Gene info: ID 55287

SNP ID	Position	Alleles	Trait	Variation Type
rs9871587	chr3:12755508 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg07908984	chr3:12800836	TMEM40	Promoter	2.342e-4	Alcohol use disorders	26763658

Gene Symbol	Pearson Correlation Coefficient
SPINK5	0.505
KRT78	0.475
MUC21	0.472
TMPRSS11B	0.471
CEACAM5	0.461
DSG3	0.455
CRNN	0.454
IVL	0.449
SPRR1A	0.448
TMPRSS11E	0.446

Gene Symbol	Pearson Correlation Coefficient
C12orf40	-0.228
CRYBB3	-0.213
NPIPB15	-0.204
VCX3A	-0.199
STMND1	-0.191
LENEP	-0.187
ACAD11	-0.186
OR6M1	-0.185
PIRT	-0.184
TP53TG3C	-0.183

DrugBank
CTD

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in decreased expression of TMEM40 mRNA"	24172598
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of TMEM40 mRNA	16788091
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM40 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM40 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM40 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM40 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of TMEM40 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TMEM40 mRNA	21641981\|2210060
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of TMEM40 mRNA"	25351596
D001554	Benzene	Benzene results in decreased expression of TMEM40 mRNA	15929907
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of TMEM40 mRNA	26377693
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of TMEM40 mRNA	26377693
D004958	Estradiol	Estradiol results in increased expression of TMEM40 mRNA	19484750
C006780	bisphenol A	bisphenol A results in decreased expression of TMEM40 mRNA	25181051
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMEM40 mRNA	20938992
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of TMEM40 mRNA	20971185
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of TMEM40 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of TMEM40 mRNA	27392435
D004041	Dietary Fats	[Dietary Fats co-treated with resveratrol] results in increased expression of TMEM40 mRNA	21852083
D002117	Calcitriol	Calcitriol results in increased expression of TMEM40 mRNA	16002434
D004237	Diuron	Diuron metabolite results in decreased expression of TMEM40 mRNA	24172598
D005472	Fluorouracil	Fluorouracil affects the expression of TMEM40 mRNA	16584549
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMEM40 mRNA	20938992
C039281	furan	furan results in increased expression of TMEM40 mRNA	27387713
D019833	Genistein	Genistein results in decreased expression of TMEM40 mRNA	20884965
D019833	Genistein	Genistein results in increased expression of TMEM40 mRNA	26865667
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of TMEM40 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TMEM40 mRNA	25982114
C008261	lead acetate	lead acetate results in decreased expression of TMEM40 mRNA	25270620
C042720	mercuric bromide	mercuric bromide results in increased expression of TMEM40 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM40 mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMEM40 mRNA	20938992
C523799	MRK 003	TMEM40 results in increased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TMEM40 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TMEM40 mRNA"	25554681
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of TMEM40 mRNA	20971185
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM40 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TMEM40 mRNA	26272509
C059514	resveratrol	[Dietary Fats co-treated with resveratrol] results in increased expression of TMEM40 mRNA	21852083
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TMEM40 mRNA	22300531\|2535159
C017947	sodium arsenite	sodium arsenite affects the methylation of TMEM40 gene	28589171
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TMEM40 mRNA	27913140
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TMEM40 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TMEM40 mRNA	27913140
C009495	titanium dioxide	titanium dioxide results in decreased expression of TMEM40 mRNA	23557971
D014635	Valproic Acid	Valproic Acid results in increased expression of TMEM40 mRNA	24383497

Gene: TMEM40

ANCO-SNPs

DNA Methylation

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

There is no DrugBank record for this gene !

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)