Gene: HEATR1

55127
BAP28|UTP10
HEAT repeat containing 1
protein-coding
1q43
Ensembl:ENSG00000119285 Vega:OTTHUMG00000040061 UniprotKB:Q9H583
NC_000001.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.115e-1 (AD)  9.328e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6661946chr1:236559808 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIAA05860.894
CEPT10.894
FAM208B0.886
PROSER10.884
NUP1530.883
POLH0.883
EPG50.881
DENND4A0.88
TSTD20.879
CNOT10.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.372
OR4F5-0.36
RBP1-0.331
OR4F29-0.323
KLRC2-0.32
KLRC3-0.317
APOA1-0.294
BCL7C-0.29
HMX1-0.289
BTBD17-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of HEATR1 mRNA"26377693
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HEATR1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HEATR1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEATR1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of HEATR1 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEATR1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of HEATR1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of HEATR1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of HEATR1 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HEATR1 mRNA24449571
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HEATR1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HEATR1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of HEATR1 mRNA26001963
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HEATR1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HEATR1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HEATR1 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HEATR1 mRNA"26238291
D004958EstradiolEstradiol results in increased expression of HEATR1 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of HEATR1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of HEATR1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of HEATR1 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HEATR1 mRNA23741332
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of HEATR1 mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HEATR1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of HEATR1 mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of HEATR1 mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of HEATR1 mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of HEATR1 mRNA27594783
D004041Dietary FatsDietary Fats affects the expression of HEATR1 mRNA19680557
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HEATR1 protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HEATR1 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of HEATR1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of HEATR1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of HEATR1 mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of HEATR1 mRNA26705709
D005839GentamicinsGentamicins results in increased expression of HEATR1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of HEATR1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HEATR1 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HEATR1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of HEATR1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HEATR1 mRNA25982114
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HEATR1 mRNA22235868
D008345ManganeseManganese results in increased expression of HEATR1 mRNA18284614
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HEATR1 mRNA26272509
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HEATR1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HEATR1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HEATR1 mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in increased expression of HEATR1 mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of HEATR1 mRNA24205000
D000073878Palm OilPalm Oil affects the expression of HEATR1 mRNA19680557
D010936Plant ExtractsPlant Extracts results in increased expression of HEATR1 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of HEATR1 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of HEATR1 mRNA19690047
D011794QuercetinQuercetin results in decreased expression of HEATR1 mRNA21632981
C016104sodium bichromatesodium bichromate results in increased expression of HEATR1 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of HEATR1 mRNA25993096
D018038Sodium SeleniteSodium Selenite results in increased expression of HEATR1 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HEATR1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HEATR1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of HEATR1 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of HEATR1 mRNA23411599
C483909torcetrapibtorcetrapib results in increased expression of HEATR1 mRNA23228038
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEATR1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of HEATR1 mRNA26272509
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of HEATR1 mRNA19042947
D014520UrethaneUrethane results in decreased expression of HEATR1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of HEATR1 mRNA23179753
C025643vinclozolinvinclozolin results in decreased expression of HEATR1 mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of HEATR1 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of HEATR1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI22190034  
GO:0030515snoRNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006364rRNA processing-TAS-  
GO:0045943positive regulation of transcription by RNA polymerase I-IBA21873635  
GO:0045943positive regulation of transcription by RNA polymerase I-IMP17699751  
GO:2000234positive regulation of rRNA processing-IMP17699751  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA17699751  
GO:0005739mitochondrion-IDA-  
GO:0016020membrane-HDA19946888  
GO:003068690S preribosome-IBA21873635  
GO:0032040small-subunit processome-IBA21873635  
GO:0034455t-UTP complex-IBA21873635  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
Reactome ID Reactome Term Evidence
R-HSA-6790901rRNA modification in the nucleus and cytosolIEA
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72312rRNA processingIEA
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolIEA
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNAIEA
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal