Gene: PHIP

55023
BRWD2|DCAF14|WDR11|ndrp
pleckstrin homology domain interacting protein
protein-coding
6q14.1
Ensembl:ENSG00000146247 MIM:612870 Vega:OTTHUMG00000015071 UniprotKB:Q8WWQ0
NG_051932.1
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.866e-1 (AD)  8.139e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP3K20.886
ZNF6440.877
BROX0.876
UFL10.876
ARID20.876
PKN20.867
LRRC580.861
LMAN10.857
SENP70.854
MIER30.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.548
OR4F29-0.52
KCNG2-0.222
GGN-0.211
NPW-0.205
TNFRSF18-0.205
CMA1-0.191
SHISA8-0.191
TGM3-0.185
SULT2B1-0.181

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHIP mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHIP mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHIP mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHIP mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHIP mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHIP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHIP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHIP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHIP mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PHIP mRNA25064622
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PHIP gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PHIP mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of PHIP mRNA25064622
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHIP mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHIP mRNA21839799
C044887beta-methylcholinebeta-methylcholine affects the expression of PHIP mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of PHIP mRNA25181051
D002737ChloropreneChloroprene results in increased expression of PHIP mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of PHIP mRNA25064622
D004390ChlorpyrifosChlorpyrifos results in decreased expression of PHIP mRNA20350560
D003010ClorgylineClorgyline results in increased expression of PHIP mRNA19691856
D019327Copper SulfateCopper Sulfate results in increased expression of PHIP mRNA19549813
D016572CyclosporineCyclosporine affects the expression of PHIP mRNA25064622
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PHIP mRNA21266533
D002945CisplatinPHIP protein affects the susceptibility to Cisplatin16217747
D004041Dietary FatsDietary Fats results in increased expression of PHIP mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of PHIP mRNA]19030233
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PHIP mRNA22079256
D000431EthanolEthanol results in decreased expression of PHIP mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PHIP mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PHIP mRNA29097150
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of PHIP mRNA]15016801
D005557FormaldehydeFormaldehyde results in increased expression of PHIP mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of PHIP mRNA22634610
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PHIP mRNA25613284
C544151jinfukangjinfukang results in decreased expression of PHIP mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PHIP mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PHIP mRNA23649840
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PHIP mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHIP mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of PHIP mRNA26272509
D010269ParaquatParaquat affects the expression of PHIP mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHIP mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of PHIP mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PHIP mRNA27153767
D010634PhenobarbitalPhenobarbital results in decreased expression of PHIP mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of PHIP mRNA20813756
D010894PiroxicamPiroxicam results in increased expression of PHIP mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of PHIP mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PHIP mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PHIP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PHIP mRNA22079256
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of PHIP mRNA]19030233
D012715Sesame OilSesame Oil results in increased expression of PHIP mRNA29191790
C017947sodium arsenitesodium arsenite affects the methylation of PHIP gene28589171
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PHIP mRNA21641980
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PHIP mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PHIP mRNA18691609|1977048
D013752TetracyclineTetracycline affects the expression of PHIP mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PHIP mRNA25613284
D013792ThalidomideThalidomide results in increased expression of PHIP mRNA28892372
D019284ThapsigarginThapsigargin results in increased expression of PHIP protein24648495
D013853ThioacetamideThioacetamide affects the expression of PHIP mRNA25064622
C009495titanium dioxidetitanium dioxide results in increased expression of PHIP mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PHIP mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PHIP mRNA15894607
C012589trichostatin Atrichostatin A affects the expression of PHIP mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of PHIP mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of PHIP mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PHIP mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHIP mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PHIP mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of PHIP mRNA20546886
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PHIP gene25560391
C025643vinclozolinvinclozolin affects the expression of PHIP mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005158insulin receptor binding-NAS11018022  
GO:0005515protein binding-IPI11018022  
GO:0070577lysine-acetylated histone binding-IDA22464331  
GO ID GO Term Qualifier Evidence PubMed
GO:0001932regulation of protein phosphorylation-ISS-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0007010cytoskeleton organization-IBA21873635  
GO:0007010cytoskeleton organization-IMP21834987  
GO:0008284positive regulation of cell proliferation-ISS-  
GO:0008286insulin receptor signaling pathway-NAS11018022  
GO:0008360regulation of cell shape-IBA21873635  
GO:0022604regulation of cell morphogenesis-IMP21834987  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0043568positive regulation of insulin-like growth factor receptor signaling pathway-ISS-  
GO:0045840positive regulation of mitotic nuclear division-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17636024  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IDA17636024  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21432116Human Glutathione S-transferase A1 polymorphism and susceptibility to oral squamous cell carcinoma in Japanese. (2005 Nov)Komiya YEnviron Health Prev Med
15797627Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population. (2005 Apr 18)Komiya YCancer Lett
10517990Effect of cigarette smoke on the mutagenic activation of environmental carcinogens by rodent liver. (1999 Jul 16)Koide AMutat Res
28629854Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate. (2017 Oct)Sayyed KToxicol In Vitro
26574651Measurement of the Heterocyclic Amines 2-Amino-9H-pyrido[2,3-b]indole and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Urine: Effects of Cigarette Smoking. (2015 Dec 21)Konorev DChem Res Toxicol
15073045Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans. (2004 Sep)Walters DGCarcinogenesis
14504191Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer. (2003 Sep)Zhu JCancer Epidemiol Biomarkers Prev
21081473Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. (2011 Feb)Wang HCarcinogenesis
14601045Genetic polymorphisms and modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human lymphocytes. (2003 Dec 20)Magagnotti CInt J Cancer
11532863Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man. (2001 Sep)Murray SCarcinogenesis