Gene: ATG16L1

55054
APG16L|ATG16A|ATG16L|IBD10|WDR30
autophagy related 16 like 1
protein-coding
2q37.1
Ensembl:ENSG00000085978 MIM:610767 UniprotKB:Q676U5
NG_023038.1
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.552e-1 (AD)  1.093e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZFYVE270.956
UQCC10.953
UBE2O0.95
PPME10.948
PRDM20.947
TRIM30.944
POLR3A0.943
ARHGEF70.943
SEC61A20.942
HERC10.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.503
ASB4-0.473
MYL3-0.472
YES1-0.472
COPZ2-0.462
MBNL3-0.454
OR4F29-0.454
PHEX-0.441
MYOM1-0.438
PARD3B-0.437

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ATG16L1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ATG16L1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ATG16L1 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ATG16L1 mRNA]"19467301
D000082AcetaminophenAcetaminophen results in increased expression of ATG16L1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ATG16L1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ATG16L1 gene27153756
C044887beta-methylcholinebeta-methylcholine affects the expression of ATG16L1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of ATG16L1 mRNA29027980
C006780bisphenol Abisphenol A affects the expression of ATG16L1 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of ATG16L1 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of ATG16L1 mRNA18804290
D019256Cadmium ChlorideATG16L1 protein affects the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]29218509
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATG16L1 mRNA18804290
D019256Cadmium ChlorideATG16L1 protein affects the susceptibility to Cadmium Chloride29218509
D019256Cadmium Chloride[ATG16L1 protein affects the susceptibility to Cadmium Chloride] which results in increased cleavage of CASP3 protein29218509
D002211CapsaicinCapsaicin results in decreased expression of ATG16L1 mRNA20349343
D019327Copper SulfateCopper Sulfate results in increased expression of ATG16L1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ATG16L1 mRNA25562108
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ATG16L1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of ATG16L1 mRNA19467301
C496966Eudragit RSPOEudragit RSPO results in increased expression of ATG16L1 mRNA22119964
C069837fullerene C60fullerene C60 results in increased expression of ATG16L1 mRNA19167457
C037032galangin[ATG16L1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein25268046
C037032galangingalangin results in increased expression of ATG16L1 mRNA25268046
C037032galangingalangin results in increased expression of ATG16L1 protein25268046
C037032galanginLY2109761 inhibits the reaction [galangin results in increased expression of ATG16L1 protein]25268046
C037032galanginSMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG16L1 protein]25268046
D007213IndomethacinIndomethacin results in increased expression of ATG16L1 mRNA28201806
C530108LY2109761LY2109761 inhibits the reaction [galangin results in increased expression of ATG16L1 protein]25268046
D008558MelphalanMelphalan results in increased expression of ATG16L1 mRNA22363485
D008727MethotrexateMethotrexate results in increased expression of ATG16L1 mRNA21678067
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ATG16L1 mRNA"26251327
D008777MethyltestosteroneMethyltestosterone results in decreased expression of ATG16L1 mRNA29191790
C028007nickel monoxidenickel monoxide results in increased expression of ATG16L1 mRNA19167457
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of ATG16L1 mRNA24583197
D012402RotenoneRotenone results in decreased expression of ATG16L1 mRNA23186747
D012715Sesame OilSesame Oil results in increased expression of ATG16L1 mRNA29191790
D012999SomanSoman results in increased expression of ATG16L1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATG16L1 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of ATG16L1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ATG16L1 mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of ATG16L1 gene27618143
D014635Valproic AcidValproic Acid results in increased expression of ATG16L1 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ATG16L1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17353931  20562859  23202584  23262492  23376921  23392225  
26347139  
GO:0019787ubiquitin-like protein transferase activity-TAS-  
GO:0042802identical protein binding-IPI20562859  23392225  
GO:0051020GTPase binding-IPI25891078  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0000045autophagosome assembly-NAS15620219  
GO:0015031protein transport-IEA-  
GO:0016236macroautophagy-TAS-  
GO:0034497protein localization to phagophore assembly site-IEA-  
GO:0039689negative stranded viral RNA replication-IBA21873635  
GO:0051260protein homooligomerization-NAS15620219  
GO:0061739protein lipidation involved in autophagosome assembly-IEA-  
GO:0098792xenophagy-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000421autophagosome membrane-IBA21873635  
GO:0005776autophagosome-ISS15620219  
GO:0005829cytosol-TAS-  
GO:0005930axoneme-ISS-  
GO:0034045phagophore assembly site membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1632852MacroautophagyTAS
R-HSA-1632852MacroautophagyIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29434451Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. (2018 Feb 7)Gathungu GWorld J Gastroenterol
28826742A comprehensive review and update on Crohn's disease. (2018 Feb)Gajendran MDis Mon
22719818Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition. (2012)Li EPLoS One
18671817ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: further support for significant disease heterogeneity. (2008 Oct)Fowler EVAm J Gastroenterol
24012056Association of Egr-1 and autophagy-related gene polymorphism in men with chronic obstructive pulmonary disease. (2015 Aug)Chen CZJ Formos Med Assoc
21206965IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes. (2011 Mar)Lauriola MInt J Mol Med
28631723Pharmacogenetic biomarkers of response in Crohn's disease. (2018 Jan)Linares-Pineda TMPharmacogenomics J
24989722Smoking behaviour modifies IL23r-associated disease risk in patients with Crohn's disease. (2015 Feb)Doecke JDJ Gastroenterol Hepatol