Gene: FBXW7

55294
AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4
F-box and WD repeat domain containing 7
protein-coding
4q31.3
Ensembl:ENSG00000109670 MIM:606278 Vega:OTTHUMG00000185246 UniprotKB:Q969H0
NG_029466.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.030e-1 (AD)  4.116e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIRAS20.917
RGS40.912
PIK3R10.911
RPH3A0.91
SYT10.909
NCALD0.903
CHN10.902
SERPINI10.901
NRN10.901
TBR10.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.532
OR4F29-0.513
TFPI2-0.51
C1orf87-0.487
WWTR1-0.48
ARHGEF5-0.478
EGFLAM-0.473
RHOD-0.472
CNN2-0.472
RNF135-0.47

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0979491,25-dihydroxyvitamin D"FBXW7 protein affects the reaction [1,25-dihydroxyvitamin D results in decreased degradation of and results in increased expression of MXD1 protein]"23112173
C0979491,25-dihydroxyvitamin D"FBXW7 protein affects the reaction [1,25-dihydroxyvitamin D results in increased degradation of and results in decreased expression of MYC protein]"23112173
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of FBXW7 mRNA16788091
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of FBXW7 mRNA"19561079
D000082AcetaminophenAcetaminophen results in increased expression of FBXW7 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FBXW7 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FBXW7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FBXW7 gene28458013
C006632arsenic trioxidearsenic trioxide results in increased expression of FBXW7 protein24801890
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FBXW7 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FBXW7 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FBXW7 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FBXW7 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FBXW7 mRNA"26238291
C006780bisphenol Abisphenol A results in increased expression of FBXW7 mRNA26063408
D000069286BortezomibBortezomib results in decreased expression of FBXW7 mRNA20977926
D019327Copper SulfateCopper Sulfate results in increased expression of FBXW7 mRNA19549813
D003513CycloheximideCycloheximide promotes the reaction [FBXW7 protein binds to and results in decreased expression of RICTOR protein]25897075
D016572CyclosporineCyclosporine results in increased expression of FBXW7 mRNA25562108
D003703DemecolcineDemecolcine results in increased expression of FBXW7 mRNA23649840
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of FBXW7 mRNA"25908611
D002945CisplatinCisplatin results in increased expression of FBXW7 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of FBXW7 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of FBXW7 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in decreased expression of FBXW7 mRNA]19030233
C024629dimethyl phthalatedimethyl phthalate affects the expression of FBXW7 mRNA26924002
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FBXW7 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of FBXW7 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of FBXW7 mRNA21126777
D005557FormaldehydeFormaldehyde results in decreased expression of FBXW7 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of FBXW7 mRNA23649840
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of FBXW7 mRNA19376150
D007213IndomethacinIndomethacin results in decreased expression of FBXW7 mRNA28201806
D007545IsoproterenolIsoproterenol results in decreased expression of FBXW7 mRNA20003209
C544151jinfukangjinfukang results in decreased expression of FBXW7 mRNA27392435
D018021Lithium ChlorideFBXW7 protein inhibits the reaction [Lithium Chloride results in increased expression of RICTOR protein]25897075
D008727MethotrexateFBXW7 gene mutant form promotes the reaction [Methotrexate results in decreased susceptibility to Methotrexate]17588203
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FBXW7 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FBXW7 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of FBXW7 mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FBXW7 mRNA26924002
C523799MRK 003FBXW7 gene mutant form results in decreased susceptibility to MRK 00317646409
C568376MT19c compoundMT19c compound results in increased expression of FBXW7 mRNA21781307
C029938nickel sulfateFBXW7 mRNA affects the reaction [nickel sulfate results in increased degradation of MYC protein]20046830
C029938nickel sulfateFBXW7 protein affects the reaction [nickel sulfate results in increased degradation of MYC protein]20046830
D010100OxygenFBXW7 mRNA affects the reaction [Oxygen deficiency results in increased degradation of MYC protein]20046830
D010100OxygenFBXW7 protein affects the reaction [Oxygen deficiency results in increased degradation of MYC protein]20046830
D052638Particulate MatterParticulate Matter results in decreased expression of FBXW7 mRNA28341207
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of FBXW7 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FBXW7 protein25092180
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of FBXW7 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of FBXW7 mRNA23091169
D010695PhlorhizinPhlorhizin results in decreased expression of FBXW7 mRNA22538082
C045950propiconazolepropiconazole results in decreased expression of FBXW7 mRNA21278054
D011794QuercetinQuercetin results in increased expression of FBXW7 mRNA20596804
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in decreased expression of FBXW7 mRNA]19030233
D012402RotenoneRotenone results in decreased expression of FBXW7 mRNA23186747
C417521SB 216763FBXW7 protein inhibits the reaction [SB 216763 results in increased expression of RICTOR protein]25897075
D012906SmokeSmoke affects the expression of FBXW7 mRNA23693141
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FBXW7 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FBXW7 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FBXW7 promoter]19654925
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FBXW7 mRNA28065790
C012589trichostatin Atrichostatin A affects the expression of FBXW7 mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of FBXW7 mRNA28973697
D014520UrethaneUrethane results in increased expression of FBXW7 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of FBXW7 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FBXW7 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of FBXW7 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI11533444  14603323  15070733  15103331  15611062  17157259  
17314511  17909182  19412162  20596027  20823234  21620836  
22307056  23022380  23108047  23791182  24000165  24344117  
25344755  27837025  29149593  
GO:0030332cyclin binding-IDA12628165  
GO:0030332cyclin binding-IPI17434132  
GO:0030674protein binding, bridging-IDA12628165  
GO:0031625ubiquitin protein ligase binding-IPI12628165  
GO:0042802identical protein binding-IPI21620836  23791182  
GO:0043130ubiquitin binding-IBA21873635  
GO:0050816phosphothreonine residue binding-IDA17434132  
GO:0097027ubiquitin-protein transferase activator activity-IDA12628165  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-TAS-  
GO:0001944vasculature development-TAS21123947  
GO:0007062sister chromatid cohesion-IMP15917200  
GO:0010868negative regulation of triglyceride biosynthetic process-ISS-  
GO:0010883regulation of lipid storage-ISS-  
GO:0010992ubiquitin recycling-IBA21873635  
GO:0016032viral process-IEA-  
GO:0016567protein ubiquitination-IDA12354302  15103331  
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-IDA15103331  17434132  
GO:0031398positive regulation of protein ubiquitination-IDA12628165  
GO:0032876negative regulation of DNA endoreduplication-IMP15917200  
GO:0032880regulation of protein localization-ISS-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0043687post-translational protein modification-TAS-  
GO:0045741positive regulation of epidermal growth factor-activated receptor activity-IDA20208556  
GO:0045746negative regulation of Notch signaling pathway-ISS-  
GO:0050821protein stabilization-IDA20208556  
GO:0051443positive regulation of ubiquitin-protein transferase activity-IDA12628165  
GO:0055088lipid homeostasis-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP20208556  
GO:1901800positive regulation of proteasomal protein catabolic process-IDA23858059  
GO:1902806regulation of cell cycle G1/S phase transition-TAS12628165  
GO:1903146regulation of autophagy of mitochondrion-IMP24912190  
GO:1903378positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway-IDA23858059  
GO:1903955positive regulation of protein targeting to mitochondrion-IMP24912190  
GO:2000060positive regulation of ubiquitin-dependent protein catabolic process-IDA20208556  
GO:2000346negative regulation of hepatocyte proliferation-ISS-  
GO:2000639negative regulation of SREBP signaling pathway-ISS-  
GO:2001205negative regulation of osteoclast development-IMP29149593  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA23858059  
GO:0005829cytosol-TAS-  
GO:0019005SCF ubiquitin ligase complex-IDA12628165  15103331  17434132  
GO:1990452Parkin-FBXW7-Cul1 ubiquitin ligase complex-IPI12628165  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644605FBXW7 Mutants and NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2644607Loss of Function of FBXW7 in Cancer and NOTCH1 SignalingTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-390466Chaperonin-mediated protein foldingIEA
R-HSA-390471Association of TriC/CCT with target proteins during biosynthesisIEA
R-HSA-391251Protein foldingIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26873401Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016 May)Sawada GGastroenterology