Gene: TMEM45A

55076
DERP7|DNAPTP4
transmembrane protein 45A
protein-coding
3q12.2
Ensembl:ENSG00000181458 MIM:616928 Vega:OTTHUMG00000150327 UniprotKB:Q9NWC5
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.490e-1 (AD)  5.726e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4928112chr3:100544715 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UPK1B0.627
ZNF3000.625
ARHGAP60.624
TMEM255A0.615
KCNJ20.612
PAWR0.609
PBX30.596
C6orf1320.591
ARHGEF350.584
KRT230.581

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG13-0.368
HAPLN4-0.354
SLC6A7-0.349
TESPA1-0.345
TMEM221-0.343
SPDEF-0.343
EMX1-0.338
CBLN2-0.338
YBX2-0.337
SLC30A3-0.337

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA]"24403227
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TMEM45A mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM45A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM45A mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TMEM45A mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of TMEM45A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TMEM45A gene27153756
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of TMEM45A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMEM45A mRNA21632981
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TMEM45A mRNA19619570
D004958EstradiolEstradiol results in increased expression of TMEM45A mRNA19619570
D004958EstradiolEstradiol results in increased expression of TMEM45A mRNA19484750
C044887beta-methylcholinebeta-methylcholine affects the expression of TMEM45A mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of TMEM45A mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TMEM45A mRNA25596134
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TMEM45A mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMEM45A mRNA20938992
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of TMEM45A mRNA18078969
C018021cobaltous chloridecobaltous chloride results in increased expression of TMEM45A mRNA22202117
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of TMEM45A mRNA]22202117
D019327Copper SulfateCopper Sulfate results in decreased expression of TMEM45A mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TMEM45A mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of TMEM45A mRNA20106945
D003561CytarabineCytarabine results in decreased expression of TMEM45A mRNA21198554
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TMEM45A mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TMEM45A mRNA25596134|2739243
D004237DiuronDiuron results in decreased expression of TMEM45A mRNA25152437
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMEM45A mRNA20938992
C039281furanfuran results in increased expression of TMEM45A mRNA27387713
C568713GSK1210151AGSK1210151A inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA]27292261
C554645GSK525762AGSK525762A inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA]27292261
D017313FenretinideFenretinide results in decreased expression of TMEM45A mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TMEM45A mRNA20044591
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TMEM45A mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TMEM45A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA]27292261
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TMEM45A mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TMEM45A mRNA27292261
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TMEM45A mRNA26644586
C410337K 7174K 7174 results in decreased expression of TMEM45A mRNA24086573
D008154LucanthoneLucanthone results in increased expression of TMEM45A mRNA21148553
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMEM45A mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TMEM45A mRNA23179753|2718838
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TMEM45A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TMEM45A mRNA"25554681
D009532NickelNickel results in increased expression of TMEM45A mRNA18922574
C022838nickel chloridenickel chloride results in increased expression of TMEM45A mRNA21455298
C029938nickel sulfatenickel sulfate results in increased expression of TMEM45A mRNA22714537
C558013NSC 689534NSC 689534 results in increased expression of TMEM45A mRNA20971185
D019319Okadaic AcidOkadaic Acid results in increased expression of TMEM45A mRNA25270620
D010100Oxygen"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA]"24403227
D010100OxygenGSK1210151A inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA]27292261
D010100OxygenGSK525762A inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA]27292261
D010100Oxygen(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA]27292261
D010100OxygenOxygen deficiency results in increased expression of TMEM45A mRNA20042640|2423605
D010100OxygenOxygen deficiency results in increased expression of TMEM45A mRNA20880076
D010634PhenobarbitalPhenobarbital affects the expression of TMEM45A mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM45A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TMEM45A mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TMEM45A mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of TMEM45A mRNA23012394|2301818
D011374ProgesteroneProgesterone results in increased expression of TMEM45A mRNA21540246
D011794QuercetinQuercetin results in decreased expression of TMEM45A mRNA21632981
D011794QuercetinQuercetin results in increased expression of TMEM45A mRNA19729006
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TMEM45A mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMEM45A mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM45A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TMEM45A mRNA15667827|1993321
D014212TretinoinTretinoin results in decreased expression of TMEM45A mRNA21934132
D014212TretinoinTretinoin results in decreased expression of TMEM45A mRNA20488242
C011559tributyltintributyltin results in decreased expression of TMEM45A mRNA27614199
C012589trichostatin Atrichostatin A results in increased expression of TMEM45A mRNA24935251
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TMEM45A mRNA29024780
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of TMEM45A mRNA18078969
D014520UrethaneUrethane results in decreased expression of TMEM45A mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TMEM45A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TMEM45A mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in decreased methylation of TMEM45A gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TMEM45A mRNA24896083
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of TMEM45A mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal