Gene: LAPTM4B

55353
LAPTM4beta|LC27
lysosomal protein transmembrane 4 beta
protein-coding
8q22.1
Ensembl:ENSG00000104341 MIM:613296 Vega:OTTHUMG00000164740 UniprotKB:Q86VI4
NC_000008.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.175e-1 (AD)  4.984e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20541656chr8:98787334LAPTM4BPromoter4.264e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNRNPA00.898
CKAP40.897
CHCHD30.894
VDAC20.893
PSME30.889
RAB1A0.883
RDH110.883
MMADHC0.882
CDC420.873
KHDRBS10.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.715
OR4F29-0.66
TNFRSF13B-0.268
CTNNA3-0.23
TRPV5-0.219
PPBP-0.218
VNN3-0.216
P2RY14-0.199
MTRNR2L6-0.193
MTRNR2L9-0.18

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LAPTM4B mRNA"15215175
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LAPTM4B mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LAPTM4B mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of LAPTM4B mRNA29067470
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of LAPTM4B mRNA28522335
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LAPTM4B mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of LAPTM4B mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of LAPTM4B mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of LAPTM4B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LAPTM4B gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LAPTM4B mRNA18560533
C100187chloropicrinchloropicrin affects the expression of LAPTM4B mRNA26352163
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of LAPTM4B mRNA20971185
D003300CopperCopper results in increased expression of LAPTM4B mRNA17205981
D019327Copper SulfateCopper Sulfate results in decreased expression of LAPTM4B mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of LAPTM4B mRNA19789285
D016572CyclosporineCyclosporine results in decreased expression of LAPTM4B mRNA20106945|2798913
C014347decitabinedecitabine affects the expression of LAPTM4B mRNA23300844
D002945CisplatinCisplatin affects the expression of LAPTM4B mRNA23300844
D002945CisplatinCisplatin results in increased expression of LAPTM4B mRNA27392435
D002945CisplatinLAPTM4B protein affects the susceptibility to Cisplatin16217747
D004237DiuronDiuron results in decreased expression of LAPTM4B mRNA21551480
D017313FenretinideFenretinide results in decreased expression of LAPTM4B mRNA28973697
C492448ICG 001ICG 001 results in increased expression of LAPTM4B mRNA26191083
D007213IndomethacinIndomethacin results in decreased expression of LAPTM4B mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LAPTM4B mRNA25613284
D007649KetamineKetamine results in increased expression of LAPTM4B mRNA20080153
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LAPTM4B mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LAPTM4B mRNA"26251327
C028007nickel monoxidenickel monoxide results in increased expression of LAPTM4B mRNA19167457
C012655nimesulidenimesulide results in decreased expression of LAPTM4B mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of LAPTM4B mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LAPTM4B mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of LAPTM4B mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of LAPTM4B mRNA19159669
C006253pirinixic acidpirinixic acid results in decreased expression of LAPTM4B mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of LAPTM4B mRNA23811191
D011441PropylthiouracilPropylthiouracil results in decreased expression of LAPTM4B mRNA24780913
D012402RotenoneRotenone results in increased expression of LAPTM4B mRNA23186747
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of LAPTM4B mRNA"26680231
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of LAPTM4B mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LAPTM4B mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LAPTM4B mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LAPTM4B mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of LAPTM4B mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of LAPTM4B mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LAPTM4B mRNA25729387
D014212TretinoinTretinoin results in decreased expression of LAPTM4B mRNA23724009
D014212TretinoinTretinoin results in increased expression of LAPTM4B mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of LAPTM4B mRNA19042947
C080163trovafloxacintrovafloxacin results in decreased expression of LAPTM4B mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of LAPTM4B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LAPTM4B mRNA23179753|2915479

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20711237  21224396  22096579  25416956  25588945  25594178  
25998567  26126825  28479384  
GO:0019900kinase binding-IPI25588945  
GO:0031625ubiquitin protein ligase binding-IPI25588945  
GO:0097001ceramide binding-IDA26280656  
GO:1902936phosphatidylinositol bisphosphate binding-IDA25588945  
GO ID GO Term Qualifier Evidence PubMed
GO:0007032endosome organization-IMP21224396  
GO:0032509endosome transport via multivesicular body sorting pathway-IDA25588945  
GO:0032911negative regulation of transforming growth factor beta1 production-IDA26126825  
GO:0097213regulation of lysosomal membrane permeability-IMP26280656  
GO:1905166negative regulation of lysosomal protein catabolic process-IMP25588945  
GO:1905671regulation of lysosome organization-IMP26280656  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IDA25588945  
GO:0005765lysosomal membrane-IDA21224396  22096579  
GO:0005768endosome-IDA25588945  
GO:0005769early endosome-IDA25588945  
GO:0005886plasma membrane-IDA22096579  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0031902late endosome membrane-IDA21224396  22096579  25588945  
GO:0032585multivesicular body membrane-IDA25588945  26280656  
GO:0042995cell projection-IDA22096579  
GO:0097487multivesicular body, internal vesicle-IDA26280656  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28618967Association of lysosomal protein transmembrane 4 beta gene polymorphism with pancreatic carcinoma susceptibility in the Chinese population. (2017 Jun)Wang BTumour Biol
21656743Correlation of LAPTM4B polymorphisms with cervical carcinoma. (2011 Jun 15)Meng FCancer