Gene: PRMT6

55170
HRMT1L6
protein arginine methyltransferase 6
protein-coding
1p13.3
Ensembl:ENSG00000198890 MIM:608274 Vega:OTTHUMG00000010964 UniprotKB:Q96LA8
NC_000001.11
PubMed
CD
1   
9.769e-1 (AD)  7.847e-1 (ND)   (Frontal_Cortex)
5.931e-1 (AD)  4.791e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SUB10.86
TSPYL50.858
FBXO90.858
UBLCP10.858
TRAPPC130.856
ZNF5440.855
UBE2N0.852
GALNT110.85
FAM174A0.85
SCOC0.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.523
TNFRSF10D-0.493
GPR4-0.473
OR4F29-0.466
CSAG1-0.465
KCNE4-0.443
FXYD3-0.431
SERPINH1-0.422
MLKL-0.41
NID1-0.408

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PRMT6 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of PRMT6 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PRMT6 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRMT6 mRNA19770486
D001151ArsenicArsenic affects the methylation of PRMT6 gene25304211
D001280AtrazineAtrazine results in decreased expression of PRMT6 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRMT6 mRNA"20382639
D001599BerberineBerberine results in increased expression of PRMT6 mRNA27311644
D004958EstradiolEstradiol results in increased expression of PRMT6 mRNA25210133
C044887beta-methylcholinebeta-methylcholine affects the expression of PRMT6 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of PRMT6 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of PRMT6 mRNA26063408
C006780bisphenol Abisphenol A results in decreased methylation of PRMT6 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of PRMT6 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in increased expression of PRMT6 mRNA24386269
D003042CocaineCocaine results in decreased expression of PRMT6 mRNA27506785
D003042CocainePRMT6 protein affects the susceptibility to Cocaine27506785
D003042CocainePRMT6 protein inhibits the reaction [Cocaine results in increased expression of SRCIN1 protein]27506785
D003042CocaineCocaine results in decreased expression of PRMT6 mRNA27506785
D003042CocaineCocaine results in decreased expression of PRMT6 protein27506785
D019327Copper SulfateCopper Sulfate results in decreased expression of PRMT6 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PRMT6 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of PRMT6 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PRMT6 mRNA21266533
D004026DieldrinDieldrin results in decreased expression of PRMT6 mRNA23041725
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PRMT6 mRNA23649840
C000499ferric oxideferric oxide analog results in decreased expression of PRMT6 mRNA25086211
D005557FormaldehydeFormaldehyde results in decreased expression of PRMT6 mRNA20655997
D007854LeadLead results in increased expression of PRMT6 mRNA19921347
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PRMT6 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PRMT6 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PRMT6 mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PRMT6 mRNA"29244179
D010269ParaquatParaquat results in decreased expression of PRMT6 mRNA23613995
D010416PentachlorophenolPentachlorophenol results in increased expression of PRMT6 mRNA23892564
C059514resveratrolresveratrol results in decreased expression of PRMT6 mRNA19371625
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRMT6 mRNA21570461
C012589trichostatin Atrichostatin A affects the expression of PRMT6 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PRMT6 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PRMT6 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of PRMT6 mRNA22378314
D014520UrethaneUrethane results in decreased expression of PRMT6 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of PRMT6 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0005515protein binding-IPI16157300  16293633  16600869  23455924  25416956  
GO:0008469histone-arginine N-methyltransferase activity-EXP19509293  22777353  
GO:0008469histone-arginine N-methyltransferase activity-IBA21873635  
GO:0008469histone-arginine N-methyltransferase activity-IDA23980157  
GO:0008469histone-arginine N-methyltransferase activity-TAS-  
GO:0016274protein-arginine N-methyltransferase activity-TAS-  
GO:0035241protein-arginine omega-N monomethyltransferase activity-IDA11724789  16157300  16600869  
GO:0035242protein-arginine omega-N asymmetric methyltransferase activity-IBA21873635  
GO:0035242protein-arginine omega-N asymmetric methyltransferase activity-IDA11724789  16157300  17898714  18079182  
GO:0042054histone methyltransferase activity-IDA19405910  
GO:0042393histone binding-IDA17898714  18079182  
GO:0044020histone methyltransferase activity (H4-R3 specific)-IDA18079182  
GO:0070611histone methyltransferase activity (H3-R2 specific)-IDA17898714  18079182  
GO:0070612histone methyltransferase activity (H2A-R3 specific)-IDA18079182  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006284base-excision repair-TAS16600869  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0016032viral process-IEA-  
GO:0016571histone methylation-IDA19405910  
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine-IBA21873635  
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine-IDA17898714  18079182  
GO:0034969histone arginine methylation-IBA21873635  
GO:0034970histone H3-R2 methylation-IDA17898714  18079182  
GO:0043985histone H4-R3 methylation-IEA-  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA18079182  
GO:0051572negative regulation of histone H3-K4 methylation-IEA-  
GO:0090398cellular senescence-IEA-  
GO:1901796regulation of signal transduction by p53 class mediator-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11724789  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27506785Histone arginine methylation in cocaine action in the nucleus accumbens. (2016 Aug 23)Damez-Werno DMProc Natl Acad Sci U S A