Gene: TMEM143

55260
-
transmembrane protein 143
protein-coding
19q13.33
Ensembl:ENSG00000161558 Vega:OTTHUMG00000183197 UniprotKB:Q96AN5
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.365e-1 (AD)  8.297e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3745720chr19:48332825 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCB80.875
SARS20.87
PPP1R3E0.87
RNF2150.863
CORO60.863
PLA2G60.863
BDH10.863
DENND6B0.862
SLC2A110.862
ULK30.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.554
OR4F5-0.505
KIAA0040-0.502
WWTR1-0.49
C9orf135-0.485
HAS2-0.479
PABPC4L-0.476
PLEKHA4-0.467
OR4F29-0.466
SPTLC3-0.46

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of TMEM143 mRNA25704631
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TMEM143 mRNA22100608
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of TMEM143 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMEM143 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of TMEM143 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TMEM143 mRNA26079696
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TMEM143 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of TMEM143 mRNA28302478
D017313FenretinideFenretinide results in increased expression of TMEM143 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TMEM143 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TMEM143 mRNA27392435
C544151jinfukangjinfukang results in increased expression of TMEM143 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of TMEM143 mRNA28988120
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMEM143 mRNA19710929
C017947sodium arsenitesodium arsenite results in decreased expression of TMEM143 mRNA25879800
D012969Sodium FluorideSodium Fluoride results in increased expression of TMEM143 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM143 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TMEM143 mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TMEM143 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of TMEM143 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of TMEM143 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal