Gene: PPP3CA

5530
CALN|CALNA|CALNA1|CCN1|CNA1|IECEE|IECEE1|PPP2B
protein phosphatase 3 catalytic subunit alpha
protein-coding
4q24
Ensembl:ENSG00000138814 MIM:114105 Vega:OTTHUMG00000133839 UniprotKB:Q08209
NC_000004.12
PubMed
0   ANCO-SNPs
OD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.704e-1 (AD)  3.023e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP3R10.98
CHN10.972
TSPYL10.969
WASF10.961
NPTN0.958
PRKAR2B0.956
LRP110.955
SNAP250.953
REEP50.952
NECAB10.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.658
OR4F29-0.624
TFPI2-0.43
CSAG1-0.41
RUNX3-0.4
CNN2-0.396
RAI14-0.387
FZD10-0.386
AJUBA-0.375
KLRB1-0.374

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08231Myristic acidSmall Molecule544-63-8ExperimentalTarget
ID Drug Name Action PubMed
C0095361,2,3-trichloropropane"1,2,3-trichloropropane results in increased cleavage of and results in increased activity of PPP3CA protein"22952646
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PPP3CA mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PPP3CA mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PPP3CA mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PPP3CA mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP3CA mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PPP3CA mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of PPP3CA mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP3CA mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PPP3CA mRNA21420995|2570463
D000082AcetaminophenAcetaminophen affects the expression of PPP3CA mRNA17562736
D000086AcetazolamideAcetazolamide results in increased expression of PPP3CA mRNA19274763
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PPP3CA gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PPP3CA mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PPP3CA mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of PPP3CA mRNA17963750
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of PPP3CA mRNA27377005
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPP3CA mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPP3CA mRNA20504355|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPP3CA mRNA"19150397
C046412benzyl acetatebenzyl acetate results in increased cleavage of and results in increased activity of PPP3CA protein22952646
D004958EstradiolEstradiol results in decreased expression of PPP3CA mRNA21185374
D004958EstradiolEstradiol results in decreased expression of PPP3CA mRNA20068009
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of PPP3CA promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of PPP3CA mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA28628672
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of PPP3CA mRNA15878706
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PPP3CA mRNA12419474
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PPP3CA mRNA18560533
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PPP3CA mRNA12160620
D002193CantharidinCantharidin results in decreased activity of [PPP3CA protein binds to PPP3R1 protein]19880376
D002211CapsaicinPPP3CA protein affects the reaction [mustard oil inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]]17590514
D002220CarbamazepineCarbamazepine results in decreased expression of PPP3CA mRNA14642444
D002220CarbamazepineCarbamazepine results in decreased expression of PPP3CA protein14642444
C035377chlorendic acidchlorendic acid results in increased cleavage of and results in increased activity of PPP3CA protein22952646
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PPP3CA mRNA23650126
D004390ChlorpyrifosChlorpyrifos results in increased expression of PPP3CA mRNA20350560
D003024Clozapine[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein16033416
D003024ClozapineClozapine results in decreased expression of PPP3CA mRNA16033416
D003024ClozapineClozapine results in decreased expression of PPP3CA protein16033416
D003024ClozapineClozapine results in increased expression of PPP3CA mRNA12437575
D003042CocaineCocaine affects the expression of PPP3CA mRNA20187946
D003471CuprizoneCuprizone results in decreased expression of PPP3CA mRNA26577399
C057862cyanoginosin LRcyanoginosin LR results in decreased activity of [PPP3CA protein binds to PPP3R1 protein]19880376
D016572CyclosporineCyclosporine results in decreased activity of PPP3CA protein19553475
D016572CyclosporineCyclosporine results in decreased expression of PPP3CA protein18344631
D016572CyclosporineCyclosporine results in decreased activity of [PPP3CA protein binds to PPP3R1 protein]19880376
C017160cypermethrin[cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin10898953
D003847DeoxyglucosePPP3CA protein results in decreased susceptibility to Deoxyglucose10679475
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA28628672
C099199dibefurindibefurin results in decreased activity of [PPP3CA protein binds to PPP3R1 protein]19880376
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of PPP3CA mRNA21858171
D004041Dietary FatsDietary Fats results in increased expression of PPP3CA mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of PPP3CA mRNA]19030233
D002117CalcitriolCalcitriol results in increased expression of PPP3CA mRNA16002434
D004112DimercaprolDimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA]16377760
C118739entinostatentinostat results in decreased expression of PPP3CA mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP3CA mRNA"27188386
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased expression of PPP3CA protein]19332462
D000431EthanolEthanol results in increased expression of PPP3CA protein19332462
D000431EthanolEthanol results in decreased expression of PPP3CA mRNA20655511
D011345FenofibrateFenofibrate results in decreased expression of PPP3CA mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in decreased expression of PPP3CA mRNA]21318169
D005419FlavonoidsFlavonoids results in increased expression of PPP3CA mRNA18035473
D005472Fluorouracil[Fluorouracil co-treated with irinotecan] results in increased expression of PPP3CA mRNA16391804
D005472FluorouracilFluorouracil results in increased expression of PPP3CA protein15585135|1680352
D005472FluorouracilPPP3CA protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
D005485FlutamideFlutamide results in increased expression of PPP3CA mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of PPP3CA mRNA23649840
C039281furanfuran results in increased expression of PPP3CA mRNA20562052
D006072GossypolGossypol results in decreased activity of [PPP3CA protein binds to PPP3R1 protein]19880376
D006220Haloperidol[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein16033416
D006220HaloperidolHaloperidol results in decreased expression of PPP3CA mRNA16033416
D006220HaloperidolHaloperidol results in decreased expression of PPP3CA protein16033416
C492448ICG 001ICG 001 results in decreased expression of PPP3CA mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA28628672
C051890irinotecan[Fluorouracil co-treated with irinotecan] results in increased expression of PPP3CA mRNA16391804
C051890irinotecanirinotecan analog results in decreased expression of PPP3CA mRNA18927307
C051890irinotecanPPP3CA protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA28628672
D007657Ketone BodiesKetone Bodies results in increased expression of PPP3CA mRNA16807920
D008694MethamphetamineMethamphetamine results in increased expression of PPP3CA protein15644446
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CA protein]15644446
D008713MethimazoleMethimazole results in decreased expression of PPP3CA mRNA17403546
D008727MethotrexatePPP3CA protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PPP3CA mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PPP3CA mRNA26011545
C523184mocetinostatmocetinostat results in increased expression of PPP3CA mRNA27255383
D009151Mustard GasDimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA]16377760
D009151Mustard GasMustard Gas results in decreased expression of PPP3CA mRNA16377760
D009151Mustard GasMustard Gas affects the expression of PPP3CA mRNA15651846
C027793mustard oilPPP3CA protein affects the reaction [mustard oil inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]]17590514
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PPP3CA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PPP3CA mRNA"25554681
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of PPP3CA mRNA15878706
C025256nonylphenolnonylphenol results in increased expression of PPP3CA mRNA22982499
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PPP3CA mRNA25729387
D010269ParaquatParaquat results in increased expression of PPP3CA mRNA28619522
C095579PD 144795PD 144795 results in decreased activity of [PPP3CA protein binds to PPP3R1 protein]19880376
C494474perchlorateperchlorate results in decreased expression of PPP3CA mRNA17403546
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PPP3CA mRNA20136073
D020913PerindoprilPerindopril results in decreased expression of PPP3CA protein18344631
D010634PhenobarbitalPhenobarbital affects the expression of PPP3CA mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of PPP3CA mRNA19363144
C006253pirinixic acidpirinixic acid results in decreased expression of PPP3CA mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of PPP3CA mRNA]21318169
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of PPP3CA mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of PPP3CA mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of PPP3CA mRNA19363144
D011441PropylthiouracilPropylthiouracil results in decreased expression of PPP3CA mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of PPP3CA mRNA17403546
D011794QuercetinQuercetin results in decreased activity of [PPP3CA protein binds to PPP3R1 protein]19880376
D011794QuercetinQuercetin results in decreased expression of PPP3CA mRNA21632981
D011794QuercetinPPP3R1 protein promotes the reaction [Quercetin results in decreased activity of PPP3CA protein]19880376
D011794QuercetinQuercetin results in decreased activity of PPP3CA protein19880376
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of PPP3CA mRNA]19030233
D018967Risperidone[Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein16033416
D018967RisperidoneRisperidone results in decreased expression of PPP3CA mRNA16033416
D018967RisperidoneRisperidone results in decreased expression of PPP3CA protein16033416
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CA protein]15644446
C017947sodium arsenitesodium arsenite affects the methylation of PPP3CA gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of PPP3CA mRNA27862939
D012999SomanSoman results in decreased expression of PPP3CA mRNA19281266
D019311StaurosporineStaurosporine results in increased cleavage of PPP3CA protein10898953
D019311StaurosporinePPP3CA protein results in decreased susceptibility to Staurosporine10679475
D016559Tacrolimus[Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin10898953
D016559TacrolimusTacrolimus results in decreased activity of PPP3CA protein19553475
D016559TacrolimusTacrolimus results in decreased activity of [PPP3CA protein binds to PPP3R1 protein]19880376
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPP3CA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPP3CA mRNA21215274
D019284Thapsigargin[cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin10898953
D019284Thapsigargin[Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin10898953
D019284ThapsigarginThapsigargin promotes the reaction [PPP3CA protein results in decreased phosphorylation of NFATC1 protein]10898953
D019284ThapsigarginThapsigargin results in increased cleavage of PPP3CA protein10898953
D019284ThapsigarginThapsigargin results in increased expression of PPP3CA mRNA17963750
D024505TocopherolsTocopherols results in increased expression of PPP3CA mRNA17654050
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PPP3CA mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PPP3CA mRNA16140955|2193413
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of PPP3CA mRNA]15363585
D014241TrichloroethyleneTrichloroethylene results in increased expression of PPP3CA mRNA19448997
C057693troglitazonetroglitazone results in decreased expression of PPP3CA mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of PPP3CA mRNA17127020
C004218tylophorinetylophorine analog results in increased expression of PPP3CA mRNA19284764
D014635Valproic AcidValproic Acid affects the expression of PPP3CA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of PPP3CA gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PPP3CA mRNA23179753
C025643vinclozolinvinclozolin affects the expression of PPP3CA mRNA19015723
C088658zoledronic acidzoledronic acid results in increased expression of PPP3CA mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004722protein serine/threonine phosphatase activity-NAS8392375  
GO:0005509calcium ion binding-NAS8392375  
GO:0005515protein binding-IPI8524402  11114196  11842093  12218175  12357034  12577067  
12809556  17474147  18218901  18838687  19896943  21900206  
22688515  24418105  25416956  26248042  27974827  
GO:0005516calmodulin binding-IBA21873635  
GO:0005516calmodulin binding-IDA11005320  18384083  19404396  
GO:0005516calmodulin binding-NAS8392375  
GO:0008144drug binding-IDA11005320  
GO:0016018cyclosporin A binding-IDA12218175  12357034  
GO:0019899enzyme binding-IDA11005320  
GO:0033192calmodulin-dependent protein phosphatase activity-IBA21873635  
GO:0033192calmodulin-dependent protein phosphatase activity-IDA18815128  19154138  23468591  
GO:0033192calmodulin-dependent protein phosphatase activity-TAS2556704  
GO:0046982protein heterodimerization activity-IEA-  
GO:0046983protein dimerization activity-IPI11005320  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-IEA-  
GO:0001975response to amphetamine-IEA-  
GO:0006470protein dephosphorylation-IDA18815128  19154138  
GO:0006470protein dephosphorylation-IMP23468591  
GO:0006470protein dephosphorylation-NAS8392375  
GO:0006606protein import into nucleus-IEA-  
GO:0006816calcium ion transport-IEA-  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0014883transition between fast and slow fiber-IEA-  
GO:0014898cardiac muscle hypertrophy in response to stress-IEA-  
GO:0016311dephosphorylation-TAS2556704  
GO:0033173calcineurin-NFAT signaling cascade-IBA21873635  
GO:0033173calcineurin-NFAT signaling cascade-IDA19154138  22688515  
GO:0033173calcineurin-NFAT signaling cascade-IMP22343722  23468591  26248042  
GO:0033555multicellular organismal response to stress-IEA-  
GO:0035562negative regulation of chromatin binding-IEA-  
GO:0035690cellular response to drug-IDA11005320  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0042110T cell activation-TAS11005320  
GO:0045807positive regulation of endocytosis-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA22688515  
GO:0046676negative regulation of insulin secretion-IEA-  
GO:0048741skeletal muscle fiber development-IEA-  
GO:0050774negative regulation of dendrite morphogenesis-IEA-  
GO:0050804modulation of chemical synaptic transmission-IEA-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IEA-  
GO:0051592response to calcium ion-IDA18815128  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0070886positive regulation of calcineurin-NFAT signaling cascade-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0097720calcineurin-mediated signaling-IBA21873635  
GO:1903244positive regulation of cardiac muscle hypertrophy in response to stress-IEA-  
GO:1903799negative regulation of production of miRNAs involved in gene silencing by miRNA-IEA-  
GO:1905205positive regulation of connective tissue replacement-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA19154138  22343722  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005955calcineurin complex-IBA21873635  
GO:0005955calcineurin complex-IDA12218175  12357034  22343722  22688515  23468591  27974827  
GO:0005955calcineurin complex-NAS8392375  
GO:0009898cytoplasmic side of plasma membranecolocalizes_withIDA22343722  
GO:0030018Z disc-IEA-  
GO:0042383sarcolemma-IEA-  
GO:0043197dendritic spine-IDA22343722  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04114Oocyte meiosis
hsa04210Apoptosis
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04720Long-term potentiation
hsa05010Alzheimer's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingIEA
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)IEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-180024DARPP-32 eventsIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-2025928Calcineurin activates NFATTAS
R-HSA-2025928Calcineurin activates NFATIEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-5607763CLEC7A (Dectin-1) induces NFAT activationTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26997180DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample. (2016 Mar)Fudalej SJ Stud Alcohol Drugs