Gene: GIMAP4

55303
IAN-1|IAN1|IMAP4|MSTP062
GTPase, IMAP family member 4
protein-coding
7q36.1
Ensembl:ENSG00000133574 MIM:608087 Vega:OTTHUMG00000157475 UniprotKB:Q9NUV9
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.041e-1 (AD)  7.166e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9640279chr7:150571010 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GIMAP70.901
GIMAP80.897
SP1000.886
GIMAP10.883
GIMAP60.879
CARD60.872
FLI10.872
TGFBR20.865
TRIM380.854
ARPC1B0.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.428
CPLX3-0.409
MARCH4-0.403
ZSCAN1-0.392
KCNIP3-0.392
HAS1-0.39
KREMEN2-0.39
CHRNA4-0.389
KCNK4-0.388
HES5-0.386

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0005974662-(4-(3-(1-(4-(2-aminopyrimidin-5-yl)phenyl)-1-cyclopropylethyl)-(1,2,4)oxadiazol-5-yl)pyrazol-1-yl)-N,N-dimethylacetamide"2-(4-(3-(1-(4-(2-aminopyrimidin-5-yl)phenyl)-1-cyclopropylethyl)-(1,2,4)oxadiazol-5-yl)pyrazol-1-yl)-N,N-dimethylacetamide results in decreased expression of GIMAP4 mRNA"28167222
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of GIMAP4 protein26194647
D000082AcetaminophenAcetaminophen results in decreased expression of GIMAP4 mRNA21420995
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of GIMAP4 mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GIMAP4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GIMAP4 mRNA24449571
D001280AtrazineAtrazine results in increased expression of GIMAP4 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GIMAP4 mRNA19770486|2171566
C006780bisphenol Abisphenol A results in decreased expression of GIMAP4 mRNA25181051
C006780bisphenol Abisphenol A results in decreased methylation of GIMAP4 gene28505145
D002737ChloropreneChloroprene results in decreased expression of GIMAP4 mRNA23125180
D003520CyclophosphamideCyclophosphamide results in decreased expression of GIMAP4 mRNA27466211
D004041Dietary FatsDietary Fats results in increased expression of GIMAP4 mRNA18042831
C024565ethylene dichlorideethylene dichloride results in decreased expression of GIMAP4 mRNA28189721
C039281furanfuran results in increased expression of GIMAP4 mRNA27387713
D005839GentamicinsGentamicins results in increased expression of GIMAP4 mRNA22061828
C010974glyphosateglyphosate results in decreased expression of GIMAP4 mRNA25636363
D017313FenretinideFenretinide results in increased expression of GIMAP4 mRNA28973697
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GIMAP4 mRNA27339419
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GIMAP4 mRNA"25554681
D009532NickelNickel results in decreased expression of GIMAP4 mRNA23195993
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GIMAP4 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of GIMAP4 mRNA25729387
D010126OzoneOzone results in decreased expression of GIMAP4 mRNA17095637
D000073878Palm OilPalm Oil results in increased expression of GIMAP4 mRNA18042831
C006253pirinixic acidpirinixic acid results in decreased expression of GIMAP4 mRNA17426115
D011137PolystyrenesPolystyrenes analog results in decreased expression of GIMAP4 mRNA25102311
D053260SootSoot results in decreased expression of GIMAP4 mRNA26551751
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GIMAP4 mRNA22363418
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GIMAP4 mRNA25729387
D019772TopotecanTopotecan results in increased expression of GIMAP4 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of GIMAP4 gene27618143
D014635Valproic AcidValproic Acid results in decreased methylation of GIMAP4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of GIMAP4 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GIMAP4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005525GTP binding-IBA21873635  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA23454188  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal