Gene info: ID 5516

Gene: PPP2CB

GENE ID: 5516

Synonyms: PP2Abeta|PP2CB

Description: protein phosphatase 2 catalytic subunit beta

Gene type: protein-coding

Location: 8p12

dbXrefs: Ensembl:ENSG00000104695 MIM:176916 Vega:OTTHUMG00000163949 UniprotKB:P62714

RefSeq: NC_000008.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.811e-1 (AD) 3.004e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C18orf32	0.939
SBDS	0.926
EIF1	0.921
SRP9	0.92
HMGB1	0.919
ST13	0.918
MPC1	0.913
CNBP	0.909
UBE2E1	0.906
RHOA	0.905

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.9
OR4F5	-0.886
CXCL17	-0.129
MROH9	-0.121
CEACAM6	-0.11
OR52Z1	-0.107
MTRNR2L3	-0.105
SFTPA1	-0.104
HOXC12	-0.104
CCL11	-0.102

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00163	Vitamin E	Small Molecule	59-02-9	Approved\|Nutraceutical	Target
DB14001	alpha-Tocopherol succinate	Small Molecule	4345-03-3	Approved\|Nutraceutical	Target
DB14002	D-alpha-Tocopherol acetate	Small Molecule	58-95-7	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PPP2CB mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PPP2CB mRNA"	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of PPP2CB mRNA	17562736
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of PPP2CB mRNA"	23195993
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PPP2CB mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of PPP2CB mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of PPP2CB gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PPP2CB mRNA	20458559
D001280	Atrazine	Atrazine results in increased expression of PPP2CB mRNA	22378314
C095105	bexarotene	bexarotene results in increased expression of PPP2CB mRNA	16648578
C006780	bisphenol A	bisphenol A affects the expression of PPP2CB mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of PPP2CB mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of PPP2CB mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of PPP2CB mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of PPP2CB mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PPP2CB gene	28505145
C022777	bufalin	bufalin results in decreased expression of PPP2CB protein	23091618
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of PPP2CB mRNA	12414654
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of PPP2CB promoter	22457795
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PPP2CB mRNA	27339419
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of PPP2CB mRNA	18636392
D003024	Clozapine	Clozapine results in decreased expression of PPP2CB mRNA	15860345
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PPP2CB mRNA	19376846
D003042	Cocaine	Cocaine results in decreased expression of PPP2CB mRNA	12629581
D003300	Copper	MT1 affects the reaction [Copper results in increased expression of PPP2CB mRNA]	16629173
D003300	Copper	MT2 affects the reaction [Copper results in increased expression of PPP2CB mRNA]	16629173
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PPP2CB mRNA	19549813
D016578	Crack Cocaine	Crack Cocaine results in increased expression of PPP2CB mRNA	12629581
D016572	Cyclosporine	Cyclosporine results in increased expression of PPP2CB mRNA	25562108
C014347	decitabine	decitabine results in increased expression of PPP2CB mRNA	27915011
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PPP2CB mRNA]	27941970
D003976	Diazinon	Diazinon results in increased methylation of PPP2CB gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PPP2CB mRNA	21266533
C100264	enniatins	enniatins results in decreased expression of PPP2CB mRNA	27163883
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of PPP2CB mRNA	23649840
D018120	Finasteride	Finasteride results in increased expression of PPP2CB mRNA	24136188
D005419	Flavonoids	Flavonoids results in decreased expression of PPP2CB mRNA	18035473
D005472	Fluorouracil	Fluorouracil results in increased expression of PPP2CB mRNA	16709241
D005485	Flutamide	Flutamide results in increased expression of PPP2CB mRNA	21126777
D005485	Flutamide	Flutamide results in increased expression of PPP2CB mRNA	24136188
D006220	Haloperidol	Haloperidol results in decreased expression of PPP2CB mRNA	15860345
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of PPP2CB mRNA	12414654
D015759	Ionomycin	PPP2CB protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein]	23775084
D015759	Ionomycin	PPP2CB protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of MAPK1 protein]	23775084
D015759	Ionomycin	PPP2CB protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of MAPK3 protein]	23775084
C410337	K 7174	K 7174 results in increased expression of PPP2CB mRNA	24086573
D007654	Ketoconazole	Ketoconazole results in decreased expression of PPP2CB mRNA	25787151
D007854	Lead	Lead affects the expression of PPP2CB mRNA	28903495
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of PPP2CB mRNA	20353558
D008727	Methotrexate	Methotrexate results in decreased expression of PPP2CB mRNA	24449571
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of PPP2CB mRNA	27544571
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PPP2CB mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium affects the expression of PPP2CB mRNA	12710931
D008825	Miconazole	Miconazole results in decreased expression of PPP2CB mRNA	22262564
C051752	nefazodone	nefazodone results in increased expression of PPP2CB mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of PPP2CB mRNA	23195993
D009534	Niclosamide	Niclosamide results in decreased expression of PPP2CB mRNA	22576131
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of PPP2CB mRNA	12102619
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of PPP2CB mRNA	17616710
C464660	obeticholic acid	obeticholic acid results in increased expression of PPP2CB mRNA	27939613
D010126	Ozone	"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of PPP2CB mRNA"	23246600
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of PPP2CB mRNA	18636392
D010269	Paraquat	Paraquat results in increased expression of PPP2CB mRNA	28619522
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of PPP2CB mRNA	18593933
D010634	Phenobarbital	Phenobarbital affects the expression of PPP2CB mRNA	19159669
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PPP2CB mRNA	19710929
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of PPP2CB mRNA	22714537
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of PPP2CB mRNA	19162173
C059514	resveratrol	resveratrol inhibits the reaction [Streptozocin results in increased expression of PPP2CB protein]	19690068
C059514	resveratrol	resveratrol results in decreased expression of PPP2CB protein	19690068
D012834	Silver	Silver results in increased expression of PPP2CB mRNA	26014281
D013311	Streptozocin	resveratrol inhibits the reaction [Streptozocin results in increased expression of PPP2CB protein]	19690068
D013311	Streptozocin	Streptozocin results in increased expression of PPP2CB protein	19690068
D013467	Sulindac	Sulindac results in increased expression of PPP2CB mRNA	24136188
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PPP2CB mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	PPP2CB protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein]	23775084
D013755	Tetradecanoylphorbol Acetate	PPP2CB protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of MAPK1 protein]	23775084
D013755	Tetradecanoylphorbol Acetate	PPP2CB protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of MAPK3 protein]	23775084
C014215	tetrahydropalmatine	tetrahydropalmatine results in decreased expression of PPP2CB protein	20109541
D013853	Thioacetamide	Thioacetamide results in increased expression of PPP2CB mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of PPP2CB mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of PPP2CB mRNA	28065790
D014241	Trichloroethylene	Trichloroethylene results in increased expression of PPP2CB mRNA	19448997
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PPP2CB mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of PPP2CB mRNA	17127020
C501517	UCF 101	UCF 101 results in decreased expression of PPP2CB protein	19690068
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of PPP2CB mRNA	12414654
D014873	Water Pollutants	Water Pollutants results in decreased expression of PPP2CB mRNA	23591932
D014874	Water Pollutants, Chemical	"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of PPP2CB mRNA"	23246600
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of PPP2CB mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004722	protein serine/threonine phosphatase activity	-	ISS	-
GO:0004722	protein serine/threonine phosphatase activity	-	TAS	10640627 16262633
GO:0004722	protein serine/threonine phosphatase activity	contributes_to	TAS	8206937
GO:0005515	protein binding	-	IPI	9647778 10698523 15936019 17353931 18782753 19156129 20969868 21784977 23455922 25531779 26496610 27107014 27173435 28330616
GO:0008022	protein C-terminus binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006470	protein dephosphorylation	-	TAS	2849765
GO:0008637	apoptotic mitochondrial changes	-	IEA	-
GO:0010288	response to lead ion	-	ISS	-
GO:0010468	regulation of gene expression	-	IEA	-
GO:0034976	response to endoplasmic reticulum stress	-	IEA	-
GO:0035970	peptidyl-threonine dephosphorylation	-	TAS	16262633
GO:0042542	response to hydrogen peroxide	-	IEA	-
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	IEA	-
GO:0046580	negative regulation of Ras protein signal transduction	-	IEA	-
GO:0070262	peptidyl-serine dephosphorylation	-	TAS	16262633
GO:1904528	positive regulation of microtubule binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000159	protein phosphatase type 2A complex	-	TAS	8206937
GO:0000775	chromosome, centromeric region	-	IEA	-
GO:0000922	spindle pole	-	IEA	-
GO:0005634	nucleus	-	IEA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa03015	mRNA surveillance pathway
hsa04114	Oocyte meiosis
hsa04310	Wnt signaling pathway
hsa04350	TGF-beta signaling pathway
hsa04530	Tight junction
hsa04730	Long-term depression
hsa05142	Chagas disease (American trypanosomiasis)
hsa05160	Hepatitis C

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-111885	Opioid Signalling	TAS
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	TAS
R-HSA-113510	E2F mediated regulation of DNA replication	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1295596	Spry regulation of FGF signaling	TAS
R-HSA-141424	Amplification of signal from the kinetochores	TAS
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-163685	Integration of energy metabolism	IEA
R-HSA-163767	PP2A-mediated dephosphorylation of key metabolic factors	IEA
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1640170	Cell Cycle	IEA
R-HSA-1643685	Disease	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-166520	Signaling by NTRKs	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-180024	DARPP-32 events	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-196299	Beta-catenin phosphorylation cascade	TAS
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	TAS
R-HSA-198753	ERK/MAPK targets	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	IEA
R-HSA-202670	ERKs are inactivated	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2465910	MASTL Facilitates Mitotic Progression	IEA
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-389513	CTLA4 inhibitory signaling	TAS
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-432142	Platelet sensitization by LDL	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	IEA
R-HSA-4791275	Signaling by WNT in cancer	TAS
R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	TAS
R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	TAS
R-HSA-4839744	truncated APC mutants destabilize the destruction complex	TAS
R-HSA-4839748	AMER1 mutants destabilize the destruction complex	TAS
R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	TAS
R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	TAS
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	TAS
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	TAS
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654727	Negative regulation of FGFR2 signaling	TAS
R-HSA-5654732	Negative regulation of FGFR3 signaling	TAS
R-HSA-5654733	Negative regulation of FGFR4 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5654741	Signaling by FGFR3	TAS
R-HSA-5654743	Signaling by FGFR4	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663220	RHO GTPases Activate Formins	TAS
R-HSA-5673000	RAF activation	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5675221	Negative regulation of MAPK pathway	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6804757	Regulation of TP53 Degradation	TAS
R-HSA-6806003	Regulation of TP53 Expression and Degradation	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-68875	Mitotic Prophase	IEA
R-HSA-68877	Mitotic Prometaphase	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-68886	M Phase	IEA
R-HSA-69206	G1/S Transition	TAS
R-HSA-69231	Cyclin D associated events in G1	TAS
R-HSA-69236	G1 Phase	TAS
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69278	Cell Cycle, Mitotic	IEA
R-HSA-69618	Mitotic Spindle Checkpoint	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-70171	Glycolysis	IEA
R-HSA-70326	Glucose metabolism	IEA
R-HSA-71387	Metabolism of carbohydrates	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20887155	Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. (2010 Dec)	Edmiston JS	Biomarkers