Gene: SRBD1

55133
-
S1 RNA binding domain 1
protein-coding
2p21
Ensembl:ENSG00000068784 Vega:OTTHUMG00000128814 UniprotKB:Q8N5C6
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.624e-1 (AD)  1.766e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2216506chr2:45408326 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1680.806
CTSO0.788
LYPLAL10.777
UEVLD0.771
IMPACT0.758
TMEM2090.731
ENTPD50.725
ABCD30.725
SLC35A30.723
MFSD10.723

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPPIN-0.397
CELSR1-0.364
RAX2-0.36
NPC1L1-0.354
TLR9-0.351
FOXD4L1-0.349
OR4F5-0.349
OR4F29-0.343
TJP3-0.33
CLDN9-0.325

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of SRBD1 mRNA29067470
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SRBD1 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SRBD1 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of SRBD1 mRNA21179406
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SRBD1 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in decreased expression of SRBD1 mRNA24386269
D016572CyclosporineCyclosporine results in increased expression of SRBD1 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of SRBD1 mRNA25270620
D002945CisplatinCisplatin results in decreased expression of SRBD1 mRNA19561079
C118739entinostatentinostat results in increased expression of SRBD1 mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SRBD1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SRBD1 mRNA22079256
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRBD1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SRBD1 mRNA23086925
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SRBD1 mRNA"25554681|2562005
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SRBD1 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of SRBD1 mRNA24642059
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SRBD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SRBD1 mRNA22079256
D012999SomanSoman results in decreased expression of SRBD1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRBD1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRBD1 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SRBD1 mRNA25729387
D014520UrethaneUrethane results in decreased expression of SRBD1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SRBD1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SRBD1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IEA-  
GO:0003729mRNA binding-IBA21873635  
GO:0003735structural constituent of ribosome-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-IEA-  
GO:0006412translation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal