Gene: MED9

55090
MED25
mediator complex subunit 9
protein-coding
17p11.2
Ensembl:ENSG00000141026 MIM:609878 Vega:OTTHUMG00000059293 UniprotKB:Q9NWA0
NC_000017.11
SNP Mapped
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.219e-1 (AD)  8.544e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERAL10.926
SIRT30.925
NFS10.921
UBE2I0.921
DKK30.918
UNC1190.916
CHST10.914
ZSCAN180.912
TMEM90.912
SMYD50.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.689
OR4F29-0.638
TFPI2-0.42
MTRNR2L6-0.414
KLRB1-0.411
MTRNR2L9-0.402
KLRF1-0.393
C2orf83-0.383
GZMK-0.38
MTRNR2L10-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of MED9 mRNA17562736
D001151ArsenicArsenic affects the methylation of MED9 gene25304211
C006780bisphenol Abisphenol A results in increased expression of MED9 mRNA25047013
C006780bisphenol Abisphenol A results in decreased expression of MED9 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of MED9 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MED9 mRNA20106945
D003561CytarabineCytarabine results in decreased expression of MED9 mRNA19194470
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MED9 mRNA21266533
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of MED9 mRNA27638505
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of MED9 mRNA22079256
C492448ICG 001ICG 001 results in decreased expression of MED9 mRNA26191083
C410337K 7174K 7174 results in increased expression of MED9 mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MED9 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MED9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MED9 mRNA"25554681
C025256nonylphenolnonylphenol results in decreased expression of MED9 mRNA22982499
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MED9 mRNA18593933
C006253pirinixic acidpirinixic acid results in increased expression of MED9 mRNA17426115|1830175
D010936Plant ExtractsPlant Extracts results in decreased expression of MED9 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of MED9 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MED9 mRNA22079256
D012834SilverSilver results in decreased expression of MED9 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MED9 mRNA21354282
D013853ThioacetamideThioacetamide results in increased expression of MED9 mRNA23411599
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MED9 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of MED9 mRNA20044591
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MED9 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14638676  15175163  24882805  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016592mediator complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal