Gene: ANO1

55107
DOG1|ORAOV2|TAOS2|TMEM16A
anoctamin 1
protein-coding
11q13.3
Ensembl:ENSG00000131620 MIM:610108 Vega:OTTHUMG00000167204 UniprotKB:Q5XXA6
NC_000011.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
5.436e-1 (AD)  1.251e-1 (ND)   (Frontal_Cortex)
1.405e-1 (AD)  2.412e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs755016chr11:70106456 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCARA50.749
COL15A10.745
SLC47A10.723
PLA2R10.722
NMUR10.701
TNFRSF190.687
CXCL120.683
COL14A10.681
ATP2A30.677
LGI20.668

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.438
KLF15-0.403
C7orf61-0.395
MGST1-0.39
GABRG1-0.382
BGLAP-0.377
CYP2J2-0.376
IZUMO4-0.363
SDC4-0.361
NPIPB6-0.351

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04941CrofelemerSmall Molecule148465-45-6ApprovedTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ANO1 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ANO1 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of ANO1 mRNA"20406850
C0581765-nitro-2-(3-phenylpropylamino)benzoic acid5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of ANO1 protein24478309
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ANO1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ANO1 mRNA23630614
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ANO1 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ANO1 mRNA21298039
D001151ArsenicArsenic results in increased methylation of ANO1 promoter21291286
D001280AtrazineAtrazine results in increased expression of ANO1 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANO1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ANO1 mRNA22228805|2590861
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of ANO1 mRNA]20404318
D004958EstradiolEstradiol results in increased expression of ANO1 mRNA23019147
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ANO1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of ANO1 mRNA19371625|2301914
C006780bisphenol Abisphenol A affects the expression of ANO1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ANO1 mRNA26496021
D000001CalcimycinCalcimycin results in decreased activity of ANO1 protein24478309
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ANO1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ANO1 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO1 mRNA20938992
D019327Copper SulfateCopper Sulfate affects the expression of ANO1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of ANO1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of ANO1 mRNA27989131
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ANO1 mRNA]27941970
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ANO1 mRNA19371625
C067648digallic aciddigallic acid results in decreased activity of ANO1 protein24478309
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of ANO1 protein"24478309
C017435enilconazoleenilconazole results in decreased expression of ANO1 mRNA29106682
C045651epigallocatechin gallateepigallocatechin gallate results in decreased activity of ANO1 protein24478309
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ANO1 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ANO1 mRNA17555576
D015025ZearalenoneZearalenone results in increased expression of ANO1 mRNA19371625
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ANO1 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO1 mRNA20938992
C039281furanfuran results in increased expression of ANO1 mRNA27387713
D019833GenisteinGenistein results in increased expression of ANO1 mRNA19371625|2301914
C004312glycidolglycidol results in decreased expression of ANO1 mRNA24915197
D017313FenretinideFenretinide results in increased expression of ANO1 mRNA28973697
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ANO1 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ANO1 mRNA24796395|2511904
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ANO1 mRNA24231268
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ANO1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO1 mRNA20938992
D009544Niflumic AcidNiflumic Acid results in decreased activity of ANO1 protein24478309
C016340o,p'-DDT"o,p'-DDT results in increased expression of ANO1 mRNA"19371625
D009966OrphenadrineOrphenadrine affects the expression of ANO1 mRNA23665939
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ANO1 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of ANO1 mRNA25119042
D011441PropylthiouracilPropylthiouracil results in decreased expression of ANO1 mRNA24780913
D011794QuercetinQuercetin results in decreased activity of ANO1 protein25967872
C059514resveratrolresveratrol results in increased expression of ANO1 mRNA19371625
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ANO1 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of ANO1 gene28589171
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ANO1 mRNA"26680231
C578466T16AInh-A01T16AInh-A01 results in decreased activity of ANO1 protein24478309
D013629TamoxifenTamoxifen affects the expression of ANO1 mRNA17555576
C024746tobacco tartobacco tar results in decreased expression of ANO1 mRNA19559774
D014212TretinoinTretinoin results in increased expression of ANO1 mRNA23830798
C012589trichostatin Atrichostatin A results in decreased expression of ANO1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of ANO1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of ANO1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of ANO1 mRNA24896083
D014635Valproic AcidValproic Acid results in decreased expression of ANO1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ANO1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005227calcium activated cation channel activity-IDA22946059  
GO:0005229intracellular calcium activated chloride channel activity-IDA21984732  
GO:0005229intracellular calcium activated chloride channel activity-IMP22178883  22946059  
GO:0005229intracellular calcium activated chloride channel activity-ISS-  
GO:0005229intracellular calcium activated chloride channel activity-TAS-  
GO:0005247voltage-gated chloride channel activity-ISS-  
GO:0005254chloride channel activity-IMP24885604  
GO:0005515protein binding-IPI22178883  
GO:0015111iodide transmembrane transporter activity-IMP25201006  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006812cation transport-IDA22946059  
GO:0006821chloride transport-IMP22946059  
GO:0006821chloride transport-ISS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-ISS-  
GO:0007275multicellular organism development-IEA-  
GO:0015705iodide transport-IMP25201006  
GO:0034220ion transmembrane transport-TAS-  
GO:0034605cellular response to heat-ISS-  
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus-IGI24885604  
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus-IMP24885604  
GO:0050965detection of temperature stimulus involved in sensory perception of pain-ISS-  
GO:1902476chloride transmembrane transport-IMP24885604  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IDA21984732  22178883  22946059  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0016324apical plasma membrane-IDA25201006  
GO:0034707chloride channel complex-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27750372Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma. (2017 Mar)Pattle SBGenes Chromosomes Cancer