Gene: PPP3CB

5532
CALNA2|CALNB|CNA2|PP2Bbeta
protein phosphatase 3 catalytic subunit beta
protein-coding
10q22.2
Ensembl:ENSG00000107758 MIM:114106 Vega:OTTHUMG00000018472 UniprotKB:P16298
NC_000010.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.333e-1 (AD)  3.386e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11000671chr10:73480219 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP2K40.985
ATP6V1A0.983
TRIM370.983
ATP6V1C10.981
MAPK90.98
NSF0.979
MOAP10.979
PCMT10.978
SNAP910.978
GLS0.976

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.526
OR4F5-0.514
RNF135-0.495
MYL3-0.486
REST-0.484
HEY2-0.48
MAGEA12-0.479
CHST14-0.477
OR4F29-0.475
CNN2-0.465

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PPP3CB mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PPP3CB mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of PPP3CB mRNA25704631
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PPP3CB gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PPP3CB mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of PPP3CB mRNA20138156
D001280AtrazineAtrazine results in increased expression of PPP3CB mRNA22378314
D001554BenzeneBenzene results in decreased expression of PPP3CB mRNA16188087
C044887beta-methylcholinebeta-methylcholine affects the expression of PPP3CB mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of PPP3CB mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PPP3CB mRNA25181051
D002104CadmiumCadmium results in decreased expression of PPP3CB mRNA23358151
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PPP3CB promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PPP3CB mRNA23650126
C018021cobaltous chloridecobaltous chloride results in decreased expression of PPP3CB mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in decreased expression of PPP3CB mRNA19549813
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPP3CB mRNA]11007951
D016572CyclosporineCyclosporine results in decreased expression of PPP3CB mRNA25562108
D013759DronabinolDronabinol results in increased expression of PPP3CB mRNA17578508
C007262deoxynivalenoldeoxynivalenol results in increased expression of PPP3CB mRNA15371230|1568116
C007262deoxynivalenol"Fatty Acids, Omega-3 promotes the reaction [deoxynivalenol results in increased expression of PPP3CB mRNA]"15681167
D003907DexamethasoneDexamethasone results in decreased expression of PPP3CB mRNA12782123
D002945CisplatinCisplatin results in decreased expression of PPP3CB protein16803524
D004041Dietary FatsDietary Fats results in increased expression of PPP3CB mRNA19030233
D002117CalcitriolCalcitriol results in increased expression of PPP3CB mRNA16002434
D000431EthanolEthanol results in decreased expression of PPP3CB mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of PPP3CB mRNA]"20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PPP3CB mRNA20227414
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPP3CB mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PPP3CB mRNA23649840
D018120FinasterideFinasteride results in increased expression of PPP3CB mRNA24136188
D005419FlavonoidsFlavonoids results in increased expression of PPP3CB mRNA18035473
D005485FlutamideFlutamide results in decreased expression of PPP3CB mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of PPP3CB mRNA23649840
D005839GentamicinsGentamicins results in increased expression of PPP3CB mRNA22061828
C010974glyphosateglyphosate results in increased expression of PPP3CB mRNA17984146
C492448ICG 001ICG 001 results in decreased expression of PPP3CB mRNA26191083
C051890irinotecanirinotecan metabolite results in decreased expression of PPP3CB mRNA15956246
C051890irinotecanirinotecan results in decreased expression of PPP3CB mRNA15956246
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PPP3CB mRNA23430699
D008628MercuryMercury results in decreased expression of PPP3CB mRNA22008530
D008694MethamphetamineMethamphetamine results in increased expression of PPP3CB protein15644446
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CB protein]15644446
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PPP3CB mRNA23649840
C051752nefazodonenefazodone results in increased expression of PPP3CB mRNA24136188
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of PPP3CB mRNA]"20655511
C025589ochratoxin Aochratoxin A results in decreased expression of PPP3CB mRNA19287073|2212462
C025589ochratoxin Aochratoxin A results in decreased expression of PPP3CB mRNA22124623
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 promotes the reaction [deoxynivalenol results in increased expression of PPP3CB mRNA]"15681167
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PPP3CB mRNA25729387
D052638Particulate MatterParticulate Matter results in decreased expression of PPP3CB mRNA17987463
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of PPP3CB mRNA17097637
D010656PhenylephrinePhenylephrine results in increased expression of PPP3CB mRNA16024800
D010656PhenylephrineCABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]10655507
D010656PhenylephrinePhenylephrine results in increased activity of PPP3CB protein10655507
D010656PhenylephrinePhenylephrine results in increased expression of PPP3CB mRNA10655507
D010656PhenylephrinePhenylephrine results in increased expression of PPP3CB protein10655507
D010795Phthalic AcidsPhthalic Acids results in increased expression of PPP3CB mRNA21061450
D059808PolyphenolsPolyphenols results in increased expression of PPP3CB mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in increased expression of PPP3CB mRNA11678601
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CB protein]15644446
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPP3CB mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPP3CB mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPP3CB mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPP3CB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPP3CB mRNA21215274
D019284ThapsigarginThapsigargin results in decreased expression of PPP3CB protein24648495
D013806TheophyllineTheophylline results in decreased expression of PPP3CB mRNA16083514
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PPP3CB mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of PPP3CB mRNA"19682533
D014415TunicamycinTunicamycin results in increased expression of PPP3CB mRNA20138156
D014415TunicamycinTunicamycin results in decreased expression of PPP3CB mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of PPP3CB mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of PPP3CB gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PPP3CB mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of PPP3CB mRNA17987463
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PPP3CB gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004722protein serine/threonine phosphatase activity-NAS8392375  
GO:0005509calcium ion binding-IDA8524402  
GO:0005515protein binding-IPI21903422  22688515  26794871  
GO:0005516calmodulin binding-IBA21873635  
GO:0005516calmodulin binding-IDA2556704  11005320  26794871  
GO:0005516calmodulin binding-NAS8524402  
GO:0008144drug binding-IDA11005320  
GO:0019899enzyme binding-IDA11005320  
GO:0030346protein phosphatase 2B binding-IDA2556704  
GO:0033192calmodulin-dependent protein phosphatase activity-IBA21873635  
GO:0033192calmodulin-dependent protein phosphatase activity-IDA19154138  26794871  
GO:0033192calmodulin-dependent protein phosphatase activity-ISS-  
GO:0033192calmodulin-dependent protein phosphatase activity-TAS2556704  
GO:0046983protein dimerization activity-IPI11005320  
GO ID GO Term Qualifier Evidence PubMed
GO:0001915negative regulation of T cell mediated cytotoxicity-IEA-  
GO:0001946lymphangiogenesis-IEA-  
GO:0006468protein phosphorylation-ISS-  
GO:0006470protein dephosphorylation-IDA19154138  26794871  
GO:0006470protein dephosphorylation-ISS-  
GO:0007165signal transduction-NAS8978785  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0007507heart development-IEA-  
GO:0007612learning-TAS21531385  
GO:0007613memory-TAS21531385  
GO:0016311dephosphorylation-TAS2556704  
GO:0017156calcium ion regulated exocytosis-ISS-  
GO:0030217T cell differentiation-IEA-  
GO:0031987locomotion involved in locomotory behavior-IEA-  
GO:0033173calcineurin-NFAT signaling cascade-IDA19154138  22688515  
GO:0034097response to cytokine-IEA-  
GO:0035176social behavior-IEP21531385  
GO:0035690cellular response to drug-IDA11005320  
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus-ISS-  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0042098T cell proliferation-NAS8978785  
GO:0042110T cell activation-TAS11005320  
GO:0043029T cell homeostasis-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-NAS8978785  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA22688515  
GO:0048167regulation of synaptic plasticity-TAS21531385  
GO:0048675axon extension-TAS21531385  
GO:0050796regulation of insulin secretion-ISS-  
GO:0097720calcineurin-mediated signaling-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA19154138  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-ISS-  
GO:0005955calcineurin complex-IBA21873635  
GO:0005955calcineurin complex-IDA8524402  22688515  26794871  
GO:0030018Z disc-IEA-  
GO:0030315T-tubule-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04114Oocyte meiosis
hsa04210Apoptosis
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04720Long-term potentiation
hsa05010Alzheimer's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingIEA
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)IEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-180024DARPP-32 eventsIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-2025928Calcineurin activates NFATTAS
R-HSA-2025928Calcineurin activates NFATIEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5607763CLEC7A (Dectin-1) induces NFAT activationTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-9010642ROBO receptors bind AKAP5IEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal