Gene: CDCA8

55143
BOR|BOREALIN|DasraB|MESRGP
cell division cycle associated 8
protein-coding
1p34.3
Ensembl:ENSG00000134690 MIM:609977 Vega:OTTHUMG00000004320 UniprotKB:Q53HL2
NC_000001.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.146e-1 (AD)  5.477e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs531454chr1:37707925 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs615530chr1:37696022 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DFFB0.707
PPP1R3E0.707
CAPRIN20.707
RECQL50.706
POLL0.706
AP4B10.705
VIPAS390.705
RABL2B0.7
RABL2A0.697
LIG10.696

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRC2-0.327
DIO2-0.317
TSPAN12-0.309
OR4F5-0.3
ASB4-0.281
ENDOU-0.28
PLA2G5-0.276
TTLL10-0.269
OR4F29-0.267
MTRNR2L9-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CDCA8 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CDCA8 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDCA8 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CDCA8 mRNA"27291303
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDCA8 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDCA8 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDCA8 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDCA8 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of CDCA8 mRNA"20713471
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDCA8 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of CDCA8 mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDCA8 mRNA"23196670
D000082AcetaminophenAcetaminophen results in increased expression of CDCA8 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CDCA8 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDCA8 mRNA19770486
D001280AtrazineAtrazine results in increased expression of CDCA8 mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of CDCA8 mRNA22623647
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CDCA8 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDCA8 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDCA8 mRNA20064835
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDCA8 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDCA8 mRNA15034205|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDCA8 mRNA"19150397|2038263
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA24657404
D004958EstradiolEstradiol results in increased expression of CDCA8 mRNA19167446
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of CDCA8 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of CDCA8 mRNA25210133
C006780bisphenol Abisphenol A results in decreased expression of CDCA8 mRNA19490990|2927551
C006780bisphenol Abisphenol A results in increased expression of CDCA8 protein23142537
C006780bisphenol Abisphenol A results in decreased methylation of CDCA8 promoter27312807
C006780bisphenol Abisphenol A affects the expression of CDCA8 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CDCA8 mRNA25181051
D002104CadmiumCadmium results in decreased expression of CDCA8 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDCA8 mRNA26472689
D002220CarbamazepineCarbamazepine affects the expression of CDCA8 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CDCA8 mRNA17484886|2733941
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CDCA8 mRNA23650126
D002794CholineCholine affects the expression of CDCA8 mRNA17616785
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDCA8 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CDCA8 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDCA8 mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in decreased expression of CDCA8 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDCA8 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CDCA8 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CDCA8 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CDCA8 mRNA19159671|2163298
D003561CytarabineCytarabine results in decreased expression of CDCA8 mRNA17374387
D000069439DasatinibDasatinib results in decreased expression of CDCA8 mRNA20579391
D003976DiazinonDiazinon results in increased methylation of CDCA8 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDCA8 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDCA8 mRNA21266533
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of CDCA8 mRNA]21858171
D002945CisplatinCisplatin results in decreased expression of CDCA8 mRNA25270620
D004026DieldrinDieldrin results in increased expression of CDCA8 mRNA20438755
D004026DieldrinDieldrin results in increased expression of CDCA8 mRNA23153324
C014476diethyl maleatediethyl maleate results in increased expression of CDCA8 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDCA8 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDCA8 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDCA8 mRNA]17854601
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDCA8 mRNA18164116
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CDCA8 mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of CDCA8 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CDCA8 mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDCA8 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDCA8 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CDCA8 mRNA17351261
D005472FluorouracilFluorouracil results in decreased expression of CDCA8 mRNA17374387
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CDCA8 mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDCA8 mRNA20938992
D017313FenretinideFenretinide results in increased expression of CDCA8 mRNA28973697
D006918HydroxyureaHydroxyurea results in decreased expression of CDCA8 mRNA17374387
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CDCA8 mRNA22129741
D007213IndomethacinIndomethacin results in increased expression of CDCA8 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDCA8 mRNA25613284
C544151jinfukangjinfukang results in increased expression of CDCA8 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDCA8 mRNA24796395|2637803
C410337K 7174K 7174 results in decreased expression of CDCA8 mRNA24086573
D007854LeadLead affects the expression of CDCA8 mRNA28903495
C008261lead acetatelead acetate results in increased expression of CDCA8 mRNA21829687
C045463leflunomideleflunomide results in decreased expression of CDCA8 mRNA28988120
D008694MethamphetamineMethamphetamine results in decreased expression of CDCA8 mRNA25290377
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDCA8 mRNA20938992
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CDCA8 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of CDCA8 mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CDCA8 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDCA8 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CDCA8 mRNA24810058
C523184mocetinostatmocetinostat results in decreased expression of CDCA8 mRNA26378038
D009151Mustard GasMustard Gas results in decreased expression of CDCA8 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CDCA8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CDCA8 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of CDCA8 mRNA18978301
D009532NickelNickel results in increased expression of CDCA8 mRNA25583101
C570897NSC668394NSC668394 results in decreased expression of CDCA8 mRNA27137931
C016340o,p'-DDT"o,p'-DDT results in decreased expression of CDCA8 mRNA"18204070
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CDCA8 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CDCA8 mRNA25729387
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CDCA8 mRNA25658374
D010126OzoneOzone results in decreased expression of CDCA8 mRNA24336422
C500026palbociclibpalbociclib results in decreased expression of CDCA8 mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDCA8 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of CDCA8 mRNA23892564
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDCA8 mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of CDCA8 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of CDCA8 mRNA20403969
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDCA8 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CDCA8 mRNA18301758|2381119
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of CDCA8 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of CDCA8 mRNA21858171
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CDCA8 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CDCA8 mRNA22698814
D011374ProgesteroneProgesterone results in decreased expression of CDCA8 mRNA23012394|2301818
C005556propionaldehydepropionaldehyde results in decreased expression of CDCA8 mRNA26079696
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CDCA8 mRNA19167446
C059514resveratrolresveratrol results in increased expression of CDCA8 mRNA19167446
D012715Sesame OilSesame Oil results in decreased expression of CDCA8 mRNA29191790
C009250sevofluranesevoflurane results in increased expression of CDCA8 mRNA26206149
D012822Silicon DioxideSilicon Dioxide results in increased expression of CDCA8 mRNA25351596
C017947sodium arsenitesodium arsenite results in decreased expression of CDCA8 mRNA20371982
C017947sodium arsenitesodium arsenite results in decreased expression of CDCA8 mRNA17998272
D012999SomanSoman results in increased expression of CDCA8 mRNA19281266
D053260SootSoot results in increased expression of CDCA8 mRNA22461453|2655175
D013605T-2 ToxinT-2 Toxin results in increased expression of CDCA8 mRNA26141394
C501413tesaglitazartesaglitazar results in decreased expression of CDCA8 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CDCA8 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CDCA8 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDCA8 mRNA16714409
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDCA8 mRNA]15034205
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDCA8 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDCA8 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDCA8 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDCA8 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of CDCA8 mRNA23411599
C009495titanium dioxidetitanium dioxide affects the expression of CDCA8 mRNA17656681
C009495titanium dioxidetitanium dioxide results in increased expression of CDCA8 mRNA23557971
D014028Tobacco Smoke PollutionNFE2L2 protein promotes the reaction [Tobacco Smoke Pollution affects the expression of CDCA8 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CDCA8 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CDCA8 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CDCA8 mRNA25729387
D014112ToxapheneToxaphene results in decreased expression of CDCA8 mRNA23153324
D014212TretinoinTretinoin results in decreased expression of CDCA8 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased expression of CDCA8 mRNA25549359
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CDCA8 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDCA8 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of CDCA8 mRNA22378314
D014415TunicamycinTunicamycin results in decreased expression of CDCA8 mRNA17127020
D014520UrethaneUrethane results in increased expression of CDCA8 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of CDCA8 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CDCA8 gene25560391
D014747VinblastineCDCA8 protein affects the susceptibility to Vinblastine16217747
C029297vinylidene chloridevinylidene chloride results in increased expression of CDCA8 mRNA26682919
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDCA8 mRNA20370541
D015032ZincZinc deficiency results in increased expression of CDCA8 mRNA22171008
C088658zoledronic acidzoledronic acid results in decreased expression of CDCA8 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16239925  16291752  17099693  17956729  18243099  20739936  
21051298  24571573  25416956  29568061  
GO ID GO Term Qualifier Evidence PubMed
GO:0000070mitotic sister chromatid segregation-IBA21873635  
GO:0007080mitotic metaphase plate congression-IMP15260989  
GO:0051276chromosome organization-IMP15260989  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-IBA21873635  
GO:0000775chromosome, centromeric region-IDA15260989  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-TAS-  
GO:0010369chromocenter-IEA-  
GO:0030496midbody-IDA22724069  
GO:0032133chromosome passenger complex-IBA21873635  
GO:0032133chromosome passenger complex-IPI15260989  18591255  
GO:0032991protein-containing complex-IDA16239925  
GO:0045171intercellular bridge-IDA-  
GO:0051233spindle midzone-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4615885SUMOylation of DNA replication proteinsTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal