Gene info: ID 55170

Gene: PRMT6

GENE ID: 55170

Synonyms: HRMT1L6

Description: protein arginine methyltransferase 6

Gene type: protein-coding

Location: 1p13.3

dbXrefs: Ensembl:ENSG00000198890 MIM:608274 Vega:OTTHUMG00000010964 UniprotKB:Q96LA8

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD

# Publications: 1

Sherlock p-value : 9.769e-1 (AD) 7.847e-1 (ND) (Frontal_Cortex)

Pascal p-value : 5.931e-1 (AD) 4.791e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SUB1	0.86
TSPYL5	0.858
FBXO9	0.858
UBLCP1	0.858
TRAPPC13	0.856
ZNF544	0.855
UBE2N	0.852
GALNT11	0.85
FAM174A	0.85
SCOC	0.85

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.523
TNFRSF10D	-0.493
GPR4	-0.473
OR4F29	-0.466
CSAG1	-0.465
KCNE4	-0.443
FXYD3	-0.431
SERPINH1	-0.422
MLKL	-0.41
NID1	-0.408

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PRMT6 mRNA"	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of PRMT6 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of PRMT6 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PRMT6 mRNA	19770486
D001151	Arsenic	Arsenic affects the methylation of PRMT6 gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of PRMT6 mRNA	22378314
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRMT6 mRNA"	20382639
D001599	Berberine	Berberine results in increased expression of PRMT6 mRNA	27311644
D004958	Estradiol	Estradiol results in increased expression of PRMT6 mRNA	25210133
C044887	beta-methylcholine	beta-methylcholine affects the expression of PRMT6 mRNA	21179406
C006780	bisphenol A	bisphenol A results in decreased expression of PRMT6 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of PRMT6 mRNA	26063408
C006780	bisphenol A	bisphenol A results in decreased methylation of PRMT6 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of PRMT6 mRNA	25181051
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PRMT6 mRNA	24386269
D003042	Cocaine	Cocaine results in decreased expression of PRMT6 mRNA	27506785
D003042	Cocaine	PRMT6 protein affects the susceptibility to Cocaine	27506785
D003042	Cocaine	PRMT6 protein inhibits the reaction [Cocaine results in increased expression of SRCIN1 protein]	27506785
D003042	Cocaine	Cocaine results in decreased expression of PRMT6 mRNA	27506785
D003042	Cocaine	Cocaine results in decreased expression of PRMT6 protein	27506785
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of PRMT6 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of PRMT6 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of PRMT6 mRNA	19770486
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PRMT6 mRNA	21266533
D004026	Dieldrin	Dieldrin results in decreased expression of PRMT6 mRNA	23041725
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of PRMT6 mRNA	23649840
C000499	ferric oxide	ferric oxide analog results in decreased expression of PRMT6 mRNA	25086211
D005557	Formaldehyde	Formaldehyde results in decreased expression of PRMT6 mRNA	20655997
D007854	Lead	Lead results in increased expression of PRMT6 mRNA	19921347
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PRMT6 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PRMT6 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PRMT6 mRNA	23649840
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PRMT6 mRNA"	29244179
D010269	Paraquat	Paraquat results in decreased expression of PRMT6 mRNA	23613995
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of PRMT6 mRNA	23892564
C059514	resveratrol	resveratrol results in decreased expression of PRMT6 mRNA	19371625
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PRMT6 mRNA	21570461
C012589	trichostatin A	trichostatin A affects the expression of PRMT6 mRNA	28542535
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of PRMT6 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PRMT6 mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of PRMT6 mRNA	22378314
D014520	Urethane	Urethane results in decreased expression of PRMT6 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of PRMT6 mRNA	23179753

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003682	chromatin binding	-	IEA	-
GO:0005515	protein binding	-	IPI	16157300 16293633 16600869 23455924 25416956
GO:0008469	histone-arginine N-methyltransferase activity	-	EXP	19509293 22777353
GO:0008469	histone-arginine N-methyltransferase activity	-	IBA	21873635
GO:0008469	histone-arginine N-methyltransferase activity	-	IDA	23980157
GO:0008469	histone-arginine N-methyltransferase activity	-	TAS	-
GO:0016274	protein-arginine N-methyltransferase activity	-	TAS	-
GO:0035241	protein-arginine omega-N monomethyltransferase activity	-	IDA	11724789 16157300 16600869
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	-	IBA	21873635
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	-	IDA	11724789 16157300 17898714 18079182
GO:0042054	histone methyltransferase activity	-	IDA	19405910
GO:0042393	histone binding	-	IDA	17898714 18079182
GO:0044020	histone methyltransferase activity (H4-R3 specific)	-	IDA	18079182
GO:0070611	histone methyltransferase activity (H3-R2 specific)	-	IDA	17898714 18079182
GO:0070612	histone methyltransferase activity (H2A-R3 specific)	-	IDA	18079182

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006284	base-excision repair	-	TAS	16600869
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IBA	21873635
GO:0016032	viral process	-	IEA	-
GO:0016571	histone methylation	-	IDA	19405910
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	-	IBA	21873635
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	-	IDA	17898714 18079182
GO:0034969	histone arginine methylation	-	IBA	21873635
GO:0034970	histone H3-R2 methylation	-	IDA	17898714 18079182
GO:0043985	histone H4-R3 methylation	-	IEA	-
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	18079182
GO:0051572	negative regulation of histone H3-K4 methylation	-	IEA	-
GO:0090398	cellular senescence	-	IEA	-
GO:1901796	regulation of signal transduction by p53 class mediator	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	11724789
GO:0005654	nucleoplasm	-	TAS	-
GO:0005730	nucleolus	-	IDA	-
GO:0005829	cytosol	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3214858	RMTs methylate histone arginines	TAS
R-HSA-3247509	Chromatin modifying enzymes	TAS
R-HSA-4839726	Chromatin organization	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27506785	Histone arginine methylation in cocaine action in the nucleus accumbens. (2016 Aug 23)	Damez-Werno DM	Proc Natl Acad Sci U S A