Gene info: ID 55135

Gene: WRAP53

GENE ID: 55135

Synonyms: DKCB3|TCAB1|WDR79

Description: WD repeat containing antisense to TP53

Gene type: protein-coding

Location: 17p13.1

dbXrefs: Ensembl:ENSG00000141499 MIM:612661 Vega:OTTHUMG00000134323 UniprotKB:Q9BUR4

RefSeq: NG_028245.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.690e-1 (AD) 7.848e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CWC25	0.826
XAB2	0.82
EIF3B	0.819
HM13	0.819
ADRM1	0.817
NSUN5	0.817
NGDN	0.817
TRMU	0.814
PSMC4	0.814
SAP30BP	0.813

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.49
OR4F29	-0.45
P2RY14	-0.329
MTRNR2L9	-0.278
RERGL	-0.266
DIO2	-0.261
OR4F16	-0.26
KLRB1	-0.26
IFNG	-0.257
MTRNR2L6	-0.246

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of WRAP53 mRNA"	23829299
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of WRAP53 mRNA"	19114083
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of WRAP53 mRNA	24449571
D001280	Atrazine	Atrazine results in increased expression of WRAP53 mRNA	25929836
D001280	Atrazine	Atrazine results in decreased expression of WRAP53 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of WRAP53 mRNA	22316170
C006780	bisphenol A	bisphenol A affects the expression of WRAP53 mRNA	21786754
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of WRAP53 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of WRAP53 mRNA	25181051
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of WRAP53 mRNA	28628672
D003976	Diazinon	Diazinon results in increased methylation of WRAP53 gene	22964155
D002117	Calcitriol	Calcitriol results in decreased expression of WRAP53 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of WRAP53 mRNA	21592394
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of WRAP53 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of WRAP53 mRNA	28628672
C045463	leflunomide	leflunomide results in decreased expression of WRAP53 mRNA	28988120
C410127	PCB 180	PCB 180 results in decreased expression of WRAP53 mRNA	23829299
C006253	pirinixic acid	pirinixic acid results in increased expression of WRAP53 mRNA	23811191
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of WRAP53 mRNA	21427059
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of WRAP53 mRNA	19244175
D012643	Selenium	Selenium results in increased expression of WRAP53 mRNA	19244175
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of WRAP53 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of WRAP53 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of WRAP53 mRNA	22574217
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of WRAP53 mRNA"	26179874
D014635	Valproic Acid	Valproic Acid affects the expression of WRAP53 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of WRAP53 mRNA	21427059
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of WRAP53 mRNA	19244175
D014810	Vitamin E	Vitamin E results in increased expression of WRAP53 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	IDA	19179534
GO:0003723	RNA binding	-	IPI	20351177
GO:0005515	protein binding	-	IPI	19179534 21072240 25467444
GO:0042802	identical protein binding	-	IPI	21072240
GO:0044877	protein-containing complex binding	-	IDA	25467444
GO:0051087	chaperone binding	-	IPI	25467444
GO:0070034	telomerase RNA binding	-	IPI	20351177 25467444

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007004	telomere maintenance via telomerase	-	IDA	23685356
GO:0007004	telomere maintenance via telomerase	-	IMP	23685356
GO:0007004	telomere maintenance via telomerase	-	TAS	25467444
GO:0032203	telomere formation via telomerase	-	IMP	19179534
GO:0051973	positive regulation of telomerase activity	-	IDA	19179534 23685356
GO:0051973	positive regulation of telomerase activity	-	IMP	23685356 25467444
GO:0090666	scaRNA localization to Cajal body	-	IMP	25467444
GO:0090671	telomerase RNA localization to Cajal body	-	HMP	25467444
GO:0090671	telomerase RNA localization to Cajal body	-	IMP	25467444
GO:1904851	positive regulation of establishment of protein localization to telomere	-	IMP	25467444
GO:1904867	protein localization to Cajal body	-	TAS	25467444

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	IDA	-
GO:0005697	telomerase holoenzyme complex	-	IDA	19179534
GO:0005829	cytosol	-	IDA	-
GO:0015030	Cajal body	-	IDA	19179534
GO:0015030	Cajal body	-	IMP	25467444
GO:0016604	nuclear body	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-157579	Telomere Maintenance	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-171319	Telomere Extension By Telomerase	TAS
R-HSA-180786	Extension of Telomeres	TAS
R-HSA-390466	Chaperonin-mediated protein folding	IEA
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	IEA
R-HSA-391251	Protein folding	IEA
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-73886	Chromosome Maintenance	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20301779	Dyskeratosis Congenita (1993)	Savage SA	-