Gene: CASC1

55259
LAS1|PPP1R54
cancer susceptibility 1
protein-coding
12p12.1
Ensembl:ENSG00000118307 MIM:616906 Vega:OTTHUMG00000150195 UniprotKB:Q6TDU7
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
3.524e-1 (AD)  9.818e-2 (ND)   (Frontal_Cortex)
2.075e-1 (AD)  2.276e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM110.868
ABCA50.853
BBS70.853
GLMN0.852
MAD2L10.852
ZNF250.851
ZWILCH0.85
ASAH2B0.847
HMGCLL10.845
RWDD2A0.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WDR38-0.455
SYDE1-0.449
CCDC102A-0.445
EVC2-0.428
AJUBA-0.425
MTRNR2L8-0.422
C4orf19-0.421
NTN1-0.42
LYPD1-0.417
PDZK1IP1-0.416

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CASC1 mRNA"27291303
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CASC1 mRNA25088246
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CASC1 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CASC1 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of CASC1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CASC1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CASC1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of CASC1 mRNA26079696
D003471CuprizoneCuprizone results in increased expression of CASC1 mRNA26577399
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CASC1 mRNA19371625
C039281furanfuran results in increased expression of CASC1 mRNA25539665
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CASC1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CASC1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CASC1 mRNA"25554681
C005556propionaldehydepropionaldehyde results in increased expression of CASC1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of CASC1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CASC1 mRNA25895662
C017947sodium arsenitesodium arsenite affects the expression of CASC1 mRNA29319823
C017947sodium arsenitesodium arsenite affects the methylation of CASC1 gene28589171
C016104sodium bichromatesodium bichromate results in increased expression of CASC1 mRNA22561333
D053260SootSoot results in decreased expression of CASC1 mRNA26551751
D014635Valproic AcidValproic Acid results in decreased methylation of CASC1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of CASC1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CASC1 gene25560391
C111237vorinostatvorinostat results in increased expression of CASC1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16410263A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients. (2006 Jul)Manenti GCarcinogenesis