Gene: TMEM255A

55026
FAM70A
transmembrane protein 255A
protein-coding
Xq24
Ensembl:ENSG00000125355 Vega:OTTHUMG00000022298 UniprotKB:Q5JRV8
NC_000023.11
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12857770chrX:120259745 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STK32A0.785
LHFPL30.765
DIRAS30.749
C1orf870.737
ARHGAP60.735
BLM0.713
PBX30.711
HAS20.698
CRNDE0.693
IGF2BP20.691

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOHLH1-0.5
YBX2-0.467
EMX1-0.452
NEUROD2-0.432
TRIM54-0.429
TNNT2-0.425
SLC6A7-0.421
SLC30A3-0.419
BAIAP2L2-0.413
SCRT2-0.41

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMEM255A mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of TMEM255A mRNA"19095052
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMEM255A mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMEM255A mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMEM255A mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMEM255A mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM255A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM255A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM255A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM255A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM255A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM255A mRNA"27188386
D000447AldehydesAldehydes results in increased expression of TMEM255A mRNA25014914
C015001arsenitearsenite results in increased methylation of TMEM255A promoter23974009
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TMEM255A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of TMEM255A mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TMEM255A promoter]19654925
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of TMEM255A mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TMEM255A mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of TMEM255A mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of TMEM255A mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of TMEM255A mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TMEM255A mRNA21266533
D017313FenretinideFenretinide results in increased expression of TMEM255A mRNA28973697
C008261lead acetatelead acetate results in increased expression of TMEM255A mRNA22839698
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TMEM255A mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM255A mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TMEM255A mRNA26011545
D009532NickelNickel results in decreased expression of TMEM255A mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of TMEM255A mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of TMEM255A mRNA22714537
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TMEM255A mRNA27935865
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMEM255A mRNA"25510870
C046012pentanalpentanal results in increased expression of TMEM255A mRNA26079696
C005556propionaldehydepropionaldehyde results in increased expression of TMEM255A mRNA26079696
D011794QuercetinQuercetin results in decreased expression of TMEM255A mRNA21632981
C017947sodium arsenitesodium arsenite results in decreased expression of TMEM255A mRNA22714537
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of TMEM255A mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TMEM255A promoter]19654925
C009495titanium dioxidetitanium dioxide results in increased expression of TMEM255A mRNA23557971
D014212TretinoinTretinoin results in decreased expression of TMEM255A mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM255A mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TMEM255A mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of TMEM255A mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TMEM255A mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TMEM255A mRNA29024780
D014520UrethaneUrethane results in decreased expression of TMEM255A mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM255A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TMEM255A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TMEM255A mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TMEM255A gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TMEM255A mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal