Gene: ULK4

54986
FAM7C1|REC01035
unc-51 like kinase 4
protein-coding
3p22.1
Ensembl:ENSG00000168038 MIM:617010 Vega:OTTHUMG00000156210 UniprotKB:Q96C45
NG_051047.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
5.468e-1 (AD)  8.903e-2 (ND)   (Frontal_Cortex)
7.909e-1 (AD)  5.272e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6809441chr3:41453114 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10446425chr3:41443340 (GRCh38.p7)C>Aalcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20724032chr3:41460736ULK44.900e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPICE10.599
NUP850.593
RPRD1B0.577
DDX19A0.574
GON4L0.573
SART30.567
IFT810.567
ITFG20.566
MDC10.565
CYB5D10.564

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.284
CTNNA3-0.283
LPAR1-0.268
OR4F29-0.267
C5orf64-0.264
BCAS1-0.255
PAIP2B-0.255
SLCO1A2-0.25
MOBP-0.248
SPRR2E-0.24

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ULK4 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ULK4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ULK4 mRNA"27188386
C016601afimoxifeneULK4 results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ULK4 gene27153756
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ULK4 mRNA"19446018
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ULK4 mRNA21871943
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of ULK4 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of ULK4 mRNA25181051
D002737ChloropreneChloroprene results in increased expression of ULK4 mRNA23125180
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ULK4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ULK4 mRNA27392435
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ULK4 mRNA23649840
D017313FenretinideFenretinide results in increased expression of ULK4 mRNA28973697
C051890irinotecanirinotecan analog results in decreased expression of ULK4 mRNA18927307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ULK4 mRNA27392435
D007854LeadLead results in increased expression of ULK4 mRNA19921347
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ULK4 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ULK4 mRNA"25554681
D009532NickelNickel results in decreased expression of ULK4 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of ULK4 mRNA19167457
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ULK4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ULK4 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of ULK4 mRNA20813756
D011374ProgesteroneProgesterone results in increased expression of ULK4 mRNA20864642
D011374ProgesteroneProgesterone results in increased expression of ULK4 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of ULK4 mRNA24780913
D015474IsotretinoinIsotretinoin results in decreased expression of ULK4 mRNA20436886
C017947sodium arsenitesodium arsenite results in decreased expression of ULK4 mRNA21457566|2271453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ULK4 mRNA24680724
D014520UrethaneUrethane results in increased expression of ULK4 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ULK4 mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of ULK4 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IMP24284070  
GO:0006468protein phosphorylation-IEA-  
GO:0010975regulation of neuron projection development-IMP24284070  
GO:0043408regulation of MAPK cascade-IMP24284070  
GO:0046328regulation of JNK cascade-IMP24284070  
GO:0090036regulation of protein kinase C signaling-IMP24284070  
GO:1900744regulation of p38MAPK cascade-IMP24284070  
GO:2001222regulation of neuron migration-IMP24284070  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25519342Bivariate genetic association analysis of systolic and diastolic blood pressure by copula models. (2014)Konigorski SBMC Proc