Gene: ZCWPW1

55063
ZCW1
zinc finger CW-type and PWWP domain containing 1
protein-coding
7q22.1
Ensembl:ENSG00000078487 Vega:OTTHUMG00000159537 UniprotKB:Q9H0M4
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
7.694e-1 (AD)  7.922e-1 (ND)   (Frontal_Cortex)
7.605e-1 (AD)  3.438e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DBNDD20.795
HIRIP30.773
TPRN0.751
SIRT20.75
MRPL480.749
CCDC1590.748
MAP6D10.747
QDPR0.747
TARSL20.745
COL9A20.744

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.42
OR4F5-0.4
NHS-0.302
FER1L6-0.291
ELF5-0.282
DNAH11-0.282
MS4A3-0.277
MAP3K15-0.276
SPRY1-0.269
SUCNR1-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of ZCWPW1 mRNA"21346803
D001280AtrazineAtrazine results in decreased expression of ZCWPW1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZCWPW1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZCWPW1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZCWPW1 mRNA"26238291
C006780bisphenol Abisphenol A results in decreased methylation of ZCWPW1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of ZCWPW1 mRNA20739668
C006780bisphenol Abisphenol A results in increased expression of ZCWPW1 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of ZCWPW1 mRNA19549813
C492448ICG 001ICG 001 results in increased expression of ZCWPW1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZCWPW1 mRNA25613284
C544151jinfukangjinfukang results in increased expression of ZCWPW1 mRNA27392435
C028007nickel monoxidenickel monoxide results in increased expression of ZCWPW1 mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ZCWPW1 mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ZCWPW1 mRNA27935865
D011441PropylthiouracilPropylthiouracil results in increased expression of ZCWPW1 mRNA24780913
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of ZCWPW1 mRNA19244175
D012643SeleniumSelenium results in increased expression of ZCWPW1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ZCWPW1 mRNA25351596
D012834SilverSilver results in increased expression of ZCWPW1 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZCWPW1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZCWPW1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZCWPW1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of ZCWPW1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of ZCWPW1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ZCWPW1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ZCWPW1 gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of ZCWPW1 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of ZCWPW1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget