Gene: AVPR1B

553
AVPR3|V1bR
arginine vasopressin receptor 1B
protein-coding
1q32.1
Ensembl:ENSG00000198049 MIM:600264 Vega:OTTHUMG00000184377 UniprotKB:P47901
NC_000001.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.744e-1 (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08709672chr1:206224334AVPR1B1.500e-21Smoking27651444
cg20295214chr1:206226794AVPR1B5.500e-15Smoking27651444
cg18992688chr1:206223241AVPR1B1.800e-8Smoking27651444
cg20295214chr1:206226794AVPR1B4.000e-14Tobacco smoking28225026
cg08709672chr1:206224334AVPR1B2.750e-10Tobacco smoking28225026
cg08709672chr1:206224334AVPR1B7.300e-25Smoking28686328
cg20295214chr1:206226794AVPR1B1.630e-22Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NYAP20.578
ERVH48-10.557
ERVW-10.538
KCNH70.532
CCSER10.53
STH0.528
CNTNAP50.525
OPRM10.514
RAPH10.507
XKR60.506

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AAMDC-0.3
FAM89A-0.298
COPZ2-0.276
HRASLS2-0.274
BCL7C-0.273
ROM1-0.272
ASF1B-0.267
RARRES2-0.266
APOM-0.265
VAMP5-0.265

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00035DesmopressinSmall Molecule16679-58-6ApprovedTarget
DB00067VasopressinSmall Molecule11000-17-2ApprovedTarget
DB02638TerlipressinSmall Molecule14636-12-5Approved|InvestigationalTarget
DB05452PH-284Small Molecule-InvestigationalTarget
DB05455SR 121463Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C4560291-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide"1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide results in decreased activity of AVPR1B protein"15685210
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AVPR1B mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AVPR1B mRNA"19114083
D000081AcetamidesAcetamides analog binds to and results in decreased activity of AVPR1B protein20719508
D000082AcetaminophenAcetaminophen affects the expression of AVPR1B mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of AVPR1B mRNA26690555
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of AVPR1B mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of AVPR1B mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AVPR1B mRNA16483693
C006780bisphenol Abisphenol A affects the expression of AVPR1B mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of AVPR1B mRNA25181051
D002746ChlorpromazineChlorpromazine affects the expression of AVPR1B mRNA25064622
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of AVPR1B mRNA26033743
D016572CyclosporineCyclosporine affects the expression of AVPR1B mRNA25064622
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AVPR1B mRNA23640034
D004026DieldrinDieldrin results in increased expression of AVPR1B mRNA20682304
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of AVPR1B mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of AVPR1B mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of AVPR1B mRNA15620428
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of AVPR1B mRNA20170655
C074283estradiol 3-benzoateTamoxifen inhibits the reaction [estradiol 3-benzoate results in increased expression of AVPR1B mRNA]20170655
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AVPR1B mRNA25064622
C082360fipronilfipronil results in decreased expression of AVPR1B mRNA23962444
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of AVPR1B mRNA21782745
D007657Ketone BodiesKetone Bodies results in decreased expression of AVPR1B mRNA16807920
C002385linsidominelinsidomine results in increased oxidation of AVPR1B protein28086193
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of AVPR1B mRNA21782745
C025256nonylphenolnonylphenol results in decreased expression of AVPR1B mRNA15620428
D010269ParaquatParaquat affects the expression of AVPR1B mRNA25064622
D010269ParaquatParaquat results in decreased expression of AVPR1B mRNA17077588
D011192Potassium DichromatePotassium Dichromate results in increased expression of AVPR1B mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of AVPR1B mRNA24780913
D011799QuinazolinesQuinazolines analog binds to and results in decreased activity of AVPR1B protein20719508
D013629TamoxifenTamoxifen inhibits the reaction [estradiol 3-benzoate results in increased expression of AVPR1B mRNA]20170655
D013752TetracyclineTetracycline affects the expression of AVPR1B mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of AVPR1B mRNA25064622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of AVPR1B gene26756918
D014635Valproic AcidValproic Acid affects the expression of AVPR1B mRNA25064622
D014635Valproic AcidValproic Acid results in decreased expression of AVPR1B mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of AVPR1B gene29154799
D014635Valproic AcidValproic Acid affects the expression of AVPR1B mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AVPR1B gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0005000vasopressin receptor activity-IBA21873635  
GO:0005080protein kinase C binding-TAS10858434  
GO:0042277peptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001992regulation of systemic arterial blood pressure by vasopressin-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007202activation of phospholipase C activity-TAS7805841  
GO:0007204positive regulation of cytosolic calcium ion concentration-TAS7929452  
GO:0032870cellular response to hormone stimulus-IBA21873635  
GO:0045907positive regulation of vasoconstriction-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-TAS10858434  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS7805841  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04270Vascular smooth muscle contraction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388479Vasopressin-like receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5619099Defective AVP causes neurohypophyseal diabetes insipidus (NDI)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25424692Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. (2014 Oct)Tsaprouni LGEpigenetics