Gene: AVP

551
ADH|ARVP|AVP-NPII|AVRP|VP
arginine vasopressin
protein-coding
20p13
Ensembl:ENSG00000101200 MIM:192340 Vega:OTTHUMG00000031733 UniprotKB:P01185
NG_008663.1
PubMed
CD|OD|ND|AD
32   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.422e-1 (AD)  6.561e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24257309chr20:3065423AVP1.900e-10Smoking27651444
cg23169111chr20:3065582AVP4.800e-9Smoking27651444

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OXT0.952
OTP0.914
FOXB10.91
HCRT0.907
HMX20.905
LHX50.903
SIM10.9
PMCH0.893
C22orf420.892
NTS0.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGLL-0.354
LZTS1-0.332
CYTH3-0.313
RGS5-0.313
ANKS1A-0.304
MGAT5B-0.296
MLLT6-0.293
SHANK3-0.293
KCNH3-0.291
ZBTB40-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

    There is no CTD record for this GENE !

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
hsa04962Vasopressin-regulated water reabsorption
Reactome ID Reactome Term Evidence
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388479Vasopressin-like receptorsTAS
R-HSA-400253Circadian ClockIEA
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5619099Defective AVP causes neurohypophyseal diabetes insipidus (NDI)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-879518Transport of organic anionsTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-9036092Defective AVP causes neurohypophyseal diabetes insipidus (NDI)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21752550Sex differences in effects of cigarette smoking and 24-hr abstinence on plasma arginine vasopressin. (2011 Nov)Guaderrama MMAddict Behav
15721055Male patients with paranoid schizophrenia have greater ACTH and cortisol secretion in response to metoclopramide-induced AVP release. (2005 Jun)Walsh PPsychoneuroendocrinology
25446223Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats. (2015 Feb)Zhou YPhysiol Behav
24845178Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. (2014 Jul)Levran OPsychoneuroendocrinology
3600293Naloxone decreases the inhibiting effect of ethanol on the release of arginine-vasopressin induced by cigarette smoking in man. (1987 Aug)Chiodera PMetabolism
15043349Nicotine replacement therapy-associated syndrome of inappropriate antidiuretic hormone. (2004 Mar)Finch CKSouth Med J
15334375Difference between diabetic and nondiabetic smokers in the pituitary response to physical exercise. (2004 Sep)Coiro VMetabolism
19596360Arginine vasopressin gene expression changes within the nucleus accumbens during environment elicited cocaine-conditioned response in rats. (2010 Jan)Rodriguez-Borrero ENeuropharmacology
6548876Skin blood flow reduction induced by cigarette smoking: role of vasopressin. (1984 Dec)Waeber BAm J Physiol
630725The effect of pain on plasma arginine vasopressin concentrations in man. (1978 Feb)Kendler KSClin Endocrinol (Oxf)
6479376[A sensitive and specific radioimmunoassay for arginine vasopressin and its validation]. (1984 Mar 20)Oki YNihon Naibunpi Gakkai Zasshi
2434764Clinical studies with a vascular vasopressin antagonist. (1986)Waeber BJ Cardiovasc Pharmacol
29325449Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood. (2018 Jan 12)Marzi SJAm J Psychiatry
7586596The effects of alcoholism on the hypothalamic-pituitary-adrenal axis: interaction with endogenous opioid peptides. (1995 Sep)Inder WJClin Endocrinol (Oxf)
26969417Single-Dose Interaction Study of the Arginine Vasopressin Type 1B Receptor Antagonist ABT-436 and Alcohol in Moderate Alcohol Drinkers. (2016 Apr)Katz DAAlcohol Clin Exp Res
25402718Angiopoietins 1 and 2 in sputum supernatant of optimally treated asthmatics: the effect of smoking. (2015 Jan)Petta VEur J Clin Invest
15203290Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers. (2004 Jul-Aug)Zimmermann UJ Psychiatr Res
1325853The role of vasopressin in the nicotine-induced stimulation of ACTH and cortisol in men. (1992 Mar-Apr)Stalke JClin Investig
17507236Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting. (2007 Jul)Novella SEur J Cardiothorac Surg
23347332A novel echocardiographic method for the detection of subclinical atherosclerosis in newly diagnosed, untreated type 2 diabetes. (2013 Jul)Simsek HEchocardiography
7106059The levels of vasopressin in cerebrospinal fluid of patients with alcoholism. (1982 Feb)Noto TEndocrinol Jpn
3168397Response of plasma arginine vasopressin to nicotine in normal man. (1988 Oct)Goldsmith SRClin Pharmacol Ther
3214943Endogenous opioids inhibit oxytocin release during nicotine-stimulated secretion of vasopressin in man. (1988 May)Seckl JRClin Endocrinol (Oxf)
1031496Radioimmunoassay of vasopressin in unextracted plasma. (1976 Dec)Fyhrquist FScand J Clin Lab Invest
9071954Vasopressin and oxytocin levels during normal pregnancy: effects of chronic dietary sodium restriction. (1997 Mar)van der Post JAJ Endocrinol
24766650Drug addiction and stress-response genetic variability: association study in African Americans. (2014 Jul)Levran OAnn Hum Genet
27070740The effect of chronic morphine or methadone exposure and withdrawal on clock gene expression in the rat suprachiasmatic nucleus and AA-NAT activity in the pineal gland. (2016 Jul 18)Pacesova DPhysiol Res
29406581Corticotropin-releasing factor receptor 2-deficiency eliminates social behaviour deficits and vulnerability induced by cocaine. (2018 May)Morisot NBr J Pharmacol
9622448More vasopressin mRNA in the paraventricular hypothalamic nucleus of alcohol-preferring rats and high alcohol-drinking rats selectively bred for high alcohol preference. (1998 May)Hwang BHAlcohol Clin Exp Res
21677651Persistent increase in hypothalamic arginine vasopressin gene expression during protracted withdrawal from chronic escalating-dose cocaine in rodents. (2011 Sep)Zhou YNeuropsychopharmacology
3697900Correlation of cigarette-induced increase in serum nicotine levels with arginine vasopressin concentrations in the syndrome of self-induced water intoxication and psychosis (SIWIP). (1986 Mar)Vieweg WVCan J Psychiatry
3834412The role of arginine vasopressin in alcohol dependence and withdrawal. (1985 Nov-Dec)Ruwe WDPeptides