Gene info: ID 553

Gene: AVPR1B

GENE ID: 553

Synonyms: AVPR3|V1bR

Description: arginine vasopressin receptor 1B

Gene type: protein-coding

Location: 1q32.1

dbXrefs: Ensembl:ENSG00000198049 MIM:600264 Vega:OTTHUMG00000184377 UniprotKB:P47901

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.744e-1 (AD) NA (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg08709672	chr1:206224334	AVPR1B		1.500e-21	Smoking	27651444
cg20295214	chr1:206226794	AVPR1B		5.500e-15	Smoking	27651444
cg18992688	chr1:206223241	AVPR1B		1.800e-8	Smoking	27651444
cg20295214	chr1:206226794	AVPR1B		4.000e-14	Tobacco smoking	28225026
cg08709672	chr1:206224334	AVPR1B		2.750e-10	Tobacco smoking	28225026
cg08709672	chr1:206224334	AVPR1B		7.300e-25	Smoking	28686328
cg20295214	chr1:206226794	AVPR1B		1.630e-22	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NYAP2	0.578
ERVH48-1	0.557
ERVW-1	0.538
KCNH7	0.532
CCSER1	0.53
STH	0.528
CNTNAP5	0.525
OPRM1	0.514
RAPH1	0.507
XKR6	0.506

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AAMDC	-0.3
FAM89A	-0.298
COPZ2	-0.276
HRASLS2	-0.274
BCL7C	-0.273
ROM1	-0.272
ASF1B	-0.267
RARRES2	-0.266
APOM	-0.265
VAMP5	-0.265

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00035	Desmopressin	Small Molecule	16679-58-6	Approved	Target
DB00067	Vasopressin	Small Molecule	11000-17-2	Approved	Target
DB02638	Terlipressin	Small Molecule	14636-12-5	Approved\|Investigational	Target
DB05452	PH-284	Small Molecule	-	Investigational	Target
DB05455	SR 121463	Small Molecule	-	Investigational	Target

ID	Drug Name	Action	PubMed
C456029	1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide	"1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide results in decreased activity of AVPR1B protein"	15685210
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AVPR1B mRNA"	27291303
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AVPR1B mRNA"	19114083
D000081	Acetamides	Acetamides analog binds to and results in decreased activity of AVPR1B protein	20719508
D000082	Acetaminophen	Acetaminophen affects the expression of AVPR1B mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in decreased expression of AVPR1B mRNA	26690555
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of AVPR1B mRNA	21298039
D000638	Amiodarone	Amiodarone affects the expression of AVPR1B mRNA	25064622
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of AVPR1B mRNA	16483693
C006780	bisphenol A	bisphenol A affects the expression of AVPR1B mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of AVPR1B mRNA	25181051
D002746	Chlorpromazine	Chlorpromazine affects the expression of AVPR1B mRNA	25064622
D003300	Copper	[Copper co-treated with Dietary Sucrose] results in increased expression of AVPR1B mRNA	26033743
D016572	Cyclosporine	Cyclosporine affects the expression of AVPR1B mRNA	25064622
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of AVPR1B mRNA	23640034
D004026	Dieldrin	Dieldrin results in increased expression of AVPR1B mRNA	20682304
D019422	Dietary Sucrose	[Copper co-treated with Dietary Sucrose] results in increased expression of AVPR1B mRNA	26033743
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of AVPR1B mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of AVPR1B mRNA	15620428
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of AVPR1B mRNA	20170655
C074283	estradiol 3-benzoate	Tamoxifen inhibits the reaction [estradiol 3-benzoate results in increased expression of AVPR1B mRNA]	20170655
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of AVPR1B mRNA	25064622
C082360	fipronil	fipronil results in decreased expression of AVPR1B mRNA	23962444
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of AVPR1B mRNA	21782745
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of AVPR1B mRNA	16807920
C002385	linsidomine	linsidomine results in increased oxidation of AVPR1B protein	28086193
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of AVPR1B mRNA	21782745
C025256	nonylphenol	nonylphenol results in decreased expression of AVPR1B mRNA	15620428
D010269	Paraquat	Paraquat affects the expression of AVPR1B mRNA	25064622
D010269	Paraquat	Paraquat results in decreased expression of AVPR1B mRNA	17077588
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of AVPR1B mRNA	23608068
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of AVPR1B mRNA	24780913
D011799	Quinazolines	Quinazolines analog binds to and results in decreased activity of AVPR1B protein	20719508
D013629	Tamoxifen	Tamoxifen inhibits the reaction [estradiol 3-benzoate results in increased expression of AVPR1B mRNA]	20170655
D013752	Tetracycline	Tetracycline affects the expression of AVPR1B mRNA	25064622
D013853	Thioacetamide	Thioacetamide affects the expression of AVPR1B mRNA	25064622
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of AVPR1B gene	26756918
D014635	Valproic Acid	Valproic Acid affects the expression of AVPR1B mRNA	25064622
D014635	Valproic Acid	Valproic Acid results in decreased expression of AVPR1B mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of AVPR1B gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of AVPR1B mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of AVPR1B gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0005000	vasopressin receptor activity	-	IBA	21873635
GO:0005080	protein kinase C binding	-	TAS	10858434
GO:0042277	peptide binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001992	regulation of systemic arterial blood pressure by vasopressin	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007202	activation of phospholipase C activity	-	TAS	7805841
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	TAS	7929452
GO:0032870	cellular response to hormone stimulus	-	IBA	21873635
GO:0045907	positive regulation of vasoconstriction	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005768	endosome	-	TAS	10858434
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	7805841

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04270	Vascular smooth muscle contraction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-388479	Vasopressin-like receptors	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-5619099	Defective AVP causes neurohypophyseal diabetes insipidus (NDI)	TAS
R-HSA-5619102	SLC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25424692	Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. (2014 Oct)	Tsaprouni LG	Epigenetics