Gene: INTS10

55174
C8orf35|INT10
integrator complex subunit 10
protein-coding
8p21.3
Ensembl:ENSG00000104613 MIM:611353 Vega:OTTHUMG00000131065 UniprotKB:Q9NVR2
NC_000008.11
PubMed
0   ANCO-SNPs
OD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.061e-1 (AD)  3.590e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SF3B20.906
ILF20.902
MARK30.902
DDX50.901
ADIPOR10.899
UBE2R20.898
RBM220.897
PA2G40.897
EIF2B10.896
PPP6R30.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.774
OR4F29-0.747
RERGL-0.195
IFNG-0.181
TDGF1-0.177
IGF2-0.177
MTRNR2L6-0.172
KLRB1-0.171
MTRNR2L9-0.167
FOXS1-0.165

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of INTS10 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of INTS10 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of INTS10 mRNA21298039
C044887beta-methylcholinebeta-methylcholine affects the expression of INTS10 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of INTS10 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of INTS10 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of INTS10 mRNA25181051
D002104CadmiumCadmium results in decreased expression of INTS10 mRNA23256528
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of INTS10 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of INTS10 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of INTS10 mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of INTS10 mRNA]27941970
D004026DieldrinDieldrin results in decreased expression of INTS10 mRNA23041725
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of INTS10 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of INTS10 mRNA23649840
D005485FlutamideFlutamide results in increased expression of INTS10 mRNA24136188
D019833GenisteinGenistein results in increased expression of INTS10 protein24552547
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of INTS10 mRNA20044591
C410337K 7174K 7174 results in increased expression of INTS10 mRNA24086573
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of INTS10 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of INTS10 mRNA23649840
D010416PentachlorophenolPentachlorophenol results in decreased expression of INTS10 mRNA24642059
D010936Plant ExtractsPlant Extracts results in increased expression of INTS10 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of INTS10 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of INTS10 mRNA22079256
D012999SomanSoman results in decreased expression of INTS10 mRNA19281266
D013849ThimerosalThimerosal results in increased expression of INTS10 mRNA27188386
C012589trichostatin Atrichostatin A affects the expression of INTS10 mRNA28542535
D014635Valproic AcidValproic Acid results in increased expression of INTS10 mRNA23179753
C025643vinclozolinvinclozolin affects the expression of INTS10 mRNA19015723
D024483Vitamin K 3Vitamin K 3 affects the expression of INTS10 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16239144  
GO:0005515protein bindingcontributes_toIPI16239144  
GO ID GO Term Qualifier Evidence PubMed
GO:0016180snRNA processing-IDA16239144  
GO:0042795snRNA transcription by RNA polymerase II-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA23904267  
GO:0005654nucleoplasm-TAS-  
GO:0032039integrator complex-IDA16239144  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6807505RNA polymerase II transcribes snRNA genesTAS
R-HSA-6807505RNA polymerase II transcribes snRNA genesIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25555482Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. (2015 Mar 1)Gelernter JBiol Psychiatry