Gene: PINX1

54984
Gno1|LPTL|LPTS|Pxr1
PIN2 (TERF1) interacting telomerase inhibitor 1
protein-coding
8p23.1
Ensembl:ENSG00000254093 MIM:606505 Vega:OTTHUMG00000163808 UniprotKB:Q96BK5
NC_000008.11
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.168e-1 (AD)  7.204e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRPRB0.87
GRWD10.869
BYSL0.866
NOP160.864
GRPEL10.862
TMEM110.86
MED270.854
NTMT10.851
C14orf1190.848
NANS0.847

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.527
OR4F29-0.482
P2RY14-0.431
CYSLTR2-0.386
ASB4-0.38
PARD3B-0.375
COL4A3-0.341
DISC1-0.322
SLC2A4-0.322
VNN2-0.316

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006632arsenic trioxidearsenic trioxide results in decreased expression of PINX1 mRNA22944098
D001280AtrazineAtrazine results in decreased expression of PINX1 mRNA22378314
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PINX1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PINX1 mRNA27858113
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of PINX1 mRNA]15034205
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PINX1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PINX1 mRNA15034205
C006780bisphenol Abisphenol A affects the expression of PINX1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PINX1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of PINX1 mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PINX1 mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of PINX1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of PINX1 mRNA19320972
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PINX1 mRNA18355967
D003471CuprizoneCuprizone results in decreased expression of PINX1 mRNA26577399
C017160cypermethrincypermethrin results in increased expression of PINX1 mRNA21142847
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PINX1 mRNA17361019
C024629dimethyl phthalatedimethyl phthalate affects the expression of PINX1 mRNA26924002
D004147DioxinsDioxins affects the expression of PINX1 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PINX1 protein23301498
D005485FlutamideFlutamide results in increased expression of PINX1 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PINX1 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PINX1 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PINX1 mRNA23649840
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of PINX1 mRNA25270620
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PINX1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PINX1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PINX1 mRNA"25554681
D010416PentachlorophenolPentachlorophenol results in increased expression of PINX1 mRNA24642059
C046012pentanalpentanal results in increased expression of PINX1 mRNA26079696
D010795Phthalic AcidsPhthalic Acids results in decreased expression of PINX1 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of PINX1 mRNA23811191
C059514resveratrolresveratrol results in decreased expression of PINX1 protein25505154
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PINX1 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in decreased expression of PINX1 mRNA27862939
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PINX1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PINX1 mRNA15034205
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PINX1 mRNA25613284
D013893ThiramThiram results in increased expression of PINX1 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of PINX1 mRNA23557971
D014635Valproic AcidValproic Acid affects the expression of PINX1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of PINX1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PINX1 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions affects the expression of PINX1 mRNA23940539
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PINX1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11701125  15044100  15381700  17389648  18202258  19265708  
19393617  21044950  21119197  24415760  27214791  
GO:0010521telomerase inhibitor activity-IDA11701125  
GO:0010521telomerase inhibitor activity-IMP11701125  21119197  
GO:0010521telomerase inhibitor activity-NAS26194824  
GO:0010521telomerase inhibitor activity-TAS15381700  
GO:0044877protein-containing complex binding-IPI18202258  
GO:0070034telomerase RNA binding-IDA15381700  
GO ID GO Term Qualifier Evidence PubMed
GO:0007004telomere maintenance via telomerase-IDA11701125  
GO:0007080mitotic metaphase plate congression-IMP19393617  
GO:0008285negative regulation of cell proliferation-NAS11003615  
GO:0010972negative regulation of G2/M transition of mitotic cell cycle-IDA11701125  
GO:0031397negative regulation of protein ubiquitination-IMP24415760  
GO:0031647regulation of protein stability-IMP24415760  
GO:0032211negative regulation of telomere maintenance via telomerase-IDA11701125  
GO:0032211negative regulation of telomere maintenance via telomerase-IMP21119197  
GO:0051972regulation of telomerase activity-TAS15381700  
GO:0051974negative regulation of telomerase activity-IDA11701125  
GO:0051974negative regulation of telomerase activity-IMP11701125  21119197  
GO:0051974negative regulation of telomerase activity-NAS26194824  
GO:0070198protein localization to chromosome, telomeric region-IMP22749911  
GO:1902570protein localization to nucleolus-IDA24415760  
GO:1904357negative regulation of telomere maintenance via telomere lengthening-NAS26194824  
GO:1904744positive regulation of telomeric DNA binding-IDA19265708  24415760  
GO:1904751positive regulation of protein localization to nucleolus-IDA19265708  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosome-IDA19393617  
GO:0000776kinetochore-IDA19393617  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0000781chromosome, telomeric region-IDA11701125  
GO:0000784nuclear chromosome, telomeric region-IDA11701125  19265708  21119197  24415760  
GO:0005730nucleolus-IDA11701125  19265708  19393617  21119197  24415760  
GO:0005730nucleolus-NAS26194824  
GO:0005819spindle-IDA19393617  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25746325Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study. (2015 May 15)Li CGene
28372542The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway. (2017 Apr 4)Tian XPMol Cancer
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet