Gene: PBRM1

55193
BAF180|PB1
polybromo 1
protein-coding
3p21.1
Ensembl:ENSG00000163939 MIM:606083 Vega:OTTHUMG00000152663 UniprotKB:Q86U86
NG_032108.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.273e-1 (AD)  4.186e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11715796chr3:52661634 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRPF4B0.929
SYNRG0.927
ITCH0.919
SETX0.91
VPS13C0.907
BIRC60.905
TRIP120.905
DHX150.903
PIKFYVE0.903
SEC24B0.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.554
OR4F29-0.537
S100A1-0.262
PLA2G5-0.254
NANOGNB-0.215
BTBD17-0.214
HES5-0.212
OR4F16-0.206
NXNL1-0.194
MTRNR2L10-0.193

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PBRM1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PBRM1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PBRM1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PBRM1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PBRM1 mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of PBRM1 mRNA26690555
C430898AGN 194204AGN 194204 results in increased expression of PBRM1 mRNA16339527
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PBRM1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of PBRM1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of PBRM1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PBRM1 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of PBRM1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of PBRM1 mRNA25181051
D002737ChloropreneChloroprene results in increased expression of PBRM1 mRNA23125180
D019327Copper SulfateCopper Sulfate results in decreased expression of PBRM1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PBRM1 mRNA20106945|2798913
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PBRM1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of PBRM1 mRNA25016146
D004237DiuronDiuron results in decreased expression of PBRM1 mRNA25152437
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PBRM1 mRNA22079256
D018120FinasterideFinasteride results in increased expression of PBRM1 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of PBRM1 mRNA22634610
D007213IndomethacinIndomethacin results in decreased expression of PBRM1 mRNA28201806
D008727MethotrexateMethotrexate results in increased expression of PBRM1 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PBRM1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PBRM1 mRNA26272509
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PBRM1 mRNA"26251327
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PBRM1 mRNA26924002
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PBRM1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of PBRM1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of PBRM1 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of PBRM1 mRNA]22629407
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PBRM1 mRNA"25510870
D010634PhenobarbitalPhenobarbital results in decreased expression of PBRM1 mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of PBRM1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PBRM1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PBRM1 mRNA22079256
C045950propiconazolepropiconazole results in decreased expression of PBRM1 mRNA21278054
D011794QuercetinQuercetin results in increased expression of PBRM1 protein15221776
C059514resveratrolresveratrol results in decreased expression of PBRM1 mRNA25905778
D013467SulindacSulindac results in decreased expression of PBRM1 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PBRM1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PBRM1 mRNA19465110
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PBRM1 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of PBRM1 mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of PBRM1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PBRM1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PBRM1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of PBRM1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PBRM1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003682chromatin binding-IBA21873635  
GO:0003682chromatin binding-NAS11078522  
GO:0005515protein binding-IPI11780067  12368262  15985610  20130577  22140357  27142060  
GO:0015616DNA translocase activityCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-TAS11078522  
GO:0006337nucleosome disassembly-IBA21873635  
GO:0006338chromatin remodeling-TAS11078522  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006368transcription elongation from RNA polymerase II promoter-IBA21873635  
GO:0008285negative regulation of cell proliferation-IMP21248752  
GO:0043044ATP-dependent chromatin remodeling-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosome-NAS11078522  
GO:0005654nucleoplasm-IDA-  
GO:0016586RSC-type complex-IBA21873635  
GO:0016586RSC-type complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24585446Genetic variants in the SWI/SNF complex and smoking collaborate to modify the risk of pancreatic cancer in a Chinese population. (2015 Sep)Zhu BMol Carcinog