Gene: KLHL11

55175
-
kelch like family member 11
protein-coding
17q21.2
Ensembl:ENSG00000178502 Vega:OTTHUMG00000133506 UniprotKB:Q9NVR0
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.009e-1 (AD)  6.940e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17498875chr17:41853703 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRM50.923
PPM1E0.923
PLEKHM30.923
CDKL50.921
DCC0.907
LNPEP0.902
NEU30.9
STXBP50.9
PCDHAC20.9
NCR3LG10.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.525
RAB13-0.495
BCL7C-0.487
S100A1-0.482
RARRES2-0.48
MPST-0.469
PPP1R14B-0.461
COPZ2-0.456
AKR1C3-0.451
HIST1H1C-0.448

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of KLHL11 mRNA]"19467301
D004958EstradiolEstradiol results in increased expression of KLHL11 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of KLHL11 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of KLHL11 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of KLHL11 mRNA29097150
C018475butyraldehydebutyraldehyde results in increased expression of KLHL11 mRNA26079696
D019327Copper SulfateCopper Sulfate results in increased expression of KLHL11 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of KLHL11 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of KLHL11 mRNA]27941970
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of KLHL11 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of KLHL11 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of KLHL11 mRNA19467301
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of KLHL11 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KLHL11 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLHL11 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KLHL11 mRNA29097150
D008627Mercuric ChlorideMercuric Chloride affects the expression of KLHL11 mRNA20353558
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLHL11 mRNA19710929
D010938Plant OilsPlant Oils results in increased expression of KLHL11 mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of KLHL11 mRNA22714537
C031389resorcinolresorcinol results in decreased expression of KLHL11 mRNA22623647
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of KLHL11 mRNA19074003
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of KLHL11 mRNA18976794
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLHL11 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLHL11 mRNA17942748
D013853ThioacetamideThioacetamide results in increased expression of KLHL11 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of KLHL11 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KLHL11 mRNA"26179874
D014520UrethaneUrethane results in increased expression of KLHL11 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of KLHL11 gene29154799
D014635Valproic AcidValproic Acid affects the expression of KLHL11 mRNA17292431
D014638VanadatesVanadates results in decreased expression of KLHL11 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KLHL11 gene25560391
C025643vinclozolinvinclozolin results in increased expression of KLHL11 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0015629actin cytoskeleton-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal