Gene: PPP1R3A

5506
GM|PP1G|PPP1R3
protein phosphatase 1 regulatory subunit 3A
protein-coding
7q31.1
Ensembl:ENSG00000154415 MIM:600917 Vega:OTTHUMG00000156944 UniprotKB:Q16821
NG_012116.1
PubMed
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.375e-1 (AD)  2.556e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CEACAM30.757
MROH50.741
FER1L60.738
OR52E40.738
RNF170.733
DPPA40.728
AADACL20.713
WDR720.712
OR6Q10.711
GSDMA0.71

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.438
C16orf95-0.394
FAM43B-0.394
TM7SF2-0.393
UCN-0.391
CYP46A1-0.391
MAGIX-0.389
C19orf44-0.38
TMEM240-0.376
ABCB8-0.373

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R3A mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PPP1R3A mRNA"27291303
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R3A mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R3A mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R3A mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R3A mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of PPP1R3A mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of PPP1R3A mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of PPP1R3A mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PPP1R3A gene27153756
C006780bisphenol Abisphenol A results in decreased expression of PPP1R3A mRNA17706920
C006780bisphenol Abisphenol A results in increased expression of PPP1R3A mRNA25594700
C006780bisphenol ALHB protein affects the reaction [bisphenol A results in decreased expression of PPP1R3A mRNA]17706920
C006780bisphenol Abisphenol A results in decreased expression of PPP1R3A mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of PPP1R3A mRNA18579281
D003630DaunorubicinDaunorubicin results in decreased expression of PPP1R3A mRNA26537877|2894005
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PPP1R3A mRNA28085963
D004317DoxorubicinDoxorubicin results in decreased expression of PPP1R3A mRNA26537877|2894005
D008942MitoxantroneMitoxantrone results in decreased expression of PPP1R3A mRNA26537877|2894005
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PPP1R3A mRNA27935865
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PPP1R3A mRNA"25510870
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PPP1R3A mRNA27935865
D011192Potassium DichromatePotassium Dichromate results in increased expression of PPP1R3A mRNA23608068
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3A mRNA"18579281
C004648testosterone enanthatetestosterone enanthate affects the expression of PPP1R3A mRNA17440010
D014212TretinoinTretinoin results in increased expression of PPP1R3A mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of PPP1R3A mRNA28973375
D014635Valproic AcidValproic Acid results in decreased methylation of PPP1R3A gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PPP1R3A gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of PPP1R3A mRNA25423262
C025643vinclozolinvinclozolin results in increased expression of PPP1R3A mRNA23160963

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005977glycogen metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04910Insulin signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26043790Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)Guo MLAutophagy