Gene: THAP1

55145
DYT6
THAP domain containing 1
protein-coding
8p11.21
Ensembl:ENSG00000131931 MIM:609520 Vega:OTTHUMG00000165276 UniprotKB:Q9NVV9
NG_011837.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.709e-1 (AD)  2.741e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C3orf380.851
SUGT10.839
THAP20.837
PAPOLA0.825
XPO10.812
NOL110.812
NUDT90.807
CCT30.802
PPP4R20.802
BAG20.802

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.526
OR4F29-0.472
LAMC3-0.345
UPB1-0.321
CNGA1-0.31
COX4I2-0.302
IL18RAP-0.293
MYLK2-0.293
SLC6A13-0.286
ANPEP-0.277

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of THAP1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of THAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of THAP1 mRNA"27188386
D000393Air Pollutants[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of THAP1 3' UTR28843141
D001280AtrazineAtrazine results in increased expression of THAP1 mRNA25929836
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of THAP1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of THAP1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of THAP1 mRNA22228805
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of THAP1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of THAP1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of THAP1 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of THAP1 mRNA23410634
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of THAP1 promoter22457795
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of THAP1 gene20938992
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of THAP1 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of THAP1 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of THAP1 mRNA22077320
D016572CyclosporineCyclosporine results in increased expression of THAP1 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of THAP1 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of THAP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of THAP1 mRNA28628672
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of THAP1 mRNA24690739
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of THAP1 gene20938992
D006046GoldGold results in decreased expression of THAP1 mRNA25523186
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of THAP1 mRNA20044591|2341063
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of THAP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of THAP1 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of THAP1 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of THAP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of THAP1 mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of THAP1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of THAP1 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of THAP1 mRNA23649840
D009585Nitrogen Dioxide[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of THAP1 3' UTR28843141
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of THAP1 mRNA18593933
D012834SilverSilver results in decreased expression of THAP1 mRNA27131904
C017947sodium arsenitesodium arsenite affects the expression of THAP1 mRNA29319823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of THAP1 mRNA21570461
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of THAP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of THAP1 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of THAP1 mRNA"26179874
D014520UrethaneUrethane results in increased expression of THAP1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of THAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of THAP1 mRNA23179753
D024483Vitamin K 3Vitamin K 3 affects the expression of THAP1 mRNA23410634
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of THAP1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17003378  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IC-  
GO:0005515protein binding-IPI16189514  20200153  21516116  25416956  25910212  26871637  
27107014  
GO:0008270zinc ion binding-IDA15863623  18073205  
GO:0042802identical protein binding-IPI16189514  21516116  25416956  25910212  
GO:0042803protein homodimerization activity-IDA28299530  
GO:0043565sequence-specific DNA binding-IDA15863623  17003378  18073205  20010837  
GO:0043565sequence-specific DNA binding-IMP19182804  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA20976771  
GO:0001935endothelial cell proliferation-IMP17003378  
GO:0006351transcription, DNA-templated-IMP17003378  
GO:0006355regulation of transcription, DNA-templated-IMP17003378  
GO:0007049cell cycle-IEA-  
GO:0007346regulation of mitotic cell cycle-IMP17003378  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA17003378  
GO:0016605PML body-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23365103SGCE mutations cause psychiatric disorders: clinical and genetic characterization. (2013 Jan)Peall KJBrain