Gene: MCUB

55013
CCDC109B
mitochondrial calcium uniporter dominant negative beta subunit
protein-coding
4q25
Ensembl:ENSG00000005059 Vega:OTTHUMG00000161103 UniprotKB:Q9NWR8
NC_000004.12
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.027e-1 (AD)  3.636e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9996730chr4:109648939 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs12640500chr4:109588030 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MCUB mRNA"27291303
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCUB mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of MCUB mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of MCUB mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MCUB mRNA24449571
C547126AZM551248AZM551248 results in increased expression of MCUB mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MCUB mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MCUB mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MCUB mRNA22228805
D004958EstradiolEstradiol results in increased expression of MCUB mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of MCUB mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of MCUB mRNA25181051
C059041calyculin Acalyculin A results in increased expression of MCUB mRNA25270620
D002220CarbamazepineCarbamazepine affects the expression of MCUB mRNA25979313
D002737ChloropreneChloroprene results in decreased expression of MCUB mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MCUB mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of MCUB mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCUB mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of MCUB mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of MCUB mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of MCUB mRNA20106945
D016572CyclosporineCyclosporine results in increased methylation of MCUB promoter27989131
D016572CyclosporineCyclosporine results in decreased expression of MCUB mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of MCUB mRNA23640034
D002945CisplatinCisplatin results in increased expression of MCUB mRNA27594783
C118739entinostatentinostat results in decreased expression of MCUB mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MCUB mRNA20938992
D017313FenretinideFenretinide results in decreased expression of MCUB mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MCUB mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MCUB mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MCUB mRNA28001369
C523799MRK 003MCUB results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MCUB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MCUB mRNA"25554681
D009532NickelNickel results in increased expression of MCUB mRNA24768652|2558310
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of MCUB mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MCUB mRNA26272509
D011374ProgesteroneProgesterone results in decreased expression of MCUB mRNA22238285
D011794QuercetinQuercetin results in decreased expression of MCUB mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in increased expression of MCUB mRNA23221170
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MCUB mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MCUB mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MCUB mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MCUB mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of MCUB mRNA22378314
D014212TretinoinTretinoin results in decreased expression of MCUB mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCUB mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of MCUB mRNA24935251|2627250
D014635Valproic AcidValproic Acid affects the expression of MCUB mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MCUB mRNA23179753|2718838
C111237vorinostatvorinostat results in increased expression of MCUB mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005216ion channel activityNOTISS-  
GO:0005262calcium channel activity-IBA21873635  
GO:0015292uniporter activity-IBA21873635  
GO:0019855calcium channel inhibitor activity-IBA21873635  
GO:0019855calcium channel inhibitor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006851mitochondrial calcium ion transmembrane transport-ISS-  
GO:0006851mitochondrial calcium ion transmembrane transport-TAS-  
GO:0036444calcium import into the mitochondrion-IBA21873635  
GO:0051560mitochondrial calcium ion homeostasis-IBA21873635  
GO:0051560mitochondrial calcium ion homeostasis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-ISS-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0031224intrinsic component of membrane-ISS-  
GO:0031305integral component of mitochondrial inner membrane-IBA21873635  
GO:0031305integral component of mitochondrial inner membrane-IDA24231807  
GO:0034704calcium channel complex-ISS-  
GO:1990246uniplex complex-IBA21873635  
GO:1990246uniplex complex-IDA24231807  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-8949215Mitochondrial calcium ion transportTAS
R-HSA-8949664Processing of SMDT1TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal