Gene: ACOXL

55289
-
acyl-CoA oxidase like
protein-coding
2q13
Ensembl:ENSG00000153093 Vega:OTTHUMG00000131257 UniprotKB:Q9NUZ1
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.083e-1 (AD)  9.393e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7572507chr2:110733154 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR3C20.475
SPIN30.473
MAST40.471
KY0.47
LNPEP0.47
MED12L0.47
ANKRD290.468
NFAT50.465
ABCG80.463
UBXN100.461

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG8-0.318
BCL7C-0.272
C7orf61-0.269
NMB-0.265
EIF4EBP1-0.264
CRYBB2-0.264
ZNF114-0.261
SGMS2-0.257
TMSB15A-0.254
VAX2-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of ACOXL mRNA"26377693
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACOXL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACOXL mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ACOXL mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ACOXL gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ACOXL mRNA21298039
D001151ArsenicArsenic affects the methylation of ACOXL gene25304211
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of ACOXL mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ACOXL mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ACOXL mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACOXL mRNA22316170
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ACOXL mRNA27858113
C006780bisphenol Abisphenol A results in increased methylation of ACOXL promoter27312807
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ACOXL promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of ACOXL mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ACOXL gene28505145
D002737ChloropreneChloroprene results in decreased expression of ACOXL mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ACOXL mRNA27858113
D016572CyclosporineCyclosporine results in increased methylation of ACOXL promoter27989131
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ACOXL promoter23359474
D004041Dietary FatsDietary Fats results in increased expression of ACOXL mRNA25016146
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ACOXL promoter23359474
C118739entinostatentinostat results in increased expression of ACOXL mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACOXL mRNA"27188386
D007213IndomethacinIndomethacin results in increased expression of ACOXL mRNA28201806
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ACOXL mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ACOXL mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ACOXL mRNA23649840
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ACOXL mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ACOXL mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ACOXL mRNA"25554681
D010416PentachlorophenolPentachlorophenol results in increased expression of ACOXL mRNA23892564
D011441PropylthiouracilPropylthiouracil results in decreased expression of ACOXL mRNA24780913
D053260SootSoot results in decreased expression of ACOXL mRNA26551751
C009495titanium dioxidetitanium dioxide results in decreased expression of ACOXL mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ACOXL mRNA20133372
D014635Valproic AcidValproic Acid results in increased expression of ACOXL mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ACOXL gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0003995acyl-CoA dehydrogenase activity-IBA21873635  
GO:0003997acyl-CoA oxidase activity-IBA21873635  
GO:0005504fatty acid binding-IBA21873635  
GO:0016402pristanoyl-CoA oxidase activity-TAS-  
GO:0050660flavin adenine dinucleotide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0033539fatty acid beta-oxidation using acyl-CoA dehydrogenase-IBA21873635  
GO:0033540fatty acid beta-oxidation using acyl-CoA oxidase-IBA21873635  
GO:0033540fatty acid beta-oxidation using acyl-CoA oxidase-TAS-  
GO:0055088lipid homeostasis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005777peroxisome-IBA21873635  
GO:0005782peroxisomal matrix-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-389887Beta-oxidation of pristanoyl-CoATAS
R-HSA-390918Peroxisomal lipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal