Gene: OXR1

55074
Nbla00307|TLDC3
oxidation resistance 1
protein-coding
8q23.1
Ensembl:ENSG00000164830 MIM:605609 Vega:OTTHUMG00000167682 UniprotKB:Q8N573
NC_000008.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.864e-1 (AD)  4.027e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6996005chr8:106520699 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18444875chr8:107460168OXR12.200e-9Maternal smoking in pregnancy27040690
cg18444875chr8:107460168OXR13.710e-9Maternal smoking in pregnancy27040690
cg18444875chr8:107460168OXR14.230e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AKT30.966
SLC4A100.966
SGTB0.965
ATP6V1A0.965
SYNJ10.965
TRIM370.964
PIK3CB0.961
STAU20.961
DPP100.961
MYCBP20.96

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.528
HEY2-0.506
RAB13-0.498
RNF135-0.495
MYL3-0.482
CHST14-0.476
STON2-0.474
ROM1-0.467
SYDE1-0.466
LRAT-0.459

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of OXR1 mRNA"19162173
C0326681-nitropyrene1-nitropyrene results in increased expression of OXR1 mRNA19041380
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of OXR1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of OXR1 mRNA22230336|2570463
D000082AcetaminophenAcetaminophen affects the expression of OXR1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of OXR1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of OXR1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of OXR1 mRNA24449571
C000228aristolochic acid Iaristolochic acid I results in increased expression of OXR1 mRNA17483316
D001280AtrazineAtrazine results in decreased expression of OXR1 mRNA22378314
D001374AzacitidineAzacitidine results in increased expression of OXR1 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of OXR1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OXR1 mRNA"20018196
C006780bisphenol Abisphenol A results in increased expression of OXR1 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of OXR1 mRNA26191083
C034939cadmium sulfidecadmium sulfide results in increased expression of OXR1 mRNA27866839
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of OXR1 mRNA24763279
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of OXR1 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of OXR1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of OXR1 mRNA19549813
C089595cylindrospermopsincylindrospermopsin results in increased expression of OXR1 mRNA24921660
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of OXR1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of OXR1 mRNA28302478
D004317DoxorubicinDoxorubicin results in increased expression of OXR1 mRNA28940058
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of OXR1 mRNA17555576
D005944GlucosamineGlucosamine results in decreased expression of OXR1 mRNA17178593
D005947GlucoseGlucose results in decreased expression of OXR1 mRNA17178593
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of OXR1 mRNA24763279
C492448ICG 001ICG 001 results in increased expression of OXR1 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of OXR1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of OXR1 mRNA27392435
D007854LeadLead affects the splicing of OXR1 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of OXR1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of OXR1 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of OXR1 mRNA29191790
D008825MiconazoleMiconazole results in decreased expression of OXR1 mRNA22262564
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of OXR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of OXR1 mRNA"25554681
D009532NickelNickel results in decreased expression of OXR1 mRNA25583101
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of OXR1 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of OXR1 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of OXR1 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of OXR1 mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of OXR1 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of OXR1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of OXR1 mRNA21632981
D012715Sesame OilSesame Oil results in increased expression of OXR1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of OXR1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of OXR1 mRNA19073995
D012969Sodium FluorideSodium Fluoride results in decreased expression of OXR1 protein28918527
D013629TamoxifenTamoxifen affects the expression of OXR1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of OXR1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OXR1 mRNA21215274
D014212TretinoinTretinoin results in increased expression of OXR1 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of OXR1 mRNA19448997
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of OXR1 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of OXR1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of OXR1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of OXR1 mRNA23179753|2915479
D014638VanadatesVanadates results in decreased expression of OXR1 mRNA22714537
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of OXR1 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of OXR1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of OXR1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of OXR1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0016491oxidoreductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006979response to oxidative stress-NAS11114193  
GO:0007628adult walking behavior-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0051402neuron apoptotic process-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0071447cellular response to hydroperoxide-IEA-  
GO:1902083negative regulation of peptidyl-cysteine S-nitrosylation-IEA-  
GO:1903204negative regulation of oxidative stress-induced neuron death-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IEA-  
GO:0005739mitochondrion-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23797033Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis. (2013 Dec)D'Amico EFree Radic Biol Med