Gene: SAMD4B

55095
SMGB|Smaug2
sterile alpha motif domain containing 4B
protein-coding
19q13.2
Ensembl:ENSG00000179134 Vega:OTTHUMG00000182967 UniprotKB:Q5PRF9
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.238e-1 (AD)  5.486e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs30454chr19:39353536 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SKI0.876
ATN10.867
ZCCHC140.853
PRRC2A0.851
KHSRP0.85
TFE30.843
TRAF70.835
PPARD0.832
WIZ0.829
ACO20.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.724
OR4F29-0.675
OR6C74-0.285
CETP-0.264
NANOGNB-0.245
XCL2-0.234
CLEC6A-0.229
KLRC2-0.227
C17orf112-0.215
HMHB1-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of SAMD4B mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of SAMD4B mRNA26690555|2906747
C006780bisphenol Abisphenol A results in increased expression of SAMD4B mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of SAMD4B mRNA26191083
D002994ClofibrateClofibrate results in decreased expression of SAMD4B mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of SAMD4B mRNA19320972
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SAMD4B mRNA23640034
C000944dicrotophosdicrotophos results in increased expression of SAMD4B mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SAMD4B protein23301498
D005485FlutamideFlutamide results in increased expression of SAMD4B mRNA20566332
C069837fullerene C60fullerene C60 results in decreased expression of SAMD4B mRNA19167457
C492448ICG 001ICG 001 results in decreased expression of SAMD4B mRNA26191083
C028007nickel monoxidenickel monoxide results in decreased expression of SAMD4B mRNA19167457
C017557nickel subsulfidenickel subsulfide results in increased expression of SAMD4B mRNA21086188
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SAMD4B protein23718831
D012999SomanSoman results in increased expression of SAMD4B mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SAMD4B mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SAMD4B mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of SAMD4B mRNA23411599
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of SAMD4B mRNA18422935

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0003729mRNA binding-IBA21873635  
GO:0005515protein binding-IPI15161933  17353931  24255178  
GO:0030371translation repressor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0017148negative regulation of translation-IBA21873635  
GO:0043488regulation of mRNA stability-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal