Gene: TBC1D2

55357
PARIS-1|PARIS1|TBC1D2A
TBC1 domain family member 2
protein-coding
9q22.33
Ensembl:ENSG00000095383 MIM:609871 Vega:OTTHUMG00000020343 UniprotKB:Q9BYX2
NC_000009.12
SNP Mapped
1   ANCO-SNPs
ND
0   
1.648e-3 (AD)  3.861e-1 (ND)   (Frontal_Cortex)
2.268e-2 (AD)  8.373e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16914086chr9:98226195 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TJAP10.882
TMEM63A0.856
CD220.827
CDK180.825
NADSYN10.823
CGN0.816
SLC12A90.812
PLEKHG30.809
MYO9B0.808
SHROOM10.807

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.354
OR4F29-0.332
NDNF-0.289
NPBWR1-0.276
CHRNA6-0.27
OR4F16-0.261
FAM216B-0.26
CALB2-0.259
PAX2-0.254
SLC6A2-0.251

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TBC1D2 mRNA"25614096
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TBC1D2 mRNA"28973690
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TBC1D2 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D2 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of TBC1D2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TBC1D2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TBC1D2 mRNA19770486
C068073Am 580Am 580 results in increased expression of TBC1D2 mRNA16982809
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TBC1D2 mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of TBC1D2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of TBC1D2 gene25435355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBC1D2 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of TBC1D2 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of TBC1D2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of TBC1D2 mRNA20147733
C018475butyraldehydebutyraldehyde results in increased expression of TBC1D2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of TBC1D2 promoter22457795
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBC1D2 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of TBC1D2 mRNA19549813
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of TBC1D2 mRNA"25908611
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TBC1D2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TBC1D2 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of TBC1D2 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of TBC1D2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TBC1D2 mRNA21592394
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TBC1D2 mRNA22079256
C000499ferric oxideferric oxide analog results in decreased expression of TBC1D2 mRNA24525745
C000499ferric oxideferric oxide analog results in increased expression of TBC1D2 mRNA25086211
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBC1D2 gene20938992
C039281furanfuran results in increased expression of TBC1D2 mRNA26194646
D007052IbuprofenIbuprofen results in increased expression of TBC1D2 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TBC1D2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TBC1D2 mRNA23430699
C045463leflunomideleflunomide results in decreased expression of TBC1D2 mRNA28988120
C045463leflunomideleflunomide results in increased expression of TBC1D2 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBC1D2 gene20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TBC1D2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TBC1D2 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of TBC1D2 mRNA24236059
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TBC1D2 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TBC1D2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TBC1D2 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of TBC1D2 mRNA18037150
C005556propionaldehydepropionaldehyde results in increased expression of TBC1D2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of TBC1D2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TBC1D2 mRNA27029645
C059514resveratrolresveratrol results in increased expression of TBC1D2 mRNA25888808
C089730rosiglitazonerosiglitazone results in increased expression of TBC1D2 mRNA16982809
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TBC1D2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TBC1D2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBC1D2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBC1D2 mRNA21570461|2637764
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TBC1D2 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TBC1D2 mRNA20133372
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TBC1D2 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TBC1D2 mRNA23179753|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005096GTPase activator activity-IDA20116244  
GO:0005515protein binding-IPI22354992  
GO:0017137Rab GTPase binding-IBA21873635  
GO:0045296cadherin binding-IPI20116244  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0043547positive regulation of GTPase activity-IDA20116244  
GO:0090630activation of GTPase activity-IBA21873635  
GO:1902017regulation of cilium assemblyNOTIMP17646400  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005829cytosol-IDA-  
GO:0030054cell junction-IDA20116244  
GO:0031410cytoplasmic vesicle-IDA20116244  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8854214TBC/RABGAPsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal