Gene: DNAJA4

55466
MST104|MSTP104|PRO1472
DnaJ heat shock protein family (Hsp40) member A4
protein-coding
15q25.1
Ensembl:ENSG00000140403 Vega:OTTHUMG00000143733 UniprotKB:Q8WW22
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.478e-1 (AD)  5.105e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSPH10.927
FKBP40.897
DNAJA10.884
FBXL140.882
TCP10.871
HSP90AA10.862
CACYBP0.854
HSPA40.85
DNAJB60.843
ZFAND2A0.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.515
OR4F29-0.502
CEACAM4-0.322
CC2D2B-0.319
P2RY14-0.318
CXCR2-0.317
VNN3-0.315
KLRB1-0.314
KLRF1-0.308
IL18RAP-0.301

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of DNAJA4 mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DNAJA4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DNAJA4 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of DNAJA4 mRNA"18648102
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of DNAJA4 mRNA"19561079
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to DNAJA4 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to DNAJA4 protein]26598702
D000082AcetaminophenAcetaminophen results in increased expression of DNAJA4 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of DNAJA4 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of DNAJA4 mRNA17202762
D020106AcrylamideAcrylamide results in increased expression of DNAJA4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DNAJA4 mRNA19770486
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to DNAJA4 protein]26598702
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of DNAJA4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DNAJA4 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DNAJA4 mRNA19770486
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of DNAJA4 mRNA20404318
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DNAJA4 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of DNAJA4 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DNAJA4 mRNA28628672
D002104CadmiumCadmium results in increased expression of DNAJA4 mRNA21120746|2336940
D019256Cadmium ChlorideCadmium Chloride affects the expression of DNAJA4 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DNAJA4 mRNA19010381
C100187chloropicrinchloropicrin results in increased expression of DNAJA4 mRNA26352163
D002737ChloropreneChloroprene results in increased expression of DNAJA4 mRNA23125180
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of DNAJA4 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of DNAJA4 mRNA20971185
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of DNAJA4 mRNA25167922
C030973cupric oxidecupric oxide results in increased expression of DNAJA4 mRNA22077320
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DNAJA4 mRNA23914054
C014347decitabinedecitabine results in increased expression of DNAJA4 mRNA21856257
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DNAJA4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DNAJA4 mRNA28628672
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of DNAJA4 mRNA27638505
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of DNAJA4 mRNA24690739
D004237DiuronDiuron results in decreased expression of DNAJA4 mRNA21551480
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of DNAJA4 mRNA"23811387
D005557FormaldehydeFormaldehyde results in increased expression of DNAJA4 mRNA20655997
D017313FenretinideFenretinide results in increased expression of DNAJA4 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of DNAJA4 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DNAJA4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DNAJA4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DNAJA4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DNAJA4 mRNA28628672
D008694MethamphetamineMethamphetamine results in increased expression of DNAJA4 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DNAJA4 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DNAJA4 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DNAJA4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DNAJA4 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of DNAJA4 mRNA23811387
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of DNAJA4 mRNA20551477
C029938nickel sulfatenickel sulfate results in decreased expression of DNAJA4 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of DNAJA4 mRNA20971185
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of DNAJA4 mRNA25167922
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DNAJA4 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of DNAJA4 mRNA25729387
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJA4 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of DNAJA4 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of DNAJA4 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJA4 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJA4 mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of DNAJA4 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of DNAJA4 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJA4 mRNA]17655762
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of DNAJA4 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of DNAJA4 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DNAJA4 mRNA26794494
D010634PhenobarbitalPhenobarbital affects the expression of DNAJA4 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of DNAJA4 mRNA23811191
D010938Plant OilsPlant Oils results in increased expression of DNAJA4 mRNA23370395
D011192Potassium DichromatePotassium Dichromate results in decreased expression of DNAJA4 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of DNAJA4 mRNA23018184
C045950propiconazolepropiconazole results in increased expression of DNAJA4 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of DNAJA4 mRNA24780913
C031280pyrazolepyrazole results in increased expression of DNAJA4 mRNA17945193
D012715Sesame OilSesame Oil results in increased expression of DNAJA4 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DNAJA4 mRNA23806026|2589566
D012834SilverSilver results in increased expression of DNAJA4 mRNA28959546
D012906SmokeSmoke results in increased expression of DNAJA4 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of DNAJA4 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of DNAJA4 mRNA16014739
D012969Sodium FluorideSodium Fluoride results in increased expression of DNAJA4 protein28918527
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of DNAJA4 mRNA25172293
C009495titanium dioxidetitanium dioxide results in decreased expression of DNAJA4 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DNAJA4 mRNA22363418|2806579
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DNAJA4 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of DNAJA4 mRNA25729387
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of DNAJA4 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of DNAJA4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DNAJA4 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of DNAJA4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of DNAJA4 mRNA21318169
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of DNAJA4 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of DNAJA4 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJA4 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DNAJA4 gene25560391
C025643vinclozolinvinclozolin affects the expression of DNAJA4 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of DNAJA4 mRNA26682919
D015032ZincZinc deficiency results in decreased expression of DNAJA4 mRNA22171008
D015034Zinc OxideZinc Oxide results in increased expression of DNAJA4 protein21769377

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25036637  
GO:0005524ATP binding-IEA-  
GO:0031072heat shock protein binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0051082unfolded protein binding-IDA21231916  
GO:0051087chaperone binding-IPI21231916  
GO ID GO Term Qualifier Evidence PubMed
GO:0009408response to heat-IEA-  
GO:0042026protein refolding-IDA21231916  
GO:0090084negative regulation of inclusion body assembly-IDA21231916  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA21231916  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IDA21231916  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371497HSP90 chaperone cycle for steroid hormone receptors (SHR)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24550170Smoking induces transcription of the heat shock protein system in the joints. (2014 Jul)Ospelt CAnn Rheum Dis