Gene: AGPAT5

55326
1AGPAT5|LPAATE
1-acylglycerol-3-phosphate O-acyltransferase 5
protein-coding
8p23.1
Ensembl:ENSG00000155189 MIM:614796 Vega:OTTHUMG00000163656 UniprotKB:Q9NUQ2
NC_000008.11
SNP Mapped
3   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.471e-1 (AD)  8.960e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1046449chr8:6758233 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs2980700chr8:6755315 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2936512chr8:6741484 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZMYND110.864
NUCKS10.855
CASC40.854
FUBP30.853
SEC630.852
SMAD20.851
MRPS140.843
EXOC50.843
SUCO0.843
GPM6B0.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.696
OR4F5-0.687
EPPIN-0.253
MMP23B-0.242
RAX2-0.205
CELSR1-0.179
SLC7A9-0.176
C17orf112-0.176
ANP32C-0.173
RNF223-0.159

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AGPAT5 mRNA"19114083
D000082AcetaminophenAcetaminophen affects the expression of AGPAT5 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of AGPAT5 mRNA25704631
D000082AcetaminophenAcetaminophen results in increased expression of AGPAT5 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of AGPAT5 mRNA28959563
D000638AmiodaroneAmiodarone affects the expression of AGPAT5 mRNA25064622
C006632arsenic trioxidearsenic trioxide results in decreased expression of AGPAT5 mRNA26705709
D001280AtrazineAtrazine results in increased expression of AGPAT5 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AGPAT5 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of AGPAT5 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AGPAT5 mRNA"19150397
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of AGPAT5 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of AGPAT5 mRNA20678512
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of AGPAT5 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of AGPAT5 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AGPAT5 mRNA20883709
D002746ChlorpromazineChlorpromazine affects the expression of AGPAT5 mRNA25064622
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of AGPAT5 mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of AGPAT5 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of AGPAT5 mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of AGPAT5 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AGPAT5 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AGPAT5 mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of AGPAT5 mRNA28302478
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of AGPAT5 mRNA"27840820
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AGPAT5 mRNA25064622
D005557FormaldehydeFormaldehyde results in decreased expression of AGPAT5 mRNA20655997
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGPAT5 mRNA25613284
D007854LeadLead affects the splicing of AGPAT5 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of AGPAT5 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of AGPAT5 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AGPAT5 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of AGPAT5 mRNA29191790
D008942MitoxantroneAGPAT5 protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AGPAT5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AGPAT5 mRNA"25554681
D009532NickelNickel results in increased expression of AGPAT5 mRNA25583101
C464660obeticholic acidobeticholic acid results in decreased expression of AGPAT5 mRNA27939613
D010269ParaquatParaquat affects the expression of AGPAT5 mRNA25064622
C045950propiconazolepropiconazole results in increased expression of AGPAT5 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of AGPAT5 mRNA24780913
D012402RotenoneRotenone results in decreased expression of AGPAT5 mRNA19013527
D012715Sesame OilSesame Oil results in increased expression of AGPAT5 mRNA29191790
C017947sodium arsenitesodium arsenite results in increased expression of AGPAT5 mRNA20883709
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AGPAT5 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGPAT5 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AGPAT5 promoter]19654925
D013752TetracyclineTetracycline affects the expression of AGPAT5 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGPAT5 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of AGPAT5 mRNA25064622
D013853ThioacetamideThioacetamide results in increased expression of AGPAT5 mRNA23411599
D014520UrethaneUrethane results in decreased expression of AGPAT5 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of AGPAT5 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of AGPAT5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AGPAT5 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of AGPAT5 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of AGPAT5 mRNA28001369|2915479
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AGPAT5 gene25560391
C025643vinclozolinvinclozolin results in increased expression of AGPAT5 mRNA23869203
C088658zoledronic acidzoledronic acid results in increased expression of AGPAT5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-IBA21873635  
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-NAS15367102  
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0016746transferase activity, transferring acyl groups-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO:0006639acylglycerol metabolic process-IEA-  
GO:0006644phospholipid metabolic process-IBA21873635  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0008654phospholipid biosynthetic process-NAS15367102  
GO:0016024CDP-diacylglycerol biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IEA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0012505endomembrane system-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal