Gene: CEP55

55165
C10orf3|CT111|MARCH|URCC6
centrosomal protein 55
protein-coding
10q23.33
Ensembl:ENSG00000138180 MIM:610000 Vega:OTTHUMG00000018774 UniprotKB:Q53EZ4
NC_000010.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.366e-1 (AD)  9.862e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MKI670.8
TROAP0.789
RRM20.729
TOP2A0.684
KIF20A0.683
RNASE20.682
HIST1H3G0.678
UBE2C0.661
AURKB0.661
PLAC80.603

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSF-0.326
HES5-0.314
ATP2C2-0.307
WFDC1-0.298
C9orf24-0.29
HAGHL-0.29
CALML3-0.283
MMD2-0.278
WIF1-0.277
MESP2-0.276

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CEP55 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEP55 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of CEP55 mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CEP55 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEP55 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEP55 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEP55 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEP55 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of CEP55 mRNA25088246
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CEP55 mRNA"20816883
D000082AcetaminophenAcetaminophen results in increased expression of CEP55 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CEP55 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CEP55 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CEP55 mRNA23630614
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CEP55 mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in increased expression of CEP55 mRNA20458559
C015001arsenitearsenite results in decreased expression of CEP55 mRNA18929588
D001280AtrazineAtrazine results in increased expression of CEP55 mRNA25929836
D001379AzathioprineAzathioprine results in decreased expression of CEP55 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CEP55 mRNA20064835|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CEP55 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CEP55 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CEP55 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of CEP55 mRNA19167446
C044887beta-methylcholinebeta-methylcholine affects the expression of CEP55 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of CEP55 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CEP55 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of CEP55 mRNA25181051
D002104CadmiumCadmium results in decreased expression of CEP55 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CEP55 mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CEP55 mRNA17484886
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CEP55 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CEP55 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of CEP55 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of CEP55 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CEP55 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CEP55 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CEP55 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of CEP55 mRNA26577399
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CEP55 promoter23359474
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CEP55 mRNA28962523
C000944dicrotophosdicrotophos results in decreased expression of CEP55 mRNA28302478
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CEP55 promoter23359474
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CEP55 mRNA24535843
D002117CalcitriolCalcitriol results in decreased expression of CEP55 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CEP55 mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CEP55 protein23301498
D000431EthanolEthanol results in decreased expression of CEP55 protein20621659
D005472FluorouracilFluorouracil results in decreased expression of CEP55 mRNA17039268
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CEP55 mRNA20938992
C039281furanfuran results in increased expression of CEP55 mRNA25539665
C492448ICG 001ICG 001 results in decreased expression of CEP55 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CEP55 mRNA25613284
C544151jinfukangjinfukang results in increased expression of CEP55 mRNA27392435
C410337K 7174K 7174 results in increased expression of CEP55 mRNA24086573
D007840LatexLatex analog results in increased expression of CEP55 mRNA24768652
D008154LucanthoneLucanthone results in decreased expression of CEP55 mRNA21148553
D008694MethamphetamineMethamphetamine results in decreased expression of CEP55 mRNA25290377
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CEP55 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CEP55 mRNA20713471
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CEP55 mRNA24810058
D008799MevinphosMevinphos results in increased expression of CEP55 mRNA25449601
D008799MevinphosMevinphos results in increased expression of CEP55 protein25449601
D009151Mustard GasMustard Gas results in decreased expression of CEP55 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CEP55 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CEP55 mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of CEP55 mRNA19812364
D009532NickelNickel results in increased expression of CEP55 mRNA25583101
C025589ochratoxin Aochratoxin A results in decreased acetylation of CEP55 promoter29098329
C025589ochratoxin A[ochratoxin A results in decreased acetylation of CEP55 promoter] which results in decreased expression of CEP55 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in decreased expression of CEP55 mRNA29098329
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CEP55 mRNA25658374
D010126OzoneOzone results in increased expression of CEP55 mRNA25658374
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of CEP55 mRNA]19555225
C500026palbociclibpalbociclib results in decreased expression of CEP55 mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEP55 mRNA"25510870
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CEP55 mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of CEP55 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CEP55 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CEP55 mRNA18301758
D010894PiroxicamPiroxicam results in decreased expression of CEP55 mRNA21858171
D011374ProgesteroneProgesterone results in decreased expression of CEP55 mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of CEP55 mRNA18070364
D011441PropylthiouracilPropylthiouracil affects the expression of CEP55 mRNA24780913
D011794QuercetinQuercetin results in increased expression of CEP55 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CEP55 mRNA19167446
C017947sodium arsenitesodium arsenite results in decreased expression of CEP55 mRNA17998272
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CEP55 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CEP55 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CEP55 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CEP55 mRNA21802500
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CEP55 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of CEP55 mRNA22659510|2341159
C009495titanium dioxidetitanium dioxide results in increased expression of CEP55 mRNA23557971
D014028Tobacco Smoke PollutionNFE2L2 protein promotes the reaction [Tobacco Smoke Pollution affects the expression of CEP55 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CEP55 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of CEP55 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CEP55 gene27618143
C012589trichostatin Atrichostatin A affects the expression of CEP55 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CEP55 mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of CEP55 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of CEP55 mRNA25979313
C029297vinylidene chloridevinylidene chloride results in increased expression of CEP55 mRNA26682919
C111237vorinostatvorinostat results in increased expression of CEP55 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of CEP55 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  17853893  18940611  19549727  20176808  21516116  
25416956  25910212  26638075  26871637  27107012  27107014  
GO ID GO Term Qualifier Evidence PubMed
GO:0000281mitotic cytokinesis-IBA21873635  
GO:0000281mitotic cytokinesis-IGI19638580  
GO:0000920cell separation after cytokinesis-IBA21873635  
GO:0000920cell separation after cytokinesis-IMP20616062  
GO:0006997nucleus organizationNOTIMP20616062  
GO:0007080mitotic metaphase plate congressionNOTIMP20616062  
GO:0014066regulation of phosphatidylinositol 3-kinase signaling-IEA-  
GO:0045184establishment of protein localization-IBA21873635  
GO:0045184establishment of protein localization-IMP23045692  
GO:0072001renal system development-IMP28264986  
GO:1904888cranial skeletal system development-IMP28264986  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IDA20186884  21399614  
GO:0005814centriole-IEA-  
GO:0005815microtubule organizing center-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0016020membrane-HDA19946888  
GO:0030496midbody-IBA21873635  
GO:0030496midbody-IDA20186884  21310966  28264986  
GO:0032154cleavage furrow-IEA-  
GO:0045171intercellular bridge-IEA-  
GO:0090543Flemming body-IDA18641129  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19287496FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. (2009)Gemenetzidis EPLoS One
22109759Linking expression of FOXM1, CEP55 and HELLS to tumorigenesis in oropharyngeal squamous cell carcinoma. (2011 Dec)Janus JRLaryngoscope