Gene: PPP2R2A

5520
B55A|B55ALPHA|PR52A|PR55A|PR55alpha
protein phosphatase 2 regulatory subunit Balpha
protein-coding
8p21.2
Ensembl:ENSG00000221914 MIM:604941 Vega:OTTHUMG00000163850 UniprotKB:P63151
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.749e-1 (AD)  4.667e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3808565chr8:26370124 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
API50.93
CSE1L0.928
ARCN10.926
COPS20.922
ATG120.921
UBE2G10.92
PSMC60.914
MTMR20.913
TLK20.913
TRMT1L0.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.631
OR4F29-0.613
MTRNR2L10-0.316
MTRNR2L6-0.303
MTRNR2L9-0.293
ASB4-0.293
P2RY14-0.292
KLRB1-0.282
MTRNR2L2-0.271
NXNL1-0.269

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB025062,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PPP2R2A mRNA"19162173
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PPP2R2A mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PPP2R2A mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PPP2R2A mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PPP2R2A protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP2R2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP2R2A mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PPP2R2A mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PPP2R2A mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PPP2R2A mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PPP2R2A mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PPP2R2A mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PPP2R2A mRNA24449571
D001280AtrazineAtrazine results in increased expression of PPP2R2A mRNA22378314
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of PPP2R2A mRNA26377693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPP2R2A mRNA"20018196
D004958EstradiolEstradiol affects the expression of PPP2R2A mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of PPP2R2A mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of PPP2R2A mRNA25181051
D000069286BortezomibBortezomib results in increased expression of PPP2R2A mRNA20977926
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PPP2R2A mRNA20360939
D002166CamptothecinPPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AFX protein modified form]25772433
D002166CamptothecinPPP2R2A protein results in decreased susceptibility to Camptothecin25772433
D002220CarbamazepineCarbamazepine affects the expression of PPP2R2A mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PPP2R2A mRNA27339419
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PPP2R2A mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PPP2R2A mRNA]17585979
D003024ClozapineClozapine results in decreased expression of PPP2R2A mRNA15860345
D019327Copper SulfateCopper Sulfate results in increased expression of PPP2R2A mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PPP2R2A mRNA"19167446
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of PPP2R2A protein27393157
C057862cyanoginosin LRcyanoginosin LR results in increased expression of and affects the localization of PPP2R2A protein23436320
C057862cyanoginosin LRcyanoginosin LR affects the expression of PPP2R2A protein22000993
D016572CyclosporineCyclosporine results in increased expression of PPP2R2A mRNA20106945
D003703DemecolcineDemecolcine results in increased expression of PPP2R2A mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PPP2R2A mRNA27392435
D004008DiclofenacDiclofenac affects the expression of PPP2R2A mRNA24752500
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PPP2R2A mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PPP2R2A mRNA"22485181
D004237DiuronDiuron results in increased expression of PPP2R2A mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PPP2R2A protein23301498
D000431EthanolEthanol results in decreased expression of PPP2R2A mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PPP2R2A mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPP2R2A mRNA17942748
D005419FlavonoidsFlavonoids results in decreased expression of PPP2R2A mRNA18035473
D005485FlutamideFlutamide results in increased expression of PPP2R2A mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of PPP2R2A mRNA20655997
D005839GentamicinsGentamicins results in increased expression of PPP2R2A mRNA22061828
D006220HaloperidolHaloperidol results in decreased expression of PPP2R2A mRNA15860345
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PPP2R2A mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PPP2R2A mRNA27392435
C410337K 7174K 7174 results in increased expression of PPP2R2A mRNA24086573
D008701MethapyrileneMethapyrilene results in increased expression of PPP2R2A mRNA16393664
D008769MethylnitronitrosoguanidinePPP2R2A protein results in decreased susceptibility to Methylnitronitrosoguanidine25772433
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPP2R2A mRNA]12710931
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to PPP2R2A protein]17220478
D015741MetriboloneMetribolone results in decreased expression of PPP2R2A protein17152098
D016685MitomycinPPP2R2A protein results in decreased susceptibility to Mitomycin25772433
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PPP2R2A mRNA17616710
D015739NocodazolePPP2R2A results in decreased susceptibility to Nocodazole17724024
D010269ParaquatParaquat results in increased expression of PPP2R2A mRNA21371552
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of PPP2R2A mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PPP2R2A mRNA16221955
D010634PhenobarbitalPhenobarbital affects the expression of PPP2R2A mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of PPP2R2A mRNA18301758|2381119
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of PPP2R2A mRNA21427059
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPP2R2A mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PPP2R2A mRNA28065790
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP2R2A mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PPP2R2A mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PPP2R2A mRNA"26179874
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPP2R2A mRNA]12710931
D014635Valproic AcidValproic Acid results in decreased expression of PPP2R2A mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of PPP2R2A mRNA21427059
C025643vinclozolinvinclozolin results in decreased expression of PPP2R2A mRNA23034163
D015032ZincZinc deficiency results in decreased expression of PPP2R2A protein22689922

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004722protein serine/threonine phosphatase activityCONTRIBUTES_TOIBA21873635  
GO:0004722protein serine/threonine phosphatase activity-IDA1849734  
GO:0004722protein serine/threonine phosphatase activity-TAS-  
GO:0005515protein binding-IPI9847399  15761952  17245430  17529992  17540176  17632056  
18782753  19156129  19293187  19915589  20711181  23878394  
25816751  26496610  27173435  28330616  
GO:0019888protein phosphatase regulator activity-TAS1849734  
GO:0044877protein-containing complex binding-IEA-  
GO:0048156tau protein binding-IEA-  
GO:0051721protein phosphatase 2A binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TAS-  
GO:0000278mitotic cell cycle-IBA21873635  
GO:0006470protein dephosphorylation-IDA1849734  
GO:0032502developmental process-IBA21873635  
GO:0043278response to morphine-IEA-  
GO:0043666regulation of phosphoprotein phosphatase activity-IEA-  
GO:0070262peptidyl-serine dephosphorylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000159protein phosphatase type 2A complex-IBA21873635  
GO:0000159protein phosphatase type 2A complex-IDA1849734  17245430  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa03015mRNA surveillance pathway
hsa04530Tight junction
hsa05142Chagas disease (American trypanosomiasis)
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2995383Initiation of Nuclear Envelope ReformationTAS
R-HSA-2995410Nuclear Envelope ReassemblyTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-927802Nonsense-Mediated Decay (NMD)TAS
R-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal