Gene: PNPO

55163
HEL-S-302|PDXPO
pyridoxamine 5'-phosphate oxidase
protein-coding
17q21.32
Ensembl:ENSG00000108439 MIM:603287 Vega:OTTHUMG00000178295 UniprotKB:Q9NVS9
NG_008744.1
PubMed
0   ANCO-SNPs
ND
1   
9.202e-1 (AD)  2.502e-1 (ND)   (Frontal_Cortex)
9.368e-2 (AD)  1.112e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PFKM0.89
NDUFS10.888
LONP20.886
MIEF10.88
ASTN10.879
GSR0.876
USP220.87
TRAK10.87
DDB10.869
GLYR10.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.539
OR4F29-0.485
SH2D1A-0.434
KLRK1-0.431
CTNNA3-0.423
SPINK8-0.417
MTRNR2L6-0.4
GNG8-0.389
FMO3-0.387
SGMS2-0.38

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB03247Flavin mononucleotideSmall Molecule146-17-8Approved|InvestigationalTarget
DB03345Beta-MercaptoethanolSmall Molecule60-24-2ExperimentalTarget
DB02209Pyridoxine phosphateSmall Molecule447-05-2ExperimentalEnzyme
ID Drug Name Action PubMed
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PNPO protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of PNPO mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNPO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNPO mRNA"27188386
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PNPO protein"24455688
D000082AcetaminophenAcetaminophen results in decreased expression of PNPO mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PNPO protein20106945
C006632arsenic trioxidePNPO protein results in decreased susceptibility to arsenic trioxide20707922
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PNPO mRNA20064835
D004958EstradiolEstradiol affects the expression of PNPO mRNA23557687
C006780bisphenol Abisphenol A results in increased expression of PNPO mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PNPO protein24527689
D002994ClofibrateClofibrate results in decreased expression of PNPO protein16470657
C018021cobaltous chloridecobaltous chloride results in decreased expression of PNPO mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of PNPO mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PNPO mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of PNPO mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PNPO mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PNPO mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PNPO mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PNPO mRNA27392435
D002945CisplatinCisplatin results in increased expression of PNPO mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of PNPO mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PNPO mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of PNPO mRNA]19850644
C118739entinostatentinostat results in increased expression of PNPO mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PNPO protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PNPO mRNA17942748
C069837fullerene C60fullerene C60 results in increased expression of PNPO mRNA19167457
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PNPO mRNA27392435
D007854LeadLead affects the expression of PNPO mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PNPO mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PNPO mRNA23649840
C028007nickel monoxidenickel monoxide results in increased expression of PNPO mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PNPO mRNA20971185
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PNPO mRNA23948077
C031181phenanthrenephenanthrene results in increased expression of PNPO mRNA19457238
D010634PhenobarbitalPhenobarbital results in increased expression of PNPO mRNA19162173
D010862PilocarpinePilocarpine results in increased expression of PNPO protein19356691
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PNPO mRNA19162173
D011441PropylthiouracilPropylthiouracil results in decreased expression of PNPO mRNA24780913
C059514resveratrolresveratrol results in decreased expression of PNPO protein23724044
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PNPO mRNA21427059
C009277sodium arsenatesodium arsenate results in decreased expression of PNPO mRNA23922661
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to PNPO gene]28681081
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PNPO mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PNPO mRNA17942748
C009495titanium dioxidetitanium dioxide results in increased expression of PNPO mRNA23131501
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PNPO mRNA29024780
D014520UrethaneUrethane results in decreased expression of PNPO mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNPO mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PNPO mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PNPO mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of PNPO mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004733pyridoxamine-phosphate oxidase activity-IBA21873635  
GO:0004733pyridoxamine-phosphate oxidase activity-IDA12824491  
GO:0004733pyridoxamine-phosphate oxidase activity-TAS-  
GO:0005515protein binding-IPI25910212  
GO:0010181FMN binding-IDA12824491  
GO:0030170pyridoxal phosphate binding-IDA12824491  
GO:0042803protein homodimerization activity-IDA12824491  
GO ID GO Term Qualifier Evidence PubMed
GO:0008615pyridoxine biosynthetic process-IEA-  
GO:0042816vitamin B6 metabolic process-TAS-  
GO:0042823pyridoxal phosphate biosynthetic process-IBA21873635  
GO:0042823pyridoxal phosphate biosynthetic process-IDA12824491  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00750Vitamin B6 metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-964975Vitamins B6 activation to pyridoxal phosphateTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17143180Association of genetic polymorphisms of ACADSB and COMT with human hypertension. (2007 Jan)Kamide KJ Hypertens