Gene: MARC2

54996
MOSC2
mitochondrial amidoxime reducing component 2
protein-coding
1q41
Ensembl:ENSG00000117791 MIM:614127 Vega:OTTHUMG00000037354 UniprotKB:Q969Z3
NC_000001.11
SNP Mapped
4   ANCO-SNPs
AD
0   
2.000e-1 (AD)  2.199e-1 (ND)   (Frontal_Cortex)
5.296e-1 (AD)  2.820e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11118597chr1:220763226 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3795536chr1:220762635 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10779415chr1:220762466 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6659246chr1:220757885 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPH0.873
SPARCL10.84
CYB5R10.838
BBS20.835
COX150.827
FAM213A0.818
MCCC20.818
ALDH5A10.817
IVD0.816
ABI10.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.583
OR4F29-0.539
TRPV5-0.296
MTRNR2L6-0.289
KLF17-0.279
SH2D1A-0.278
OR6C74-0.277
CTNNA3-0.276
KRT72-0.276
CETP-0.273

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MARC2 mRNA"23146750
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MARC2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MARC2 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of MARC2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MARC2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MARC2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MARC2 mRNA16483693
C053561benzamidoxime[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC2 protein] results in increased reduction of benzamidoxime22924387
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of MARC2 mRNA27685785
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MARC2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MARC2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MARC2 mRNA28628672
D002065BuspironeBuspirone results in increased expression of MARC2 mRNA24136188
D002104CadmiumCadmium results in increased expression of MARC2 mRNA23256528
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MARC2 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride affects the methylation of MARC2 promoter22457795
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of MARC2 promoter22457795
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of MARC2 promoter22457795
D002994ClofibrateClofibrate results in decreased expression of MARC2 mRNA17585979
D009243NAD[MARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MARC2 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of MARC2 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MARC2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MARC2 mRNA28628672
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of MARC2 mRNA27638505
C118739entinostatentinostat results in increased expression of MARC2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC2 mRNA"27188386
D015025ZearalenoneZearalenone results in increased expression of MARC2 protein25058043
D005419FlavonoidsFlavonoids results in decreased expression of MARC2 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of MARC2 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of MARC2 mRNA24136188
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of MARC2 mRNA25270620
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of MARC2 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MARC2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MARC2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MARC2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MARC2 mRNA28628672
C410337K 7174K 7174 results in increased expression of MARC2 mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of MARC2 mRNA16807920
D008694MethamphetamineMARC2 gene SNP affects the susceptibility to Methamphetamine18316681
C010737N(4)-hydroxycytidine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC2 protein] results in increased reduction of N(4)-hydroxycytidine22924387
C021202N(4)-hydroxycytosine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC2 protein] results in increased reduction of N(4)-hydroxycytosine22924387
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MARC2 mRNA"25554681
D009532NickelNickel results in decreased expression of MARC2 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of MARC2 mRNA22714537
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of MARC2 mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MARC2 mRNA20971185
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MARC2 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MARC2 mRNA]"21673326
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARC2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of MARC2 mRNA26272509
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MARC2 mRNA23146750
D010634PhenobarbitalPhenobarbital results in decreased expression of MARC2 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of MARC2 mRNA20813756
D011441PropylthiouracilPropylthiouracil results in decreased expression of MARC2 mRNA24780913
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of MARC2 mRNA25626140
C010313pseudocumenepseudocumene results in decreased expression of MARC2 protein17337753
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MARC2 mRNA21427059
C059873sulfamethoxazole hydroxylamine[MARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MARC2 mRNA20106945|2163298
D019284ThapsigarginThapsigargin results in increased expression of MARC2 mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of MARC2 mRNA27188386
D014241TrichloroethyleneTrichloroethylene results in increased expression of MARC2 mRNA19448997
D014415TunicamycinTunicamycin results in increased expression of MARC2 mRNA22378314
C022884undecaneundecane results in decreased expression of MARC2 protein17337753
D014635Valproic AcidValproic Acid affects the expression of MARC2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MARC2 mRNA19101580
D014635Valproic AcidValproic Acid affects the expression of MARC2 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of MARC2 mRNA20546886|2142705
D015032ZincZinc deficiency results in increased expression of MARC2 mRNA12672911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008940nitrate reductase activity-IDA20861021  
GO:0030151molybdenum ion binding-IDA20861021  
GO:0030170pyridoxal phosphate binding-IEA-  
GO:0043546molybdopterin cofactor binding-IDA20861021  
GO ID GO Term Qualifier Evidence PubMed
GO:0042126nitrate metabolic process-IDA20861021  
GO:0051410detoxification of nitrogen compound-NAS20861021  
GO:0055114oxidation-reduction process-IDA20861021  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-ISS-  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005777peroxisome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal