Gene: AURKAIP1

54998
AIP|AKIP|MRP-S38
aurora kinase A interacting protein 1
protein-coding
1p36.33
Ensembl:ENSG00000175756 MIM:609183 Vega:OTTHUMG00000001413 UniprotKB:Q9NWT8
NC_000001.11
PubMed
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.567e-1 (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01508988chr1:1310123AURKAIP1Gene body1.941e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDUFB70.967
CCDC1240.966
NDUFS80.964
GADD45GIP10.957
NDUFA130.956
RPS19BP10.955
ANAPC110.952
GPX40.952
NDUFB100.95
PLEKHJ10.949

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.804
OR4F29-0.777
PZP-0.278
HMCN1-0.264
ZC3H11B-0.263
MTRNR2L6-0.262
MTRNR2L9-0.262
COL14A1-0.258
FER1L6-0.257
KCNJ15-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AURKAIP1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of AURKAIP1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of AURKAIP1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AURKAIP1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AURKAIP1 mRNA19770486
D001280AtrazineAtrazine results in decreased expression of AURKAIP1 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of AURKAIP1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of AURKAIP1 mRNA25181051
C100187chloropicrinchloropicrin results in increased expression of AURKAIP1 mRNA26352163
D002994ClofibrateClofibrate affects the expression of AURKAIP1 mRNA17585979
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of AURKAIP1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AURKAIP1 mRNA]17585979
D016572CyclosporineCyclosporine results in increased expression of AURKAIP1 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AURKAIP1 mRNA21266533
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of AURKAIP1 mRNA24834073
D018120FinasterideFinasteride results in increased expression of AURKAIP1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of AURKAIP1 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of AURKAIP1 mRNA22061828
D005897GlafenineGlafenine results in increased expression of AURKAIP1 mRNA24136188
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of AURKAIP1 mRNA17183730
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AURKAIP1 mRNA23086925
D008748MethylcholanthreneMethylcholanthrene results in increased expression of AURKAIP1 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AURKAIP1 mRNA26011545
D012969Sodium FluorideSodium Fluoride results in decreased expression of AURKAIP1 mRNA27862939
D013467SulindacSulindac results in decreased expression of AURKAIP1 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AURKAIP1 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AURKAIP1 mRNA19770486
D014212TretinoinTretinoin results in decreased expression of AURKAIP1 mRNA17218384
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of AURKAIP1 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of AURKAIP1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of AURKAIP1 gene29154799
C025643vinclozolinvinclozolin results in increased expression of AURKAIP1 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12244051  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006397mRNA processing-IBA21873635  
GO:0045839negative regulation of mitotic nuclear division-NAS12244051  
GO:0045862positive regulation of proteolysis-IDA12244051  
GO:0070125mitochondrial translational elongation-TAS-  
GO:0070126mitochondrial translational termination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12244051  
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005840ribosome-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5368286Mitochondrial translation initiationIEA
R-HSA-5368287Mitochondrial translationTAS
R-HSA-5368287Mitochondrial translationIEA
R-HSA-5389840Mitochondrial translation elongationIEA
R-HSA-5389840Mitochondrial translation elongationTAS
R-HSA-5419276Mitochondrial translation terminationTAS
R-HSA-72766TranslationTAS
R-HSA-72766TranslationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal