Gene: ENOX1

55068
CNOX|PIG38|bA64J21.1|cCNOX
ecto-NOX disulfide-thiol exchanger 1
protein-coding
13q14.11
Ensembl:ENSG00000120658 MIM:610914 Vega:OTTHUMG00000016818 UniprotKB:Q8TC92
NG_052843.1
PubMed|SNP Mapped
8   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.516e-1 (AD)  2.038e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3884613chr13:43511809 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1323161chr13:43426495 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12857536chr13:43309468 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs9533443chr13:43293604 (GRCh38.p7)G>A / G>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs12874803chr13:43285188 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10507519chr13:43240987 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs930577chr13:43232753 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2289774chr13:43224212 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10201400chr13:44359601ENOX1Promoter2.046e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF80.889
CCDC1270.887
PJA10.886
AFTPH0.884
TSPAN50.881
C16orf700.881
UBE2Z0.881
RMND5A0.879
ANKH0.878
PPID0.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.483
IL18RAP-0.459
OR4F29-0.448
SLC2A4-0.435
KLRB1-0.416
KLRF1-0.416
FZD10-0.411
RNF135-0.403
TFPI2-0.398
CD248-0.396

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOX1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ENOX1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ENOX1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ENOX1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ENOX1 gene27153756
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ENOX1 mRNA"19150397
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ENOX1 mRNA20147733
D002220CarbamazepineCarbamazepine affects the expression of ENOX1 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ENOX1 gene20938992
C014347decitabinedecitabine results in decreased expression of ENOX1 mRNA19363521
C014347decitabineTP53 protein affects the reaction [decitabine results in decreased expression of ENOX1 mRNA]19363521
D003703DemecolcineDemecolcine results in increased expression of ENOX1 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of ENOX1 mRNA25047013
C540355fenamidonefenamidone results in decreased expression of ENOX1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ENOX1 gene20938992
D008558MelphalanMelphalan results in decreased expression of ENOX1 mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ENOX1 gene20938992
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ENOX1 mRNA22401849
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOX1 mRNA"27188386
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOX1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ENOX1 mRNA26272509
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of ENOX1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of ENOX1 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ENOX1 mRNA23608068
C045362prochlorazprochloraz results in increased expression of ENOX1 mRNA21470553
C005556propionaldehydepropionaldehyde results in increased expression of ENOX1 mRNA26079696
C502851quinocetonequinocetone results in increased expression of ENOX1 mRNA27046791
C009495titanium dioxidetitanium dioxide results in increased expression of ENOX1 mRNA23131501
C012589trichostatin Atrichostatin A results in increased expression of ENOX1 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOX1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ENOX1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ENOX1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ENOX1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ENOX1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ENOX1 gene25560391
D014750VincristineVincristine results in increased expression of ENOX1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0005515protein binding-IPI16189514  25416956  
GO:0016491oxidoreductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007624ultradian rhythm-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27164557Genetic Relationship between Schizophrenia and Nicotine Dependence. (2016 May 10)Chen JSci Rep