Gene: RCBTB1

55213
CLLD7|CLLL7|GLP|RDEOA
RCC1 and BTB domain containing protein 1
protein-coding
13q14.2
Ensembl:ENSG00000136144 MIM:607867 Vega:OTTHUMG00000016915 UniprotKB:Q8NDN9
NG_046892.1
PubMed
0   ANCO-SNPs
ND
1   
5.262e-1 (AD)  1.934e-1 (ND)   (Frontal_Cortex)
8.622e-1 (AD)  5.816e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NBR10.873
SNX10.87
HSD17B40.862
DYNC1I20.861
USP160.858
HINT30.857
UFM10.855
RAD210.853
SAMD80.853
SGCB0.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.697
OR4F5-0.664
RNF223-0.213
MMP23B-0.202
MTRNR2L6-0.178
MTRNR2L10-0.173
OR4F16-0.173
WNT7B-0.171
PAX2-0.164
MTRNR2L9-0.158

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of RCBTB1 mRNA"22101062
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of RCBTB1 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RCBTB1 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of RCBTB1 mRNA"20638727
D000082AcetaminophenAcetaminophen results in increased expression of RCBTB1 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of RCBTB1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RCBTB1 protein20106945
D001151ArsenicArsenic affects the methylation of RCBTB1 gene25304211
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RCBTB1 mRNA18164116
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RCBTB1 mRNA"20382639
C006780bisphenol Abisphenol A affects the expression of RCBTB1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of RCBTB1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of RCBTB1 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of RCBTB1 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of RCBTB1 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of RCBTB1 mRNA20106945
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RCBTB1 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of RCBTB1 mRNA21658437
D004147DioxinsDioxins affects the expression of RCBTB1 mRNA20463971
C039281furanfuran results in decreased expression of RCBTB1 mRNA26194646
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of RCBTB1 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RCBTB1 mRNA23649840
D008942MitoxantroneRCBTB1 protein affects the susceptibility to Mitoxantrone16217747
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RCBTB1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of RCBTB1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of RCBTB1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of RCBTB1 mRNA23608068
D011794QuercetinQuercetin results in increased expression of RCBTB1 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of RCBTB1 mRNA23419489
D012969Sodium FluorideSodium Fluoride results in decreased expression of RCBTB1 mRNA27862939
C012589trichostatin Atrichostatin A results in increased expression of RCBTB1 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of RCBTB1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of RCBTB1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of RCBTB1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of RCBTB1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RCBTB1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0007049cell cycle-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24202307Genome-wide interaction study identifies RCBTB1 as a modifier for smoking effect on carotid intima-media thickness. (2014 Jan)Wang LArterioscler Thromb Vasc Biol