Gene: PID1

55022
HMFN2073|NYGGF4|P-CLI1|PCLI1
phosphotyrosine interaction domain containing 1
protein-coding
2q36.3
Ensembl:ENSG00000153823 MIM:612930 Vega:OTTHUMG00000133191 UniprotKB:Q7Z2X4
NC_000002.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.013e-1 (AD)  4.289e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1419951chr2:229134886 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OXCT10.895
PRPS10.891
PLEKHB20.89
PNMA20.887
DENR0.886
MAP20.886
C19orf120.885
WDR820.885
NECAP10.884
ATP6V1A0.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.601
OR4F29-0.547
CSAG1-0.371
NFE2-0.362
RAI14-0.355
S100A12-0.351
VNN3-0.349
MAGEA12-0.348
IL18RAP-0.344
TFPI2-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of PID1 mRNA"26377693
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PID1 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PID1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PID1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PID1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PID1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PID1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PID1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PID1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PID1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PID1 mRNA19770486
D000447AldehydesAldehydes results in increased expression of PID1 mRNA25014914
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PID1 mRNA"24160326|2575705
D001280AtrazineAtrazine results in decreased expression of PID1 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of PID1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PID1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PID1 mRNA19770486
D004958EstradiolEstradiol affects the expression of PID1 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PID1 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of PID1 mRNA17404688
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PID1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PID1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PID1 mRNA20147733
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PID1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of PID1 mRNA26079696
D016572CyclosporineCyclosporine results in decreased expression of PID1 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PID1 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of PID122733784
D003976DiazinonDiazinon results in increased methylation of PID1 gene22964155
D002945CisplatinCisplatin results in increased expression of PID1 mRNA27392435
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of PID1 mRNA21852083
D004147DioxinsDioxins affects the expression of PID1 mRNA20463971
C118739entinostatentinostat results in increased expression of PID1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PID1 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PID1 mRNA22079256
C039281furanfuran results in decreased expression of PID1 mRNA25539665
C546771gardiquimodgardiquimod results in decreased expression of PID1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of PID1 mRNA]28003376
C412815GW 4064GW 4064 results in decreased expression of PID1 mRNA26655953
D017313FenretinideFenretinide results in decreased expression of PID1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PID1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PID1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PID1 mRNA28628672
D007840LatexLatex analog results in decreased expression of PID1 mRNA24768652
D064704LevofloxacinLevofloxacin results in increased expression of PID1 mRNA24136188
C005219methyl cellosolvemethyl cellosolve results in increased expression of PID1 mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PID1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PID1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PID1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PID1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PID1 mRNA"25620056
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PID1 mRNA"27188386
C046012pentanalpentanal results in increased expression of PID1 mRNA26079696
D010795Phthalic AcidsPhthalic Acids results in increased expression of PID1 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PID1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PID1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PID1 mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PID1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of PID1 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of PID1 mRNA17404688
C005556propionaldehydepropionaldehyde results in increased expression of PID1 mRNA26079696
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of PID1 mRNA]28003376
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of PID1 mRNA21852083
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of PID1 mRNA"24160326
D012834SilverSilver results in decreased expression of PID1 mRNA27131904
D018038Sodium SeleniteSodium Selenite results in increased expression of PID1 mRNA24383545
D053260SootSoot results in decreased expression of PID1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PID1 mRNA11489354
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PID1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PID1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of PID1 mRNA23409001
C012589trichostatin Atrichostatin A results in increased expression of PID1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PID1 mRNA"24407104
D014635Valproic AcidValproic Acid affects the expression of PID1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PID1 mRNA24383497|2493525
D014638VanadatesVanadates results in increased expression of PID1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PID1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0001933negative regulation of protein phosphorylation-IDA19079291  
GO:0006112energy reserve metabolic process-IC20165904  
GO:0010628positive regulation of gene expression-IMP20165904  
GO:0010635regulation of mitochondrial fusion-IC20165904  
GO:0044320cellular response to leptin stimulus-IEA-  
GO:0045444fat cell differentiationNOTIDA16815647  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP20165904  
GO:0046627negative regulation of insulin receptor signaling pathway-IDA19079291  
GO:0051881regulation of mitochondrial membrane potential-ISS-  
GO:0051881regulation of mitochondrial membrane potential-TAS20165904  
GO:0070346positive regulation of fat cell proliferation-IDA16815647  
GO:0070584mitochondrion morphogenesis-IMP20165904  
GO:0071345cellular response to cytokine stimulus-ISS-  
GO:0071354cellular response to interleukin-6-ISS-  
GO:0071356cellular response to tumor necrosis factor-ISS-  
GO:0071356cellular response to tumor necrosis factor-NAS20140872  
GO:0071398cellular response to fatty acid-ISS-  
GO:1903077negative regulation of protein localization to plasma membrane-IDA19079291  
GO:2000377regulation of reactive oxygen species metabolic process-ISS-  
GO:2000379positive regulation of reactive oxygen species metabolic process-IMP20165904  
GO:2001170negative regulation of ATP biosynthetic process-IMP20165904  
GO:2001171positive regulation of ATP biosynthetic process-ISS-  
GO:2001274negative regulation of glucose import in response to insulin stimulus-IDA19079291  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA16815647  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27154971The Effect of Different Case Definitions of Current Smoking on the Discovery of Smoking-Related Blood Gene Expression Signatures in Chronic Obstructive Pulmonary Disease. (2016 Sep)Obeidat MNicotine Tob Res