Gene: PPY

5539
PNP|PP
pancreatic polypeptide
protein-coding
17q21.31
Ensembl:ENSG00000108849 MIM:167780 Vega:OTTHUMG00000181800 UniprotKB:P01298
NC_000017.11
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.211e-1 (AD)  2.338e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MMP10.534
LGALS40.398
GOLGA8G0.375
KRTAP5-20.368
REG40.366
CXorf660.36
KRTAP22-20.347
CGB80.344
TCF210.338
VN1R30.33

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNRNPCL1-0.216
CLUL1-0.156
SMN2-0.15
GLOD5-0.149
PDE6C-0.148
MYOZ2-0.145
KCNRG-0.143
SYCE1-0.141
TPSB2-0.14
CSN1S1-0.139

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PPY mRNA"19114083
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PPY mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PPY mRNA]17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PPY mRNA16483693
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PPY mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of PPY promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of PPY mRNA25181051
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PPY mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PPY mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of PPY mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PPY mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PPY mRNA27392435
D002945CisplatinCisplatin results in increased expression of PPY mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PPY mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPY mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PPY mRNA23649840
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PPY mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PPY mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PPY mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PPY mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PPY mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PPY mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PPY mRNA"25554681
C055122orlistatorlistat inhibits the reaction [Triglycerides results in increased secretion of PPY protein]15998659
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPY mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPY mRNA21215274
C009495titanium dioxidetitanium dioxide results in increased expression of PPY mRNA27760801
D014280Triglyceridesorlistat inhibits the reaction [Triglycerides results in increased secretion of PPY protein]15998659
D014280TriglyceridesTriglycerides results in increased secretion of PPY protein15998659
D014635Valproic AcidValproic Acid results in increased methylation of PPY gene29154799
D014801Vitamin A[Vitamin A co-treated with INHBA protein] results in increased expression of PPY mRNA17244017

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0001664G-protein coupled receptor binding-IPI7493937  7592911  
GO:0005179hormone activity-IBA21873635  
GO:0005179hormone activity-TAS2997153  
GO:0005184neuropeptide hormone activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007267cell-cell signaling-IBA21873635  
GO:0007631feeding behavior-IBA21873635  
GO:0009306protein secretion-TAS2997153  
GO:0010469regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14643449Association between glutathione S-transferase M1 and T1 polymorphisms and increased risk for bladder cancer in Korean smokers. (2003 Dec 30)Jong Jeong HCancer Lett