKB:Q9NWW6
NC_000009.12
SNP Mapped
1   ANCO-SNPs
AD
0   
2.600e-1 (AD)  7.728e-1 (ND)   (Frontal_Cortex)
3.082e-1 (AD)  9.807e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2376397chr9:75075833 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLB0.835
CISD10.831
FAM136A0.826
OSTF10.821
MCTS10.817
YPEL50.816
FKBP30.814
PGRMC20.813
MKKS0.813
MRPL10.813

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.526
OR4F29-0.504
KLRB1-0.349
MTRNR2L10-0.341
MTRNR2L6-0.339
GPR171-0.313
P2RY14-0.31
FZD10-0.306
ZBTB20-0.303
C8orf74-0.29

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of NMRK1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of NMRK1 mRNA"21354444
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NMRK1 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NMRK1 mRNA21420995
D020106AcrylamideAcrylamide results in increased expression of NMRK1 mRNA28959563
D004958EstradiolEstradiol results in increased expression of NMRK1 mRNA26865669
C006780bisphenol Abisphenol A affects the expression of NMRK1 mRNA25181051
D001973BromodeoxyuridineBromodeoxyuridine results in increased expression of NMRK1 mRNA24910943
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of NMRK1 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NMRK1 mRNA27339419
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of NMRK1 mRNA26272509
D002996ClomipheneClomiphene results in decreased expression of NMRK1 mRNA26865669
D019327Copper SulfateCopper Sulfate results in decreased expression of NMRK1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of NMRK1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of NMRK1 mRNA20106945|2798913
C014347decitabinedecitabine affects the expression of NMRK1 mRNA23300844
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of NMRK1 mRNA28962523
D002945CisplatinCisplatin affects the expression of NMRK1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NMRK1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NMRK1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of NMRK1 mRNA28302478
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NMRK1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of NMRK1 mRNA19467301
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NMRK1 mRNA26865669
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of NMRK1 mRNA24834073
C118739entinostatentinostat results in increased expression of NMRK1 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
D004970EstroneEstrone results in increased expression of NMRK1 mRNA26865669
D008656MestranolMestranol results in increased expression of NMRK1 mRNA26865669
C024565ethylene dichlorideethylene dichloride results in decreased expression of NMRK1 mRNA28189721
C070081fulvestrantfulvestrant results in decreased expression of NMRK1 mRNA26865669
C039281furanfuran results in increased expression of NMRK1 mRNA25539665
D019833GenisteinGenistein results in increased expression of NMRK1 mRNA26865669
D006589HexestrolHexestrol results in increased expression of NMRK1 mRNA26865669
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NMRK1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NMRK1 mRNA21889194
C042720mercuric bromidemercuric bromide results in increased expression of NMRK1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NMRK1 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NMRK1 mRNA26011545
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NMRK1 mRNA26272509
C005556propionaldehydepropionaldehyde results in increased expression of NMRK1 mRNA26079696
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of NMRK1 mRNA26865669
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of NMRK1 mRNA25905778
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NMRK1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NMRK1 mRNA25351596
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of NMRK1 mRNA25905778
D013311StreptozocinStreptozocin results in increased expression of NMRK1 mRNA25905778
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NMRK1 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NMRK1 mRNA28922406
D019284ThapsigarginThapsigargin results in decreased expression of NMRK1 protein24648495
C012589trichostatin Atrichostatin A results in increased expression of NMRK1 mRNA24935251|2670570
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMRK1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NMRK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NMRK1 mRNA19101580|2317975

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004849uridine kinase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0050262ribosylnicotinamide kinase activity-EXP15137942  17914902  
GO:0061769ribosylnicotinate kinase activity-EXP15137942  17914902  
GO ID GO Term Qualifier Evidence PubMed
GO:0009435NAD biosynthetic process-IEA-  
GO:0016310phosphorylation-IEA-  
GO:0019674NAD metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00760Nicotinate and nicotinamide metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196807Nicotinate metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal